FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004769500> ?p ?o ?g. }

• W3004769500 abstract "Aging, noise, and ototoxic drug-induced hair cell (HC) loss are the major causes of sensorineural hearing loss. Aminoglycoside antibiotics are commonly used in the clinic, but these often have ototoxic side effects due to the accumulation of oxygen free radicals and the subsequent induction of HC apoptosis. Blebbistatin is a myosin II inhibitor that regulates microtubule assembly and myosin-actin interactions, and most research has focused on its ability to modulate cardiac or urinary bladder contractility. By regulating the cytoskeletal structure and reducing the accumulation of reactive oxygen species (ROS), blebbistatin can prevent apoptosis in many different types of cells. However, there are no reports on the effect of blebbistatin in HC apoptosis. In this study, we found that the presence of blebbistatin significantly inhibited neomycin-induced apoptosis in HC-like HEI-OC-1 cells. We also found that blebbistatin treatment significantly increased the mitochondrial membrane potential, decreased ROS accumulation, and inhibited pro-apoptotic gene expression in both HC-like HEI-OC-1 cells and explant-cultured cochlear HCs after neomycin exposure. And meanwhile, blebbistatin can protect the synaptic connections between hair cells and cochlear spiral ganglion neurons. This study showed that blebbistatin could maintain mitochondrial function and reduce the ROS level and thus could maintain the viability of HCs after neomycin exposure and the neural function in inner ear, suggesting that blebbistatin has potential clinic application in protecting against ototoxic drug-induced HC loss." @default.
• W3004769500 created "2020-02-14" @default.
• W3004769500 creator A5001807566 @default.
• W3004769500 creator A5009173399 @default.
• W3004769500 creator A5020088480 @default.
• W3004769500 creator A5024189982 @default.
• W3004769500 creator A5030644488 @default.
• W3004769500 creator A5033811961 @default.
• W3004769500 creator A5035103134 @default.
• W3004769500 creator A5048418763 @default.
• W3004769500 creator A5050421919 @default.
• W3004769500 creator A5053689452 @default.
• W3004769500 creator A5055182003 @default.
• W3004769500 creator A5064859267 @default.
• W3004769500 date "2020-02-05" @default.
• W3004769500 modified "2023-10-18" @default.
• W3004769500 title "Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells" @default.
• W3004769500 cites W1977213615 @default.
• W3004769500 cites W1981410060 @default.
• W3004769500 cites W1985874110 @default.
• W3004769500 cites W2002242519 @default.
• W3004769500 cites W2009582775 @default.
• W3004769500 cites W2012480147 @default.
• W3004769500 cites W2017275974 @default.
• W3004769500 cites W2030029307 @default.
• W3004769500 cites W2040895520 @default.
• W3004769500 cites W2069269881 @default.
• W3004769500 cites W2082396725 @default.
• W3004769500 cites W2087004164 @default.
• W3004769500 cites W2102427988 @default.
• W3004769500 cites W2121966499 @default.
• W3004769500 cites W2127629026 @default.
• W3004769500 cites W2139422271 @default.
• W3004769500 cites W2168154189 @default.
• W3004769500 cites W2170803730 @default.
• W3004769500 cites W2260331015 @default.
• W3004769500 cites W2285686547 @default.
• W3004769500 cites W2293889193 @default.
• W3004769500 cites W2473915971 @default.
• W3004769500 cites W2483712829 @default.
• W3004769500 cites W2509755978 @default.
• W3004769500 cites W2512128868 @default.
• W3004769500 cites W2518818230 @default.
• W3004769500 cites W2579943593 @default.
• W3004769500 cites W2596396352 @default.
• W3004769500 cites W2623078963 @default.
• W3004769500 cites W2760895391 @default.
• W3004769500 cites W2761759723 @default.
• W3004769500 cites W2801310786 @default.
• W3004769500 cites W2802241943 @default.
• W3004769500 cites W2802340168 @default.
• W3004769500 cites W2888614740 @default.
• W3004769500 cites W2889933102 @default.
• W3004769500 cites W2895676937 @default.
• W3004769500 cites W2921718369 @default.
• W3004769500 cites W2923900371 @default.
• W3004769500 cites W2962793500 @default.
• W3004769500 cites W2971400390 @default.
• W3004769500 cites W2972013966 @default.
• W3004769500 cites W4250718850 @default.
• W3004769500 doi "https://doi.org/10.3389/fncel.2019.00590" @default.
• W3004769500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7025583" @default.
• W3004769500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32116554" @default.
• W3004769500 hasPublicationYear "2020" @default.
• W3004769500 type Work @default.
• W3004769500 sameAs 3004769500 @default.
• W3004769500 citedByCount "64" @default.
• W3004769500 countsByYear W30047695002020 @default.
• W3004769500 countsByYear W30047695002021 @default.
• W3004769500 countsByYear W30047695002022 @default.
• W3004769500 countsByYear W30047695002023 @default.
• W3004769500 crossrefType "journal-article" @default.
• W3004769500 hasAuthorship W3004769500A5001807566 @default.
• W3004769500 hasAuthorship W3004769500A5009173399 @default.
• W3004769500 hasAuthorship W3004769500A5020088480 @default.
• W3004769500 hasAuthorship W3004769500A5024189982 @default.
• W3004769500 hasAuthorship W3004769500A5030644488 @default.
• W3004769500 hasAuthorship W3004769500A5033811961 @default.
• W3004769500 hasAuthorship W3004769500A5035103134 @default.
• W3004769500 hasAuthorship W3004769500A5048418763 @default.
• W3004769500 hasAuthorship W3004769500A5050421919 @default.
• W3004769500 hasAuthorship W3004769500A5053689452 @default.
• W3004769500 hasAuthorship W3004769500A5055182003 @default.
• W3004769500 hasAuthorship W3004769500A5064859267 @default.
• W3004769500 hasBestOaLocation W30047695001 @default.
• W3004769500 hasConcept C105702510 @default.
• W3004769500 hasConcept C185592680 @default.
• W3004769500 hasConcept C190283241 @default.
• W3004769500 hasConcept C2776694085 @default.
• W3004769500 hasConcept C2778239845 @default.
• W3004769500 hasConcept C2778500370 @default.
• W3004769500 hasConcept C2778534666 @default.
• W3004769500 hasConcept C2778585322 @default.
• W3004769500 hasConcept C2779152698 @default.
• W3004769500 hasConcept C2779841869 @default.
• W3004769500 hasConcept C48349386 @default.
• W3004769500 hasConcept C501593827 @default.
• W3004769500 hasConcept C54355233 @default.
• W3004769500 hasConcept C55493867 @default.
• W3004769500 hasConcept C6997183 @default.

• next