FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005030673> ?p ?o ?g. }

• W3005030673 abstract "The gut microbiota is important for maintaining the integrity of the intestinal barrier, promoting immunological tolerance and carrying out metabolic activities that have not evolved in hosts. Intestinal dysbiosis is associated with chronic kidney disease and probiotic supplementation has been shown to be beneficial. However, it is not known whether gut microorganisms‑specifically, lactic acid bacteria (LAB) can protect against acute kidney injury (AKI). To address this issue, the present study investigated the effects of Lactobacillus salivarius BP121, an intestinal LAB isolated from the feces of newborns, in a rat model of cisplatin‑induced AKI and also in Caco‑2 human intestinal epithelial cells. BP121 prevented cisplatin‑induced AKI in rats, as demonstrated by decreases in inflammation and oxidative stress in kidney tissue and in serum levels of uremic toxins such as indoxyl sulfate (IS) and p‑cresol sulfate (PCS). BP121 also reduced intestinal permeability, as determined using fluorescein isothiocyanate‑dextran by immunohistochemical detection of tight junction (TJ) proteins such as zona occludens‑1 and occludin. The abundance of Lactobacillus spp., which are beneficial intestinal flora, was increased by BP121; this was accompanied by an increase in the concentrations of short‑chain fatty acids in feces. Additionally, H2O2‑induced TJ protein damage was reduced in Caco‑2 cells treated with BP121 culture supernatant, an effect that was reversed by the 5' AMP‑activated protein kinase (AMPK) inhibitor Compound C and Toll‑like receptor (TLR)4 inhibitor TLR4‑IN‑C34. In conclusion, this study demonstrated that L. salivarius BP121 protects against cisplatin‑induced AKI by decreasing inflammation and oxidative stress and this renoprotective effect is partially mediated by modulating the gut environment and thereby suppressing IS and PCS production as well as by regulating AMPK and TLR4 dependent TJ assembly." @default.
• W3005030673 created "2020-02-14" @default.
• W3005030673 creator A5024324329 @default.
• W3005030673 creator A5052221811 @default.
• W3005030673 creator A5052279132 @default.
• W3005030673 creator A5058553872 @default.
• W3005030673 creator A5063780736 @default.
• W3005030673 creator A5065042253 @default.
• W3005030673 creator A5066292012 @default.
• W3005030673 creator A5072359871 @default.
• W3005030673 creator A5080585345 @default.
• W3005030673 date "2020-02-10" @default.
• W3005030673 modified "2023-10-16" @default.
• W3005030673 title "Lactobacillus salivarius BP121 prevents cisplatin‑induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p‑cresol sulfate via alleviating dysbiosis" @default.
• W3005030673 cites W1593014745 @default.
• W3005030673 cites W1741860215 @default.
• W3005030673 cites W1827522486 @default.
• W3005030673 cites W1901435509 @default.
• W3005030673 cites W1965985248 @default.
• W3005030673 cites W1973464887 @default.
• W3005030673 cites W1973868921 @default.
• W3005030673 cites W1974693247 @default.
• W3005030673 cites W1976454725 @default.
• W3005030673 cites W1983965827 @default.
• W3005030673 cites W2001938165 @default.
• W3005030673 cites W2002138274 @default.
• W3005030673 cites W2002811300 @default.
• W3005030673 cites W2029228973 @default.
• W3005030673 cites W2041341409 @default.
• W3005030673 cites W2072288157 @default.
• W3005030673 cites W2072317939 @default.
• W3005030673 cites W2073332363 @default.
• W3005030673 cites W2076343978 @default.
• W3005030673 cites W2076384470 @default.
• W3005030673 cites W2078923271 @default.
• W3005030673 cites W2089489898 @default.
• W3005030673 cites W2090925778 @default.
• W3005030673 cites W2101272036 @default.
• W3005030673 cites W2104975759 @default.
• W3005030673 cites W2106052023 @default.
• W3005030673 cites W2113582196 @default.
• W3005030673 cites W2114889530 @default.
• W3005030673 cites W2127826587 @default.
• W3005030673 cites W2127906539 @default.
• W3005030673 cites W2136377456 @default.
• W3005030673 cites W2140958385 @default.
• W3005030673 cites W2146081758 @default.
• W3005030673 cites W2161751637 @default.
• W3005030673 cites W2162432406 @default.
• W3005030673 cites W2165257283 @default.
• W3005030673 cites W2169115393 @default.
• W3005030673 cites W2169733549 @default.
• W3005030673 cites W2233632661 @default.
• W3005030673 cites W2289081247 @default.
• W3005030673 cites W2319098039 @default.
• W3005030673 cites W2340304486 @default.
• W3005030673 cites W2581608699 @default.
• W3005030673 cites W2612161536 @default.
• W3005030673 cites W2616526198 @default.
• W3005030673 cites W26696277 @default.
• W3005030673 cites W2892367196 @default.
• W3005030673 cites W2906983625 @default.
• W3005030673 cites W2912903555 @default.
• W3005030673 cites W2914967296 @default.
• W3005030673 cites W2921966151 @default.
• W3005030673 cites W2923723307 @default.
• W3005030673 cites W4255704287 @default.
• W3005030673 doi "https://doi.org/10.3892/ijmm.2020.4495" @default.
• W3005030673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7053870" @default.
• W3005030673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32124946" @default.
• W3005030673 hasPublicationYear "2020" @default.
• W3005030673 type Work @default.
• W3005030673 sameAs 3005030673 @default.
• W3005030673 citedByCount "37" @default.
• W3005030673 countsByYear W30050306732020 @default.
• W3005030673 countsByYear W30050306732021 @default.
• W3005030673 countsByYear W30050306732022 @default.
• W3005030673 countsByYear W30050306732023 @default.
• W3005030673 crossrefType "journal-article" @default.
• W3005030673 hasAuthorship W3005030673A5024324329 @default.
• W3005030673 hasAuthorship W3005030673A5052221811 @default.
• W3005030673 hasAuthorship W3005030673A5052279132 @default.
• W3005030673 hasAuthorship W3005030673A5058553872 @default.
• W3005030673 hasAuthorship W3005030673A5063780736 @default.
• W3005030673 hasAuthorship W3005030673A5065042253 @default.
• W3005030673 hasAuthorship W3005030673A5066292012 @default.
• W3005030673 hasAuthorship W3005030673A5072359871 @default.
• W3005030673 hasAuthorship W3005030673A5080585345 @default.
• W3005030673 hasBestOaLocation W30050306731 @default.
• W3005030673 hasConcept C100544194 @default.
• W3005030673 hasConcept C134018914 @default.
• W3005030673 hasConcept C177779419 @default.
• W3005030673 hasConcept C185592680 @default.
• W3005030673 hasConcept C203014093 @default.
• W3005030673 hasConcept C2775962179 @default.
• W3005030673 hasConcept C2776151105 @default.
• W3005030673 hasConcept C2776914184 @default.
• W3005030673 hasConcept C2777165150 @default.
• W3005030673 hasConcept C2780091579 @default.
• W3005030673 hasConcept C2780206646 @default.

• next