Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005046878> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3005046878 endingPage "4541" @default.
- W3005046878 startingPage "4535" @default.
- W3005046878 abstract "Abstract The cardioprotection of remote ischemic preconditioning (RIPC) is abolished under propofol maintained anesthesia. Transient receptor potential vanilloid 1 (TRPV1) channel is present in the heart, and its activation could induce cardioprotection. Therefore, we tested whether the anesthetic propofol administration phase interfered with the RIPC‐induced cardioprotection, and RIPC‐induced cardioprotection via the cardiac TRPV1 channel. Male Sprague‐Dawley rats were subjected to myocardial 30 minutes of ischemia followed by 2 hours of reperfusion. RIPC consisted of three cycles of 5‐minute ischemia/reperfusion applied to a hindlimb. Propofol infusion at 12 mg/kg/h was commenced either at 10 minutes before the start of RIPC in the P‐pre + RIPC group, or immediately after myocardial ischemia at the onset of reperfusion (P‐post + RIPC) while performing RIPC. These two propofol infusion regimes were applied to another two grou bs without RIPC (P‐pre and P‐post groups). Infarct size (IS) was assessed by triphenyltetrazolium staining. Heart TRPV1 expression was detected by Western blot and immunofluorescence. RIPC significantly reduced myocardial IS compared with the control group (36.7 ± 3% versus 57.2 ± 4%; P < .01). When propofol was started before RIPC, the IS sparing effect of RIPC was completely abolished. However, propofol infusion starting immediately after myocardial ischemia did not affect RIPC‐induced cardioprotection. TRPV1 expression significant increase after RIPC, then propofol inhibited the TRPV1 activation of RIPC if given before RIPC but not after. Our results suggest that the timing of propofol administration is critical to preserve the cardioprotection of RIPC. Propofol might cancel RIPC‐induced cardioprotection via the cardiac TRPV1 receptor." @default.
- W3005046878 created "2020-02-14" @default.
- W3005046878 creator A5017590806 @default.
- W3005046878 creator A5030600034 @default.
- W3005046878 creator A5034958459 @default.
- W3005046878 creator A5038936840 @default.
- W3005046878 creator A5039146544 @default.
- W3005046878 creator A5047165235 @default.
- W3005046878 creator A5083721105 @default.
- W3005046878 date "2020-02-07" @default.
- W3005046878 modified "2023-09-30" @default.
- W3005046878 title "The timing of propofol administration affects the effectiveness of remote ischemic preconditioning induced cardioprotection in rats" @default.
- W3005046878 cites W1824177875 @default.
- W3005046878 cites W1854923616 @default.
- W3005046878 cites W1970150649 @default.
- W3005046878 cites W1986700107 @default.
- W3005046878 cites W1997349469 @default.
- W3005046878 cites W2081972439 @default.
- W3005046878 cites W2098712289 @default.
- W3005046878 cites W2114205159 @default.
- W3005046878 cites W2137572745 @default.
- W3005046878 cites W2171638361 @default.
- W3005046878 cites W2324735693 @default.
- W3005046878 cites W2325867355 @default.
- W3005046878 cites W2332389703 @default.
- W3005046878 cites W2524439359 @default.
- W3005046878 cites W2525951333 @default.
- W3005046878 cites W2591478754 @default.
- W3005046878 cites W2739907642 @default.
- W3005046878 cites W2761113424 @default.
- W3005046878 cites W2766306028 @default.
- W3005046878 cites W2791512588 @default.
- W3005046878 cites W2793988287 @default.
- W3005046878 cites W2909151961 @default.
- W3005046878 cites W2739681005 @default.
- W3005046878 doi "https://doi.org/10.1002/jcb.29671" @default.
- W3005046878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32030809" @default.
- W3005046878 hasPublicationYear "2020" @default.
- W3005046878 type Work @default.
- W3005046878 sameAs 3005046878 @default.
- W3005046878 citedByCount "9" @default.
- W3005046878 countsByYear W30050468782020 @default.
- W3005046878 countsByYear W30050468782021 @default.
- W3005046878 countsByYear W30050468782022 @default.
- W3005046878 countsByYear W30050468782023 @default.
- W3005046878 crossrefType "journal-article" @default.
- W3005046878 hasAuthorship W3005046878A5017590806 @default.
- W3005046878 hasAuthorship W3005046878A5030600034 @default.
- W3005046878 hasAuthorship W3005046878A5034958459 @default.
- W3005046878 hasAuthorship W3005046878A5038936840 @default.
- W3005046878 hasAuthorship W3005046878A5039146544 @default.
- W3005046878 hasAuthorship W3005046878A5047165235 @default.
- W3005046878 hasAuthorship W3005046878A5083721105 @default.
- W3005046878 hasConcept C126322002 @default.
- W3005046878 hasConcept C155164980 @default.
- W3005046878 hasConcept C160145004 @default.
- W3005046878 hasConcept C170493617 @default.
- W3005046878 hasConcept C2776277131 @default.
- W3005046878 hasConcept C2779311647 @default.
- W3005046878 hasConcept C2779676291 @default.
- W3005046878 hasConcept C42219234 @default.
- W3005046878 hasConcept C541997718 @default.
- W3005046878 hasConcept C71924100 @default.
- W3005046878 hasConcept C98274493 @default.
- W3005046878 hasConceptScore W3005046878C126322002 @default.
- W3005046878 hasConceptScore W3005046878C155164980 @default.
- W3005046878 hasConceptScore W3005046878C160145004 @default.
- W3005046878 hasConceptScore W3005046878C170493617 @default.
- W3005046878 hasConceptScore W3005046878C2776277131 @default.
- W3005046878 hasConceptScore W3005046878C2779311647 @default.
- W3005046878 hasConceptScore W3005046878C2779676291 @default.
- W3005046878 hasConceptScore W3005046878C42219234 @default.
- W3005046878 hasConceptScore W3005046878C541997718 @default.
- W3005046878 hasConceptScore W3005046878C71924100 @default.
- W3005046878 hasConceptScore W3005046878C98274493 @default.
- W3005046878 hasFunder F4320321001 @default.
- W3005046878 hasIssue "11" @default.
- W3005046878 hasLocation W30050468781 @default.
- W3005046878 hasOpenAccess W3005046878 @default.
- W3005046878 hasPrimaryLocation W30050468781 @default.
- W3005046878 hasRelatedWork W14376166 @default.
- W3005046878 hasRelatedWork W152752909 @default.
- W3005046878 hasRelatedWork W1539227406 @default.
- W3005046878 hasRelatedWork W1996647731 @default.
- W3005046878 hasRelatedWork W2065337698 @default.
- W3005046878 hasRelatedWork W2137320652 @default.
- W3005046878 hasRelatedWork W2139141364 @default.
- W3005046878 hasRelatedWork W2187061801 @default.
- W3005046878 hasRelatedWork W2249775642 @default.
- W3005046878 hasRelatedWork W2968635550 @default.
- W3005046878 hasVolume "121" @default.
- W3005046878 isParatext "false" @default.
- W3005046878 isRetracted "false" @default.
- W3005046878 magId "3005046878" @default.
- W3005046878 workType "article" @default.