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- W3004803396 endingPage "80" @default.
- W3004803396 startingPage "73" @default.
- W3004803396 abstract "Heparin-induced thrombocytopenia and thrombosis is a severe immune-mediated adverse drug effect caused by the IgG antibodies to platelet factor4/heparin complexes. Activated platelets, vascular endothelium, and monocytes generate the life-threatening thrombocytopenia and thrombosis. In this review, we will update the reader on recent findings on the pathogenesis and clinical management of heparin-induced thrombocytopenia and thrombosis. Firstly, PF4/heparin complexes make IgM mediate complement activation by classical pathway. Secondly, Marginal zoneB cells play a crucial role in producing anti-PF4/heparin complex IgG antibody. Thirdly, two activation signals of platelets (protease-activated receptor 1/Fc gamma IIA receptor) were confirmed. Based on these findings, we present a potential laboratory test of HITT (receptor glycoprotein Ⅳ) and two possible treatments by using receptor inhibitors (vorapaxar/atopaxar) and IgG-degrading enzyme (streptococcus pyogenes/glutamyl endopeptidase V8/matrix metalloproteinases)." @default.
- W3004803396 created "2020-02-14" @default.
- W3004803396 creator A5003292589 @default.
- W3004803396 creator A5023770231 @default.
- W3004803396 creator A5031300978 @default.
- W3004803396 creator A5089041770 @default.
- W3004803396 date "2020-05-01" @default.
- W3004803396 modified "2023-10-04" @default.
- W3004803396 title "Pathogenesis and management of heparin-induced thrombocytopenia and thrombosis" @default.
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