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- W3004778957 abstract "The membranous lipid-protein complex of pulmonary surfactant (PS) coats the alveolar air-liquid interface and is essential to ensure operational breathing. PS forms a multilamellar surface-active interfacial film with high mechanical stability to withstand breathing dynamics. Typically, the structure of PS membranes has been studied using lipid models or biological extracts from animal lungs. As a consequence, these preparations all differ in their composition and in their observed structure, which may differ to that actually adopted by surfactant complexes as freshly assembled and secreted by the respiratory epithelium. In this context, a surface-active material obtained from human amniotic fluid has been proposed as a potential source of pristine freshly secreted, still unused, surfactant, since air-breathing has not been established by the baby lungs yet. Additionally, most of the experimental methodologies typically used to study PS structure at the air-liquid interface are restricted to the analysis of phospholipid-based interfacial monolayers. Here, we report a Small-Angle X-ray Scattering (SAXS) characterization of lung surfactant samples from different sources: extracted from human amniotic fluid vs. extracted from porcine lung lavage. We performed a bulk characterization of their aqueous dispersions together with an interfacial characterization using a millifluidic setup mimicking the air/liquid boundary. Both experiments point out major structural differences between the different samples, evidencing the relevance of understanding the composition/mesostructured relationship in the complex lung surfactant system." @default.
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- W3004778957 date "2020-02-01" @default.
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- W3004778957 title "Structure of Lung Surfactant from Different Sources: A Small-Angle-X-Ray Scattering (SAXS) Study" @default.
- W3004778957 doi "https://doi.org/10.1016/j.bpj.2019.11.2195" @default.
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