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- W3005082502 abstract "• This search aimed to find dietary conditions enhancing endogenous equol production. • Control and experimental diets with isoflavones were run in an artificial intestine. • The model was inoculated with a pooled faecal homogenate from equol-producing women. • A carbohydrate-rich diet was found to favour the synthesis of equol. In order to find dietary conditions favouring endogenous equol biosynthesis, a pooled faecal homogenate from equol-producing women was used to inoculate the TIM-2 artificial model of the human proximal colon. The model was fuelled with control diets not supplemented (C) or supplemented (C-ISO) with isoflavones, and two isoflavone-containing diets rich in carbohydrate (CH-ISO) or protein (PR-ISO). Compared to the C-ISO control, the CH-ISO diet doubled the production of equol, while with the PR-ISO diet the production of equol in cultures decreased sharply. The CH-ISO diet was also associated with enhanced butyrate production. The numbers of most bacterial populations analysed did not significantly change along cultures with any of the diets. Surprisingly, counts for a gene involved in equol production ( tdr ) were reduced in all cultures, reflecting a reduction in the number of equol-producing bacteria . In conclusion, under the TIM-2 culture conditions established, the CH-ISO diet favoured the synthesis of equol." @default.
- W3005082502 created "2020-02-14" @default.
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- W3005082502 date "2020-03-01" @default.
- W3005082502 modified "2023-09-29" @default.
- W3005082502 title "Modulation of equol production via different dietary regimens in an artificial model of the human colon" @default.
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- W3005082502 doi "https://doi.org/10.1016/j.jff.2020.103819" @default.
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