FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004961655> ?p ?o ?g. }

• W3004961655 endingPage "19.2020" @default.
• W3004961655 startingPage "ENEURO.0422" @default.
• W3004961655 abstract "Propofol is the most common general anesthetic used for surgery in humans, yet its complete mechanism of action remains elusive. In addition to potentiating inhibitory synapses in the brain, propofol also impairs excitatory neurotransmission. We use electrophysiological recordings from individual glutamatergic boutons in male and female larval Drosophila melanogaster motor nerve terminals to characterize this effect. We recorded from two bouton types, which have distinct presynaptic physiology and different average numbers of release sites or active zones. We show that a clinically relevant dose of propofol (3 μ m ) impairs neurotransmitter release similarly at both bouton types by decreasing the number of active release sites by half, without affecting release probability. In contrast, an analog of propofol has no effect on glutamate release. Coexpressing a truncated syntaxin1A protein in presynaptic boutons completely blocked this effect of propofol. Overexpressing wild-type syntaxin1A in boutons also conferred a level of resistance by increasing the number of active release sites to a physiological ceiling set by the number of active zones or T-bars, and in this way counteracting the effect of propofol. These results point to the presynaptic release machinery as a target for the general anesthetic. Proportionally equivalent effects of propofol on the number of active release sites across the different bouton types suggests that glutamatergic circuits that involve smaller boutons with fewer release sites may be more vulnerable to the presynaptic effects of the drug." @default.
• W3004961655 created "2020-02-14" @default.
• W3004961655 creator A5013676374 @default.
• W3004961655 creator A5039511054 @default.
• W3004961655 creator A5042734723 @default.
• W3004961655 creator A5044534390 @default.
• W3004961655 creator A5051729485 @default.
• W3004961655 creator A5059017458 @default.
• W3004961655 creator A5075309572 @default.
• W3004961655 creator A5086926544 @default.
• W3004961655 date "2020-01-01" @default.
• W3004961655 modified "2023-10-11" @default.
• W3004961655 title "Proportional Downscaling of Glutamatergic Release Sites by the General Anesthetic Propofol at<i>Drosophila</i>Motor Nerve Terminals" @default.
• W3004961655 cites W1506710296 @default.
• W3004961655 cites W1511449528 @default.
• W3004961655 cites W1514853588 @default.
• W3004961655 cites W1594046881 @default.
• W3004961655 cites W1675038283 @default.
• W3004961655 cites W1845163922 @default.
• W3004961655 cites W190691719 @default.
• W3004961655 cites W1934152683 @default.
• W3004961655 cites W1969915478 @default.
• W3004961655 cites W1971078075 @default.
• W3004961655 cites W1972529694 @default.
• W3004961655 cites W1978348024 @default.
• W3004961655 cites W1988278060 @default.
• W3004961655 cites W1991218496 @default.
• W3004961655 cites W2001637662 @default.
• W3004961655 cites W2004727131 @default.
• W3004961655 cites W2009441114 @default.
• W3004961655 cites W2013649634 @default.
• W3004961655 cites W2014166913 @default.
• W3004961655 cites W2021327095 @default.
• W3004961655 cites W2021774924 @default.
• W3004961655 cites W2028833397 @default.
• W3004961655 cites W2032393127 @default.
• W3004961655 cites W2047730591 @default.
• W3004961655 cites W2053050328 @default.
• W3004961655 cites W2055518516 @default.
• W3004961655 cites W2057591584 @default.
• W3004961655 cites W2062347154 @default.
• W3004961655 cites W2084840477 @default.
• W3004961655 cites W2093812780 @default.
• W3004961655 cites W2094846297 @default.
• W3004961655 cites W2102548112 @default.
• W3004961655 cites W2106081526 @default.
• W3004961655 cites W2111447389 @default.
• W3004961655 cites W2116095859 @default.
• W3004961655 cites W2116895182 @default.
• W3004961655 cites W2129317350 @default.
• W3004961655 cites W2156428325 @default.
• W3004961655 cites W2165603422 @default.
• W3004961655 cites W2167150855 @default.
• W3004961655 cites W2171310450 @default.
• W3004961655 cites W2172212230 @default.
• W3004961655 cites W2202281942 @default.
• W3004961655 cites W2578173289 @default.
• W3004961655 cites W2592481914 @default.
• W3004961655 cites W2599708134 @default.
• W3004961655 cites W2618285320 @default.
• W3004961655 cites W2783479578 @default.
• W3004961655 cites W2792620637 @default.
• W3004961655 cites W2802878745 @default.
• W3004961655 cites W2805863058 @default.
• W3004961655 cites W2905408411 @default.
• W3004961655 cites W2914153576 @default.
• W3004961655 cites W2916286541 @default.
• W3004961655 cites W2943731397 @default.
• W3004961655 cites W2947596811 @default.
• W3004961655 cites W2962855124 @default.
• W3004961655 doi "https://doi.org/10.1523/eneuro.0422-19.2020" @default.
• W3004961655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7053172" @default.
• W3004961655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32019872" @default.
• W3004961655 hasPublicationYear "2020" @default.
• W3004961655 type Work @default.
• W3004961655 sameAs 3004961655 @default.
• W3004961655 citedByCount "11" @default.
• W3004961655 countsByYear W30049616552020 @default.
• W3004961655 countsByYear W30049616552021 @default.
• W3004961655 countsByYear W30049616552022 @default.
• W3004961655 countsByYear W30049616552023 @default.
• W3004961655 crossrefType "journal-article" @default.
• W3004961655 hasAuthorship W3004961655A5013676374 @default.
• W3004961655 hasAuthorship W3004961655A5039511054 @default.
• W3004961655 hasAuthorship W3004961655A5042734723 @default.
• W3004961655 hasAuthorship W3004961655A5044534390 @default.
• W3004961655 hasAuthorship W3004961655A5051729485 @default.
• W3004961655 hasAuthorship W3004961655A5059017458 @default.
• W3004961655 hasAuthorship W3004961655A5075309572 @default.
• W3004961655 hasAuthorship W3004961655A5086926544 @default.
• W3004961655 hasBestOaLocation W30049616551 @default.
• W3004961655 hasConcept C104317684 @default.
• W3004961655 hasConcept C112592302 @default.
• W3004961655 hasConcept C169760540 @default.
• W3004961655 hasConcept C170493617 @default.
• W3004961655 hasConcept C17077164 @default.
• W3004961655 hasConcept C200170125 @default.
• W3004961655 hasConcept C2776219046 @default.

• next