Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004927985> ?p ?o ?g. }
- W3004927985 endingPage "175628482090287" @default.
- W3004927985 startingPage "175628482090287" @default.
- W3004927985 abstract "The incidence and mortality of colorectal cancer (CRC) increase with age and, therefore, it is recommended that adults undergo regular CRC screening, ideally by colonoscopy, with some new guidelines recommending screening begin at 45 years. Effective bowel preparation is a critical step to a successful colonoscopy. Of concern is that older adults may have poorer quality of bowel preparation or reduced tolerability for the bowel preparation. Here, we performed a post hoc secondary analysis for the effect of age on the efficacy, tolerability, and safety of ready-to-drink sodium picosulfate, magnesium oxide, and citric acid (SPMC oral solution) bowel preparation.A phase III, randomized, assessor-blinded, multicenter, non-inferiority study was conducted comparing split-dose, low-volume SPMC oral solution with split-dose, low-volume sodium picosulfate, magnesium oxide, and citric acid powder for oral solution. A post hoc secondary analysis was performed to assess efficacy, safety, and tolerability of SPMC oral solution by age group (<50 years, 50-64 years, ⩾65 years). The prespecified primary efficacy endpoint ('responders') was the proportion of participants with 'excellent' or 'good' ratings on a modified Aronchick Scale (AS). Secondary efficacy outcomes were the quality of cleansing of the right colon as assessed by the Boston Bowel Preparation Scale (BBPS); as well as selected findings from the Mayo Clinic Bowel Prep Tolerability Questionnaire. Safety assessments included adverse events (AEs) and laboratory evaluations.Within age groups, at least 83.9% of participants were responders by the AS, and at least 91.1% of participants were responders by the BBPS in the right colon. On both scales, responder rates were highest in the youngest age group and decreased with increasing age. Greater than 88% of participants in any age group found the preparation 'easy' or 'acceptable' to ingest, with rates of 'easy' being highest in the oldest age group. No new safety signals were seen in any age group. The most commonly reported drug-related, treatment-emergent AEs were, by ascending age group, nausea (7.0%, 3.2%, 0.8%), headache (4.2%, 2.8%, 1.6%) and vomiting (2.8%, 1.2%, 0.8%).Ready-to-drink SPMC oral solution showed good efficacy of overall colon cleansing and tolerability in adults across different age groups, including those ⩾65 years.ClinicalTrials.gov identifier: NCT03017235." @default.
- W3004927985 created "2020-02-14" @default.
- W3004927985 creator A5019539239 @default.
- W3004927985 creator A5027984035 @default.
- W3004927985 creator A5028128105 @default.
- W3004927985 creator A5039453632 @default.
- W3004927985 creator A5042281578 @default.
- W3004927985 creator A5078807064 @default.
- W3004927985 date "2020-01-01" @default.
- W3004927985 modified "2023-09-26" @default.
- W3004927985 title "Efficacy, safety, and tolerability of a ready-to-drink bowel preparation: subanalysis by age from a phase III, assessor-blinded study" @default.
- W3004927985 cites W1533479258 @default.
- W3004927985 cites W1965691247 @default.
- W3004927985 cites W1980704875 @default.
- W3004927985 cites W1981998005 @default.
- W3004927985 cites W2007216121 @default.
- W3004927985 cites W2018600586 @default.
- W3004927985 cites W2025800284 @default.
- W3004927985 cites W2027546727 @default.
- W3004927985 cites W2061859021 @default.
- W3004927985 cites W2064107750 @default.
- W3004927985 cites W2065957536 @default.
- W3004927985 cites W2080775148 @default.
- W3004927985 cites W2082007140 @default.
- W3004927985 cites W2089290423 @default.
- W3004927985 cites W2105961063 @default.
- W3004927985 cites W2111147183 @default.
- W3004927985 cites W2118880120 @default.
- W3004927985 cites W2123845707 @default.
- W3004927985 cites W2147297736 @default.
- W3004927985 cites W2159078264 @default.
