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- W3004829848 abstract "Abstract The purpose of this study was to evaluate whether obstructive sleep apnea (OSA)-related chronic intermittent hypoxia (CIH) influences lung cancer progression and to elucidate the associated mechanisms in a mouse model of lung cancer. C57/BL6 mice in a CIH group were exposed to intermittent hypoxia for two weeks after tumor induction and compared with control mice (room air). Hypoxia inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF) and metastasis-related matrix metalloproteinases (MMP) were measured. The expression levels of several hypoxia-related pathway proteins including HIF-1α, Wnt/ß-catenin, the nuclear factor erythroid 2-related factor 2 (Nrf2) and mammalian target of rapamycin-ERK were measured by western blot. The number (P < 0.01) and volume (P < 0.05) of tumors were increased in the CIH group. The activity of MMP-2 was enhanced after CIH treatment. The level of VEGF was increased significantly in the CIH group (p < 0.05). ß-catenin and Nrf2 were translocated to the nucleus and the levels of downstream effectors of Wnt/ß-catenin signaling increased after IH exposure. CIH enhanced proliferative and migratory properties of tumors in a mouse model of lung cancer. ß-catenin and Nrf2 appeared to be crucial mediators of tumor growth." @default.
- W3004829848 created "2020-02-14" @default.
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- W3004829848 date "2020-02-05" @default.
- W3004829848 modified "2023-10-03" @default.
- W3004829848 title "Intermittent hypoxia exacerbates tumor progression in a mouse model of lung cancer" @default.
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- W3004829848 doi "https://doi.org/10.1038/s41598-020-58906-7" @default.
- W3004829848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7002457" @default.
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