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- W3004694254 abstract "Medication adherence in drug trials is suboptimal, affecting the quality of these studies and adding significant costs. Nonadherence in this setting can lead to null findings, unduly large sample sizes and the need for dose modification after a drug has been approved. Despite these drawbacks, adherence behaviours are not consistently measured, analysed or reported appropriately in trial settings. The ESPACOMP Medication Adherence Reporting Guideline (EMERGE) offers a solution by facilitating a sound protocol design that takes this crucial factor into account. This article summarises key evidence on traditional and newer measurements of adherence, discusses implementation in clinical trial settings and makes recommendations about the analysis and interpretation of adherence data. Given the potential benefits of this approach, the authors call on regulators and the pharmaceutical industry to endorse the EMERGE guideline." @default.
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- W3004694254 date "2020-02-28" @default.
- W3004694254 modified "2023-09-30" @default.
- W3004694254 title "How the EMERGE guideline on medication adherence can improve the quality of clinical trials" @default.
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- W3004694254 doi "https://doi.org/10.1111/bcp.14240" @default.
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