Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004823553> ?p ?o ?g. }
- W3004823553 abstract "Abstract The human genome is extensively folded into 3-dimensional organization, yet the detailed 3D chromatin folding structures have not been fully visualized due to the lack of robust and ultra- resolution imaging capability. Here, we report the development of a novel electron microscopy method that combines serial block-face scanning electron microscopy with in situ hybridization (3D-EMISH) to visualize 3D chromatin folding at targeted genomic regions with ultra-resolution (5×5×30 nm in xyz dimensions, respectively). We applied 3D-EMISH to human lymphoblastoid cells at a 1.7 Mb segment of the genome and visualized a large number of distinctive 3D chromatin folding structures in high ultra-resolution. We further quantitatively characterized the reconstituted chromatin folding structures by identifying sub-domains, and uncovered a high level of heterogeneity in chromatin folding ultrastructures, suggestive of extensive dynamic fluidity in 3D chromatin states." @default.
- W3004823553 created "2020-02-14" @default.
- W3004823553 creator A5016459697 @default.
- W3004823553 creator A5020346637 @default.
- W3004823553 creator A5022244521 @default.
- W3004823553 creator A5027507163 @default.
- W3004823553 creator A5028790437 @default.
- W3004823553 creator A5034325899 @default.
- W3004823553 creator A5041988671 @default.
- W3004823553 creator A5042614541 @default.
- W3004823553 creator A5046077439 @default.
- W3004823553 creator A5047843775 @default.
- W3004823553 creator A5056673563 @default.
- W3004823553 creator A5058402592 @default.
- W3004823553 creator A5058815005 @default.
- W3004823553 creator A5059710464 @default.
- W3004823553 creator A5066356874 @default.
- W3004823553 creator A5077602092 @default.
- W3004823553 creator A5082057063 @default.
- W3004823553 creator A5090269803 @default.
- W3004823553 creator A5091175450 @default.
- W3004823553 date "2020-02-06" @default.
- W3004823553 modified "2023-10-14" @default.
- W3004823553 title "Ultrastructural Visualization of 3D Chromatin Folding Using Serial Block-Face Scanning Electron Microscopy and In Situ Hybridization (3D-EMISH)" @default.
- W3004823553 cites W1885124675 @default.
- W3004823553 cites W1973062929 @default.
- W3004823553 cites W1985621639 @default.
- W3004823553 cites W1991724532 @default.
- W3004823553 cites W1991815226 @default.
- W3004823553 cites W2008359761 @default.
- W3004823553 cites W2011463791 @default.
- W3004823553 cites W2017158973 @default.
- W3004823553 cites W2031320682 @default.
- W3004823553 cites W2038665424 @default.
- W3004823553 cites W2064537118 @default.
- W3004823553 cites W2064727535 @default.
- W3004823553 cites W2070021921 @default.
- W3004823553 cites W2078526277 @default.
- W3004823553 cites W2090037139 @default.
- W3004823553 cites W2128313472 @default.
- W3004823553 cites W2128728535 @default.
- W3004823553 cites W2132629607 @default.
- W3004823553 cites W2133161896 @default.
- W3004823553 cites W2151103935 @default.
- W3004823553 cites W2169389191 @default.
- W3004823553 cites W2195190137 @default.
- W3004823553 cites W2267962174 @default.
- W3004823553 cites W2407512034 @default.
- W3004823553 cites W2538786454 @default.
- W3004823553 cites W2739969873 @default.
- W3004823553 cites W2782774915 @default.
- W3004823553 cites W2792493536 @default.
- W3004823553 cites W2898514070 @default.
- W3004823553 cites W2991453947 @default.
- W3004823553 cites W4211071958 @default.
- W3004823553 doi "https://doi.org/10.1101/2020.02.05.935106" @default.
- W3004823553 hasPublicationYear "2020" @default.
- W3004823553 type Work @default.
- W3004823553 sameAs 3004823553 @default.
- W3004823553 citedByCount "0" @default.
- W3004823553 crossrefType "posted-content" @default.
- W3004823553 hasAuthorship W3004823553A5016459697 @default.
- W3004823553 hasAuthorship W3004823553A5020346637 @default.
- W3004823553 hasAuthorship W3004823553A5022244521 @default.
- W3004823553 hasAuthorship W3004823553A5027507163 @default.
- W3004823553 hasAuthorship W3004823553A5028790437 @default.
- W3004823553 hasAuthorship W3004823553A5034325899 @default.
- W3004823553 hasAuthorship W3004823553A5041988671 @default.
- W3004823553 hasAuthorship W3004823553A5042614541 @default.
- W3004823553 hasAuthorship W3004823553A5046077439 @default.
- W3004823553 hasAuthorship W3004823553A5047843775 @default.
- W3004823553 hasAuthorship W3004823553A5056673563 @default.
- W3004823553 hasAuthorship W3004823553A5058402592 @default.
- W3004823553 hasAuthorship W3004823553A5058815005 @default.
- W3004823553 hasAuthorship W3004823553A5059710464 @default.
- W3004823553 hasAuthorship W3004823553A5066356874 @default.
- W3004823553 hasAuthorship W3004823553A5077602092 @default.
- W3004823553 hasAuthorship W3004823553A5082057063 @default.
- W3004823553 hasAuthorship W3004823553A5090269803 @default.
- W3004823553 hasAuthorship W3004823553A5091175450 @default.
- W3004823553 hasBestOaLocation W30048235531 @default.
- W3004823553 hasConcept C104317684 @default.
- W3004823553 hasConcept C119599485 @default.
- W3004823553 hasConcept C120665830 @default.
- W3004823553 hasConcept C121332964 @default.
- W3004823553 hasConcept C12554922 @default.
- W3004823553 hasConcept C127413603 @default.
- W3004823553 hasConcept C138268822 @default.
- W3004823553 hasConcept C141231307 @default.
- W3004823553 hasConcept C147080431 @default.
- W3004823553 hasConcept C154945302 @default.
- W3004823553 hasConcept C171250308 @default.
- W3004823553 hasConcept C178790620 @default.
- W3004823553 hasConcept C185592680 @default.
- W3004823553 hasConcept C192562407 @default.
- W3004823553 hasConcept C2776545253 @default.
- W3004823553 hasConcept C2777822432 @default.
- W3004823553 hasConcept C41008148 @default.
- W3004823553 hasConcept C54355233 @default.
- W3004823553 hasConcept C552990157 @default.