FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005059168> ?p ?o ?g. }

• W3005059168 endingPage "158" @default.
• W3005059168 startingPage "151" @default.
• W3005059168 abstract "Excitatory amino acid transporter (EAAT)1 and EAAT2 mediate glutamatergic neurotransmission and prevent excitotoxicity through binding and transportation of glutamate into glia. These EAATs may be regulated by metabotropic glutamate receptor 5 (mGluR5), which is also expressed by glia. Whilst we have data from an Affymetrix™ Human Exon 1.0 ST Array showing higher levels of EAAT1 mRNA (+36%) in Brodmann's are (BA)9 of subjects with schizophrenia, there is evidence that EAAT1 and EAAT2, as well as mGluR5 levels, are altered in the cortex of subjects with the disorder. Hence, we measured mRNA levels of these genes in other cortical regions in subjects with that disorder. EAAT1, EAAT2 and mGluR5 mRNA were measured, in triplicate, using Quantitative PCR in BA10 and BA46 from subjects with schizophrenia (n = 20) and age and sex matched controls (n = 18). Levels of mRNA were normalised to the geometric mean of two reference genes, transcription factor B1, mitochondrial (TFB1M) and S-phase kinase-associated protein 1A (SKP1A), for which mRNA did not vary between diagnostic groups in either region. Normalised levels of EAAT1 and EAAT2 mRNA were significantly higher in BA10 (EAAT1: U = 58, p = 0.0002; EAAT2 U = 70, p = 0.0009), but not BA46 (EAAT1: U = 122, p = 0.09; EAAT2: U = 136, p = 0.21), from subjects with schizophrenia compared to controls. mGluR5 levels in BA10 (U = 173, p=0.85) and BA46 (U = 178, p = 0.96) did not vary by cohort. Our data suggests that region-specific increases in cortical EAAT1 and EAAT2 mRNA are involved in schizophrenia pathophysiology and that disrupted glutamate uptake in schizophrenia may be of particular significance in BA10." @default.
• W3005059168 created "2020-02-14" @default.
• W3005059168 creator A5010162481 @default.
• W3005059168 creator A5019481767 @default.
• W3005059168 creator A5049489837 @default.
• W3005059168 creator A5090073956 @default.
• W3005059168 date "2020-04-01" @default.
• W3005059168 modified "2023-10-16" @default.
• W3005059168 title "Excitatory amino acid transporter (EAAT)1 and EAAT2 mRNA levels are altered in the prefrontal cortex of subjects with schizophrenia" @default.
• W3005059168 cites W1549290346 @default.
• W3005059168 cites W1587874552 @default.
• W3005059168 cites W195292635 @default.
• W3005059168 cites W1964815610 @default.
• W3005059168 cites W1965459572 @default.
• W3005059168 cites W1966846060 @default.
• W3005059168 cites W1968982618 @default.
• W3005059168 cites W1969400861 @default.
• W3005059168 cites W1971043748 @default.
• W3005059168 cites W1975544222 @default.
• W3005059168 cites W1975715220 @default.
• W3005059168 cites W1979456591 @default.
• W3005059168 cites W1981912305 @default.
• W3005059168 cites W1982978658 @default.
• W3005059168 cites W1983197885 @default.
• W3005059168 cites W1986632187 @default.
• W3005059168 cites W1986782184 @default.
• W3005059168 cites W1991701465 @default.
• W3005059168 cites W1992521533 @default.
• W3005059168 cites W2000526380 @default.
• W3005059168 cites W2001402717 @default.
• W3005059168 cites W2002924208 @default.
• W3005059168 cites W2013514700 @default.
• W3005059168 cites W2014568461 @default.
• W3005059168 cites W2014816136 @default.
• W3005059168 cites W2016575029 @default.
• W3005059168 cites W2018093805 @default.
• W3005059168 cites W2018241116 @default.
• W3005059168 cites W2018283382 @default.
• W3005059168 cites W2020320000 @default.
• W3005059168 cites W2024278971 @default.
• W3005059168 cites W2029624481 @default.
• W3005059168 cites W2031647524 @default.
• W3005059168 cites W2031773723 @default.
• W3005059168 cites W2035750459 @default.
• W3005059168 cites W2036493334 @default.
• W3005059168 cites W2037927160 @default.
• W3005059168 cites W2041257397 @default.
• W3005059168 cites W2041433228 @default.
• W3005059168 cites W2044719603 @default.
• W3005059168 cites W2049157592 @default.
• W3005059168 cites W2052780535 @default.
• W3005059168 cites W2061186601 @default.
• W3005059168 cites W2073016063 @default.
• W3005059168 cites W2075689055 @default.
• W3005059168 cites W2078310394 @default.
• W3005059168 cites W2080865236 @default.
• W3005059168 cites W2085361495 @default.
• W3005059168 cites W2088134325 @default.
• W3005059168 cites W2088539367 @default.
• W3005059168 cites W2090375451 @default.
• W3005059168 cites W2090796300 @default.
• W3005059168 cites W2091306165 @default.
• W3005059168 cites W2091575312 @default.
• W3005059168 cites W2092358916 @default.
• W3005059168 cites W2093001917 @default.
• W3005059168 cites W2094046759 @default.
• W3005059168 cites W2094673798 @default.
• W3005059168 cites W2097293665 @default.
• W3005059168 cites W2100303227 @default.
• W3005059168 cites W2104288482 @default.
• W3005059168 cites W2110868914 @default.
• W3005059168 cites W2116447221 @default.
• W3005059168 cites W2119043439 @default.
• W3005059168 cites W2129244109 @default.
• W3005059168 cites W2131601310 @default.
• W3005059168 cites W2132704608 @default.
• W3005059168 cites W2138121050 @default.
• W3005059168 cites W2146324610 @default.
• W3005059168 cites W2146752498 @default.
• W3005059168 cites W2157853053 @default.
• W3005059168 cites W2158559217 @default.
• W3005059168 cites W2162098634 @default.
• W3005059168 cites W2168367599 @default.
• W3005059168 cites W2189420189 @default.
• W3005059168 cites W2195823183 @default.
• W3005059168 cites W2271177718 @default.
• W3005059168 cites W2399219594 @default.
• W3005059168 cites W2418052529 @default.
• W3005059168 cites W2547355064 @default.
• W3005059168 cites W2756061543 @default.
• W3005059168 cites W2794497080 @default.
• W3005059168 cites W2811262331 @default.
• W3005059168 cites W4210979710 @default.
• W3005059168 doi "https://doi.org/10.1016/j.jpsychires.2020.02.004" @default.
• W3005059168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32065951" @default.
• W3005059168 hasPublicationYear "2020" @default.
• W3005059168 type Work @default.
• W3005059168 sameAs 3005059168 @default.

• next