Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004974539> ?p ?o ?g. }
- W3004974539 abstract "The development of new drugs is multidisciplinary and systematic work. High-throughput techniques based on -omics have driven the discovery of biomarkers in diseases and therapeutic targets of drugs. A transcriptome is the complete set of all RNAs transcribed by certain tissues or cells at a specific stage of development or physiological condition. Transcriptome research can demonstrate gene functions and structures from the whole level and reveal the molecular mechanism of specific biological processes in diseases. Currently, gene expression microarray and high-throughput RNA-sequencing have been widely used in biological, medical, clinical, and drug research. The former has been applied in drug screening and biomarker detection of drugs due to its high throughput, fast detection speed, simple analysis, and relatively low price. With the further development of detection technology and the improvement of analytical methods, the detection flux of RNA-seq is much higher but the price is lower, hence it has powerful advantages in detecting biomarkers and drug discovery. Compared with the traditional RNA-seq, scRNA-seq has higher accuracy and efficiency, especially the single-cell level of gene expression pattern analysis can provide more information for drug and biomarker discovery. Therefore, (sc)RNA-seq has broader application prospects, especially in the field of drug discovery. In this overview, we will review the application of these technologies in drug, especially in natural drug and biomarker discovery and development. Emerging applications of scRNA-seq and the third generation RNA-sequencing tools are also discussed." @default.
- W3004974539 created "2020-02-14" @default.
- W3004974539 creator A5004512291 @default.
- W3004974539 creator A5017541508 @default.
- W3004974539 creator A5018284299 @default.
- W3004974539 creator A5036702416 @default.
- W3004974539 creator A5042039581 @default.
- W3004974539 creator A5044817441 @default.
- W3004974539 creator A5064398610 @default.
- W3004974539 creator A5085318175 @default.
- W3004974539 date "2020-02-05" @default.
- W3004974539 modified "2023-10-17" @default.
- W3004974539 title "High-Throughput Transcriptome Profiling in Drug and Biomarker Discovery" @default.
- W3004974539 cites W1509405108 @default.
- W3004974539 cites W1550510223 @default.
- W3004974539 cites W1558022610 @default.
- W3004974539 cites W1580018887 @default.
- W3004974539 cites W1970156673 @default.
- W3004974539 cites W1972072347 @default.
- W3004974539 cites W1980928891 @default.
- W3004974539 cites W1981509058 @default.
- W3004974539 cites W1988391018 @default.
- W3004974539 cites W1990965835 @default.
- W3004974539 cites W1995548146 @default.
- W3004974539 cites W2001620383 @default.
- W3004974539 cites W2004280138 @default.
- W3004974539 cites W2011472222 @default.
- W3004974539 cites W2015029046 @default.
- W3004974539 cites W2019552331 @default.
- W3004974539 cites W2019955264 @default.
- W3004974539 cites W2041943305 @default.
- W3004974539 cites W2042475019 @default.
- W3004974539 cites W2043278104 @default.
- W3004974539 cites W2050163545 @default.
- W3004974539 cites W2060601646 @default.
- W3004974539 cites W2061607005 @default.
- W3004974539 cites W2065709676 @default.
- W3004974539 cites W2066344493 @default.
- W3004974539 cites W2067655607 @default.
- W3004974539 cites W2069955857 @default.
- W3004974539 cites W2077183006 @default.
- W3004974539 cites W2082239705 @default.
- W3004974539 cites W2084752736 @default.
- W3004974539 cites W2084942072 @default.
- W3004974539 cites W2088226047 @default.
- W3004974539 cites W2094652176 @default.
- W3004974539 cites W2099851046 @default.
- W3004974539 cites W2099855466 @default.
- W3004974539 cites W2102212449 @default.
- W3004974539 cites W2105776281 @default.
- W3004974539 cites W2107680358 @default.
- W3004974539 cites W2111976640 @default.
- W3004974539 cites W2116483002 @default.
- W3004974539 cites W2117637538 @default.
- W3004974539 cites W2121690903 @default.
- W3004974539 cites W2121901998 @default.
- W3004974539 cites W2125040336 @default.
- W3004974539 cites W2127420801 @default.
- W3004974539 cites W2130940803 @default.
- W3004974539 cites W2133811295 @default.
- W3004974539 cites W2135937351 @default.
- W3004974539 cites W2139838862 @default.
- W3004974539 cites W2142284341 @default.
- W3004974539 cites W2142396630 @default.
- W3004974539 cites W2142845988 @default.
- W3004974539 cites W2144430639 @default.
- W3004974539 cites W2145156694 @default.
- W3004974539 cites W2149573463 @default.
- W3004974539 cites W2154068087 @default.
- W3004974539 cites W2154431984 @default.
- W3004974539 cites W2162554386 @default.
- W3004974539 cites W2170151897 @default.
- W3004974539 cites W2171501288 @default.
- W3004974539 cites W2231664225 @default.
- W3004974539 cites W2248179576 @default.
- W3004974539 cites W2256742438 @default.
- W3004974539 cites W2276765849 @default.
- W3004974539 cites W2288153033 @default.
- W3004974539 cites W2290431143 @default.
- W3004974539 cites W2323860656 @default.
- W3004974539 cites W2514158339 @default.
- W3004974539 cites W2520714212 @default.
- W3004974539 cites W2521378570 @default.
- W3004974539 cites W2545226662 @default.
- W3004974539 cites W2562281683 @default.
- W3004974539 cites W2564176045 @default.
- W3004974539 cites W2570618306 @default.
- W3004974539 cites W2576417045 @default.
- W3004974539 cites W2582626148 @default.
- W3004974539 cites W2604677716 @default.
- W3004974539 cites W2606038108 @default.
- W3004974539 cites W2736651304 @default.
- W3004974539 cites W2747749960 @default.
- W3004974539 cites W2769960210 @default.
- W3004974539 cites W2804728964 @default.
- W3004974539 cites W2806637668 @default.
- W3004974539 cites W2809476563 @default.
- W3004974539 cites W2885544889 @default.
- W3004974539 cites W2889236955 @default.
- W3004974539 cites W2896822135 @default.