Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005007095> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3005007095 endingPage "569a" @default.
- W3005007095 startingPage "569a" @default.
- W3005007095 abstract "Heart failure (HF) is associated with diminished amplitude and slower kinetics of the Ca2+ transient in ventricular myocytes. Loss of t-tubules geometrically uncouples voltage gated Ca2+ channels (which carry the Ca2+ current -ICa) from RyR2 Ca2+ release channels on the sarcoplasmic reticulum. Changes in action potential (AP) morphology, due to altered K+ currents, further reduce peak ICa and increase heterogeneity in Ca2+ release. We recently reported that partially inhibiting ICa in non-failing cardiac myocytes increased the occurrence of “late Ca2+ sparks” (LCS) which prolonged the Ca2+ transient decay. Here we tested the hypothesis that LCS are similarly increased in HF by changes in t-tubules and/or altered AP morphology, and that they may contribute to arrhythmogenesis via inward Na+/Ca2+ exchange (NCX) current. HF was developed in rabbits after coronary artery ligation. Myocytes were isolated by collagenase digestion of the heart and whole cell patch-clamped using pipettes containing Fluo-4 (50 µM). Myocytes were imaged on a laser scanning confocal microscope (LSM880) in line-scanning mode. Ca2+ release was more dyssynchronous and more LCS were detected during the Ca2+ transient decay in cells from HF rabbits compared to non-failing control rabbits. Early afterdepolarizations (EADs) occurred in some HF cells, coinciding with greatly increased LCS frequency. Consistent with experimental data, a multiscale ventricular myocyte computer model showed that the increased LCS could increase inward NCX current sufficiently to drive membrane oscillations. These data indicate LCS are an arrhythmogenic substrate in failing cardiac myocytes and that controlling repolarization abnormalities may be beneficial for rescuing contractility and decreasing arrhythmias." @default.
- W3005007095 created "2020-02-14" @default.
- W3005007095 creator A5003117785 @default.
- W3005007095 creator A5010465278 @default.
- W3005007095 creator A5037737415 @default.
- W3005007095 creator A5043195980 @default.
- W3005007095 date "2020-02-01" @default.
- W3005007095 modified "2023-09-26" @default.
- W3005007095 title "Late Ca2+Spark Arrhythmogenesis in Failing Cardiac Myocytes" @default.
- W3005007095 doi "https://doi.org/10.1016/j.bpj.2019.11.3097" @default.
- W3005007095 hasPublicationYear "2020" @default.
- W3005007095 type Work @default.
- W3005007095 sameAs 3005007095 @default.
- W3005007095 citedByCount "1" @default.
- W3005007095 countsByYear W30050070952023 @default.
- W3005007095 crossrefType "journal-article" @default.
- W3005007095 hasAuthorship W3005007095A5003117785 @default.
- W3005007095 hasAuthorship W3005007095A5010465278 @default.
- W3005007095 hasAuthorship W3005007095A5037737415 @default.
- W3005007095 hasAuthorship W3005007095A5043195980 @default.
- W3005007095 hasBestOaLocation W30050070951 @default.
- W3005007095 hasConcept C12554922 @default.
- W3005007095 hasConcept C126322002 @default.
- W3005007095 hasConcept C134018914 @default.
- W3005007095 hasConcept C146403970 @default.
- W3005007095 hasConcept C155730078 @default.
- W3005007095 hasConcept C158617107 @default.
- W3005007095 hasConcept C164705383 @default.
- W3005007095 hasConcept C181911157 @default.
- W3005007095 hasConcept C185263204 @default.
- W3005007095 hasConcept C185592680 @default.
- W3005007095 hasConcept C207200792 @default.
- W3005007095 hasConcept C4141045 @default.
- W3005007095 hasConcept C55493867 @default.
- W3005007095 hasConcept C71924100 @default.
- W3005007095 hasConcept C86803240 @default.
- W3005007095 hasConceptScore W3005007095C12554922 @default.
- W3005007095 hasConceptScore W3005007095C126322002 @default.
- W3005007095 hasConceptScore W3005007095C134018914 @default.
- W3005007095 hasConceptScore W3005007095C146403970 @default.
- W3005007095 hasConceptScore W3005007095C155730078 @default.
- W3005007095 hasConceptScore W3005007095C158617107 @default.
- W3005007095 hasConceptScore W3005007095C164705383 @default.
- W3005007095 hasConceptScore W3005007095C181911157 @default.
- W3005007095 hasConceptScore W3005007095C185263204 @default.
- W3005007095 hasConceptScore W3005007095C185592680 @default.
- W3005007095 hasConceptScore W3005007095C207200792 @default.
- W3005007095 hasConceptScore W3005007095C4141045 @default.
- W3005007095 hasConceptScore W3005007095C55493867 @default.
- W3005007095 hasConceptScore W3005007095C71924100 @default.
- W3005007095 hasConceptScore W3005007095C86803240 @default.
- W3005007095 hasIssue "3" @default.
- W3005007095 hasLocation W30050070951 @default.
- W3005007095 hasOpenAccess W3005007095 @default.
- W3005007095 hasPrimaryLocation W30050070951 @default.
- W3005007095 hasRelatedWork W1977151728 @default.
- W3005007095 hasRelatedWork W2033129782 @default.
- W3005007095 hasRelatedWork W2073543028 @default.
- W3005007095 hasRelatedWork W2081271266 @default.
- W3005007095 hasRelatedWork W2133154669 @default.
- W3005007095 hasRelatedWork W2138039832 @default.
- W3005007095 hasRelatedWork W2148347482 @default.
- W3005007095 hasRelatedWork W2157651064 @default.
- W3005007095 hasRelatedWork W2400752963 @default.
- W3005007095 hasRelatedWork W2310752842 @default.
- W3005007095 hasVolume "118" @default.
- W3005007095 isParatext "false" @default.
- W3005007095 isRetracted "false" @default.
- W3005007095 magId "3005007095" @default.
- W3005007095 workType "article" @default.