FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004906966> ?p ?o ?g. }

• W3004906966 endingPage "11" @default.
• W3004906966 startingPage "1" @default.
• W3004906966 abstract "Objective . We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods . We combined two microarray profiling datasets from the Gene Expression Omnibus (GEO) database and RNA-seq datasets from the Cancer Genome Atlas (TCGA) database to analyze DEMs in ESCA. The clinical data from 168 ESCA patients were selected from the TCGA database to assess the prognostic role of the DEMs. The TargetScan, miRDB, miRWalk, and DIANA websites were used to predict the miRNA target genes. Functional enrichment analysis was conducted using the Database for Annotation, Visualization, and Integrated Discovery (David), and protein-protein interaction (PPI) networks were obtained using the Search Tool for the Retrieval of Interacting Genes database (STRING). Results . With cut-off criteria of <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math> and |log2FC| > 1.0, 33 overlapping DEMs, including 27 upregulated and 6 downregulated miRNAs, were identified from GEO microarray datasets and TCGA RNA-seq count datasets. The Kaplan–Meier survival analysis indicated that a three-miRNA signature (miR-1301-3p, miR-431-5p, and miR-769-5p) was significantly associated with the overall survival of ESCA patients. The results of univariate and multivariate Cox regression analysis showed that the three-miRNA signature was a potential prognostic factor in ESCA. Furthermore, the gene functional enrichment analysis revealed that the target genes of the three miRNAs participate in various cancer-related pathways, including viral carcinogenesis, forkhead box O (FoxO), vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (ErbB2), and mammalian target of rapamycin (mTOR) signaling pathways. In the PPI network, three target genes ( MAPK1 , RB1 , and CLTC ) with a high degree of connectivity were selected as hub genes. Conclusions . Our results revealed that a three-miRNA signature (miR-1301-3p, miR-431-5p, and miR-769-5p) is a potential novel prognostic biomarker for ESCA." @default.
• W3004906966 created "2020-02-14" @default.
• W3004906966 creator A5040374637 @default.
• W3004906966 creator A5049497651 @default.
• W3004906966 creator A5079469538 @default.
• W3004906966 date "2020-02-10" @default.
• W3004906966 modified "2023-10-12" @default.
• W3004906966 title "A Novel Three-miRNA Signature Identified Using Bioinformatics Predicts Survival in Esophageal Carcinoma" @default.
• W3004906966 cites W1164127144 @default.
• W3004906966 cites W1517631474 @default.
• W3004906966 cites W1671160454 @default.
• W3004906966 cites W1980143892 @default.
• W3004906966 cites W1991234161 @default.
• W3004906966 cites W2023061736 @default.
• W3004906966 cites W2047998870 @default.
• W3004906966 cites W2088894923 @default.
• W3004906966 cites W2112192177 @default.
• W3004906966 cites W2114104545 @default.
• W3004906966 cites W2118258530 @default.
• W3004906966 cites W2130116522 @default.
• W3004906966 cites W2130188666 @default.
• W3004906966 cites W2149858863 @default.
• W3004906966 cites W2158217645 @default.
• W3004906966 cites W2163275326 @default.
• W3004906966 cites W2173969854 @default.
• W3004906966 cites W2326264847 @default.
• W3004906966 cites W2341260762 @default.
• W3004906966 cites W2345362153 @default.
• W3004906966 cites W2395739137 @default.
• W3004906966 cites W2524367014 @default.
• W3004906966 cites W2538624341 @default.
• W3004906966 cites W2543054850 @default.
• W3004906966 cites W2579075310 @default.
• W3004906966 cites W2750201210 @default.
• W3004906966 cites W2772465134 @default.
• W3004906966 cites W2775401927 @default.
• W3004906966 cites W2789870028 @default.
• W3004906966 cites W2791333129 @default.
• W3004906966 cites W2800230041 @default.
• W3004906966 cites W2804447970 @default.
• W3004906966 cites W2806546829 @default.
• W3004906966 cites W2889188618 @default.
• W3004906966 cites W2889646458 @default.
• W3004906966 cites W2966563705 @default.
• W3004906966 cites W4211048478 @default.
• W3004906966 doi "https://doi.org/10.1155/2020/5973082" @default.
• W3004906966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7035545" @default.
• W3004906966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32104700" @default.
• W3004906966 hasPublicationYear "2020" @default.
• W3004906966 type Work @default.
• W3004906966 sameAs 3004906966 @default.
• W3004906966 citedByCount "7" @default.
• W3004906966 countsByYear W30049069662020 @default.
• W3004906966 countsByYear W30049069662021 @default.
• W3004906966 countsByYear W30049069662022 @default.
• W3004906966 crossrefType "journal-article" @default.
• W3004906966 hasAuthorship W3004906966A5040374637 @default.
• W3004906966 hasAuthorship W3004906966A5049497651 @default.
• W3004906966 hasAuthorship W3004906966A5079469538 @default.
• W3004906966 hasBestOaLocation W30049069661 @default.
• W3004906966 hasConcept C104317684 @default.
• W3004906966 hasConcept C119857082 @default.
• W3004906966 hasConcept C126322002 @default.
• W3004906966 hasConcept C145059251 @default.
• W3004906966 hasConcept C150194340 @default.
• W3004906966 hasConcept C158163496 @default.
• W3004906966 hasConcept C161584116 @default.
• W3004906966 hasConcept C186836561 @default.
• W3004906966 hasConcept C199163554 @default.
• W3004906966 hasConcept C2779733811 @default.
• W3004906966 hasConcept C41008148 @default.
• W3004906966 hasConcept C50382708 @default.
• W3004906966 hasConcept C54355233 @default.
• W3004906966 hasConcept C60644358 @default.
• W3004906966 hasConcept C6856738 @default.
• W3004906966 hasConcept C70721500 @default.
• W3004906966 hasConcept C71924100 @default.
• W3004906966 hasConcept C77088390 @default.
• W3004906966 hasConcept C8415881 @default.
• W3004906966 hasConcept C86803240 @default.
• W3004906966 hasConceptScore W3004906966C104317684 @default.
• W3004906966 hasConceptScore W3004906966C119857082 @default.
• W3004906966 hasConceptScore W3004906966C126322002 @default.
• W3004906966 hasConceptScore W3004906966C145059251 @default.
• W3004906966 hasConceptScore W3004906966C150194340 @default.
• W3004906966 hasConceptScore W3004906966C158163496 @default.
• W3004906966 hasConceptScore W3004906966C161584116 @default.
• W3004906966 hasConceptScore W3004906966C186836561 @default.
• W3004906966 hasConceptScore W3004906966C199163554 @default.
• W3004906966 hasConceptScore W3004906966C2779733811 @default.
• W3004906966 hasConceptScore W3004906966C41008148 @default.
• W3004906966 hasConceptScore W3004906966C50382708 @default.
• W3004906966 hasConceptScore W3004906966C54355233 @default.
• W3004906966 hasConceptScore W3004906966C60644358 @default.
• W3004906966 hasConceptScore W3004906966C6856738 @default.
• W3004906966 hasConceptScore W3004906966C70721500 @default.
• W3004906966 hasConceptScore W3004906966C71924100 @default.
• W3004906966 hasConceptScore W3004906966C77088390 @default.

• next