- W3004927985 cites W2312900426 @default.
- W3004927985 cites W2433575101 @default.
- W3004927985 cites W2511902538 @default.
- W3004927985 cites W2524309253 @default.
- W3004927985 cites W2587951293 @default.
- W3004927985 cites W2608030142 @default.
- W3004927985 cites W2619143830 @default.
- W3004927985 cites W2805885226 @default.
- W3004927985 cites W2913985135 @default.
- W3004927985 cites W2946059666 @default.
- W3004927985 cites W2962778047 @default.
- W3004927985 doi "https://doi.org/10.1177/1756284820902878" @default.
- W3004927985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7011337" @default.
- W3004927985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32095161" @default.
- W3004927985 hasPublicationYear "2020" @default.
- W3004927985 type Work @default.
- W3004927985 sameAs 3004927985 @default.
- W3004927985 citedByCount "0" @default.
- W3004927985 crossrefType "journal-article" @default.
- W3004927985 hasAuthorship W3004927985A5019539239 @default.
- W3004927985 hasAuthorship W3004927985A5027984035 @default.
- W3004927985 hasAuthorship W3004927985A5028128105 @default.
- W3004927985 hasAuthorship W3004927985A5039453632 @default.
- W3004927985 hasAuthorship W3004927985A5042281578 @default.
- W3004927985 hasAuthorship W3004927985A5078807064 @default.
- W3004927985 hasBestOaLocation W30049279851 @default.
- W3004927985 hasConcept C121608353 @default.
- W3004927985 hasConcept C126322002 @default.
- W3004927985 hasConcept C168563851 @default.
- W3004927985 hasConcept C197934379 @default.
- W3004927985 hasConcept C203092338 @default.
- W3004927985 hasConcept C2778375690 @default.
- W3004927985 hasConcept C2778435480 @default.
- W3004927985 hasConcept C3019222653 @default.
- W3004927985 hasConcept C526805850 @default.
- W3004927985 hasConcept C67761136 @default.
- W3004927985 hasConcept C71924100 @default.
- W3004927985 hasConcept C90924648 @default.
- W3004927985 hasConceptScore W3004927985C121608353 @default.
- W3004927985 hasConceptScore W3004927985C126322002 @default.
- W3004927985 hasConceptScore W3004927985C168563851 @default.
- W3004927985 hasConceptScore W3004927985C197934379 @default.
- W3004927985 hasConceptScore W3004927985C203092338 @default.
- W3004927985 hasConceptScore W3004927985C2778375690 @default.
- W3004927985 hasConceptScore W3004927985C2778435480 @default.
- W3004927985 hasConceptScore W3004927985C3019222653 @default.
- W3004927985 hasConceptScore W3004927985C526805850 @default.
- W3004927985 hasConceptScore W3004927985C67761136 @default.
- W3004927985 hasConceptScore W3004927985C71924100 @default.
- W3004927985 hasConceptScore W3004927985C90924648 @default.
- W3004927985 hasFunder F4320321723 @default.
- W3004927985 hasLocation W30049279851 @default.
- W3004927985 hasLocation W30049279852 @default.
- W3004927985 hasLocation W30049279853 @default.
- W3004927985 hasLocation W30049279854 @default.
- W3004927985 hasOpenAccess W3004927985 @default.
- W3004927985 hasPrimaryLocation W30049279851 @default.
- W3004927985 hasRelatedWork W1533479258 @default.
- W3004927985 hasRelatedWork W1707958099 @default.
- W3004927985 hasRelatedWork W1971599591 @default.
- W3004927985 hasRelatedWork W2056991677 @default.
- W3004927985 hasRelatedWork W2118880120 @default.
- W3004927985 hasRelatedWork W2333555691 @default.
- W3004927985 hasRelatedWork W2402830926 @default.
- W3004927985 hasRelatedWork W3030093884 @default.
- W3004927985 hasRelatedWork W4304757997 @default.
- W3004927985 hasRelatedWork W4310363180 @default.