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- W3004865862 endingPage "153" @default.
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- W3004865862 abstract "Sphingosine-1-phosphate (S1P), together with other phosphosphingolipids, has been found to regulate complex cellular function in the tumor microenvironment (TME) where it acts as a signaling molecule that participates in cell–cell communication. S1P, through intracellular and extracellular signaling, was found to promote tumor growth, angiogenesis, chemoresistance, and metastasis; it also regulates anticancer immune response, modulates inflammation, and promotes angiogenesis. Interestingly, cancer cells are capable of releasing S1P and thus modifying the behavior of the TME components in a way that contributes to tumor growth and progression. Therefore, S1P is considered an important therapeutic target, and several anticancer therapies targeting S1P signaling are being developed and tested in clinics." @default.
- W3004865862 created "2020-02-14" @default.
- W3004865862 creator A5039200324 @default.
- W3004865862 date "2020-01-01" @default.
- W3004865862 modified "2023-10-02" @default.
- W3004865862 title "S1P Signaling in the Tumor Microenvironment" @default.
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