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- W3005060977 abstract "Study of interactions between the nervous system and immunity offers insights into the pathogenesis of Parkinson’s disease (PD) and potential therapeutic strategies for neurodegenerative diseases. Studies on rodents have revealed regulatory mechanisms of microglial activation and T lymphocyte recruitment in PD. However, the mechanisms underlying chronic T lymphocyte infiltration into the brain after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection into a non-human primate (NHP) model of PD remain unknown. This study aimed to investigate changes in serum RANTES (regulated on activation, normal T cell expression and secretion) and analyze the chronic infiltration of T lymphocytes into the brain and microglia activation in NHPs at 48 weeks post-MPTP administration. We found selective and local chronic infiltration of CD4+ and CD8+ T lymphocytes, loss of dopaminergic neurons, dopamine transporter expression, chronic normalization of RANTES in the peripheral blood, and altered microglial morphology at 48 weeks after MPTP injection. This study confirms the involvement of CD4+ and CD8+ T lymphocyte infiltration in MPTP-induced NHP models of PD. Additionally, we corroborated previous findings regarding the mechanisms of T lymphocyte-induced neurodegeneration. The findings of chronic infiltration of T lymphocytes in our NHP model of PD provide novel insights into PD pathogenesis and the development of preventive and therapeutic agents." @default.
- W3005060977 created "2020-02-14" @default.
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- W3005060977 date "2020-04-01" @default.
- W3005060977 modified "2023-10-17" @default.
- W3005060977 title "Chronic Infiltration of T Lymphocytes into the Brain in a Non-human Primate Model of Parkinson’s Disease" @default.
- W3005060977 cites W1535485604 @default.
- W3005060977 cites W1540142856 @default.
- W3005060977 cites W1546232808 @default.
- W3005060977 cites W1810017474 @default.
- W3005060977 cites W1876850155 @default.
- W3005060977 cites W1971171795 @default.
- W3005060977 cites W1971408164 @default.
- W3005060977 cites W1982207977 @default.
- W3005060977 cites W1994102729 @default.
- W3005060977 cites W1995757841 @default.
- W3005060977 cites W1998310721 @default.
- W3005060977 cites W2012511957 @default.
- W3005060977 cites W2014182955 @default.
- W3005060977 cites W2015192366 @default.
- W3005060977 cites W2016986803 @default.
- W3005060977 cites W2018460396 @default.
- W3005060977 cites W2025032336 @default.
- W3005060977 cites W2025116212 @default.
- W3005060977 cites W2033231119 @default.
- W3005060977 cites W2035200180 @default.
- W3005060977 cites W2039314170 @default.
- W3005060977 cites W2040937292 @default.
- W3005060977 cites W2041158634 @default.
- W3005060977 cites W2043069334 @default.
- W3005060977 cites W2061891340 @default.
- W3005060977 cites W2067018636 @default.
- W3005060977 cites W2071119968 @default.
- W3005060977 cites W2072942101 @default.
- W3005060977 cites W2074869406 @default.
- W3005060977 cites W2075856383 @default.
- W3005060977 cites W2076989093 @default.
- W3005060977 cites W2078020097 @default.
- W3005060977 cites W2080224067 @default.
- W3005060977 cites W2082678422 @default.
- W3005060977 cites W2101243397 @default.
- W3005060977 cites W2114395128 @default.
- W3005060977 cites W2131694758 @default.
- W3005060977 cites W2138900023 @default.
- W3005060977 cites W2139084347 @default.
- W3005060977 cites W2155737332 @default.
- W3005060977 cites W2161911105 @default.
- W3005060977 cites W2258002535 @default.
- W3005060977 cites W2261157573 @default.
- W3005060977 cites W2376240640 @default.
- W3005060977 cites W2494229447 @default.
- W3005060977 cites W2515648649 @default.
- W3005060977 cites W2521327412 @default.
- W3005060977 cites W2556865414 @default.
- W3005060977 cites W2585996473 @default.
- W3005060977 cites W2595858818 @default.
- W3005060977 cites W2608017363 @default.
- W3005060977 cites W2611573935 @default.
- W3005060977 cites W2638382976 @default.
- W3005060977 cites W2767236431 @default.
- W3005060977 cites W2773427194 @default.
- W3005060977 cites W2793495810 @default.
- W3005060977 cites W2868920275 @default.
- W3005060977 cites W2887509324 @default.
- W3005060977 cites W2889106553 @default.
- W3005060977 cites W2898325560 @default.
- W3005060977 cites W2899188579 @default.
- W3005060977 cites W2903888966 @default.
- W3005060977 cites W2911851957 @default.
- W3005060977 cites W2971622831 @default.
- W3005060977 cites W2982590191 @default.
- W3005060977 cites W4211044101 @default.
- W3005060977 cites W4211123396 @default.
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- W3005060977 doi "https://doi.org/10.1016/j.neuroscience.2020.01.043" @default.
- W3005060977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32036014" @default.
- W3005060977 hasPublicationYear "2020" @default.