Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005002468> ?p ?o ?g. }
- W3005002468 endingPage "162" @default.
- W3005002468 startingPage "162" @default.
- W3005002468 abstract "The hippocampus is involved in learning and memory and undergoes significant growth and maturation during the neonatal period. Environmental insults during this developmental timeframe can have lasting effects on brain structure and function. This study assessed hippocampal DNA methylation and gene transcription from two independent studies reporting reduced cognitive development stemming from early life environmental insults (iron deficiency and porcine reproductive and respiratory syndrome virus (PRRSv) infection) using porcine biomedical models. In total, 420 differentially expressed genes (DEGs) were identified between the reduced cognition and control groups, including genes involved in neurodevelopment and function. Gene ontology (GO) terms enriched for DEGs were associated with immune responses, angiogenesis, and cellular development. In addition, 116 differentially methylated regions (DMRs) were identified, which overlapped 125 genes. While no GO terms were enriched for genes overlapping DMRs, many of these genes are known to be involved in neurodevelopment and function, angiogenesis, and immunity. The observed altered methylation and expression of genes involved in neurological function suggest reduced cognition in response to early life environmental insults is due to altered cholinergic signaling and calcium regulation. Finally, two DMRs overlapped with two DEGs, VWF and LRRC32, which are associated with blood brain barrier permeability and regulatory T-cell activation, respectively. These results support the role of altered hippocampal DNA methylation and gene expression in early life environmentally-induced reductions in cognitive development across independent studies." @default.
- W3005002468 created "2020-02-14" @default.
- W3005002468 creator A5009153015 @default.
- W3005002468 creator A5016847814 @default.
- W3005002468 creator A5020556428 @default.
- W3005002468 creator A5025255020 @default.
- W3005002468 creator A5038827888 @default.
- W3005002468 creator A5059550426 @default.
- W3005002468 creator A5062697236 @default.
- W3005002468 creator A5062905406 @default.
- W3005002468 creator A5075978861 @default.
- W3005002468 creator A5077854507 @default.
- W3005002468 date "2020-02-04" @default.
- W3005002468 modified "2023-10-13" @default.
- W3005002468 title "Altered Hippocampal Epigenetic Regulation Underlying Reduced Cognitive Development in Response to Early Life Environmental Insults" @default.
- W3005002468 cites W1520812622 @default.
- W3005002468 cites W1557716287 @default.
- W3005002468 cites W1576438768 @default.
- W3005002468 cites W1583993469 @default.
- W3005002468 cites W162280000 @default.
- W3005002468 cites W167252981 @default.
- W3005002468 cites W1723906651 @default.
- W3005002468 cites W1798056883 @default.
- W3005002468 cites W1873376748 @default.
- W3005002468 cites W1966019489 @default.
- W3005002468 cites W1966505684 @default.
- W3005002468 cites W1973605976 @default.
- W3005002468 cites W1974625950 @default.
- W3005002468 cites W1976060210 @default.
- W3005002468 cites W1977370225 @default.
- W3005002468 cites W1980812175 @default.
- W3005002468 cites W1981147791 @default.
- W3005002468 cites W1985334684 @default.
- W3005002468 cites W1989633554 @default.
- W3005002468 cites W1992173856 @default.
- W3005002468 cites W1997758505 @default.
- W3005002468 cites W2003954715 @default.
- W3005002468 cites W2004854973 @default.
- W3005002468 cites W2005676577 @default.
- W3005002468 cites W2007217254 @default.
- W3005002468 cites W2011747578 @default.
- W3005002468 cites W2012955383 @default.
- W3005002468 cites W2014318402 @default.
- W3005002468 cites W2014560168 @default.
- W3005002468 cites W2015535639 @default.
- W3005002468 cites W2017043478 @default.
- W3005002468 cites W2018688645 @default.
- W3005002468 cites W2018922170 @default.
- W3005002468 cites W2021090329 @default.
- W3005002468 cites W2021880581 @default.
- W3005002468 cites W2026405123 @default.
- W3005002468 cites W2026813655 @default.
- W3005002468 cites W2027276972 @default.
- W3005002468 cites W2030108859 @default.
- W3005002468 cites W2032215155 @default.
- W3005002468 cites W2036260794 @default.
- W3005002468 cites W2037194302 @default.
- W3005002468 cites W2037852973 @default.
- W3005002468 cites W2048514487 @default.
- W3005002468 cites W2049442567 @default.
- W3005002468 cites W2051465150 @default.
- W3005002468 cites W2054021999 @default.
- W3005002468 cites W2056491411 @default.
- W3005002468 cites W2066808465 @default.
- W3005002468 cites W2067004457 @default.
- W3005002468 cites W2069958148 @default.
- W3005002468 cites W2071659396 @default.
- W3005002468 cites W2076577677 @default.
- W3005002468 cites W2083906081 @default.
- W3005002468 cites W2085435800 @default.
- W3005002468 cites W2086099578 @default.
- W3005002468 cites W2090596338 @default.
- W3005002468 cites W2091053629 @default.
- W3005002468 cites W2091505015 @default.
- W3005002468 cites W2092863710 @default.
- W3005002468 cites W2097364929 @default.
- W3005002468 cites W2101586949 @default.
- W3005002468 cites W2103017472 @default.
- W3005002468 cites W2106524861 @default.
- W3005002468 cites W2108500173 @default.
- W3005002468 cites W2109340786 @default.
- W3005002468 cites W2110831253 @default.
- W3005002468 cites W2115809399 @default.
- W3005002468 cites W2116467526 @default.
- W3005002468 cites W2118548854 @default.
- W3005002468 cites W2118685291 @default.
- W3005002468 cites W2122825543 @default.
- W3005002468 cites W2130907138 @default.
- W3005002468 cites W2133173415 @default.
- W3005002468 cites W2137129753 @default.
- W3005002468 cites W2140422012 @default.
- W3005002468 cites W2141458291 @default.
- W3005002468 cites W2143517695 @default.
- W3005002468 cites W2156665896 @default.
- W3005002468 cites W2156779369 @default.
- W3005002468 cites W2157152722 @default.
- W3005002468 cites W2159724619 @default.
- W3005002468 cites W2160373707 @default.