FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005097055> ?p ?o ?g. }

• W3005097055 endingPage "485" @default.
• W3005097055 startingPage "475" @default.
• W3005097055 abstract "The demineralized bone matrix (DBM) is the most widely used bone allograft, which is obtained by removing the mineral component of bone, leading to exposure of the proteins responsible for osteoinduction. For clinical use, DBM shall be formulated with a carrier that provides consistency and improves its osteoinduction. In this study, three DBM formulations with glycerol (Gly), hyaluronic acid (HA), and gelatin methacryloyl (GelMA) were evaluated measuring their physicochemical properties (microstructure, compressive strength, and serum cohesivity) and their osteoinductive capacity both in vitro using C2C12 cells and umbilical cord human mesenchymal stem cells and in vivo in an ectopic bone formation model in athymic mice. To assess the effectiveness of DBM in vitro in inducing the differentiation into osteoblasts, alkaline phosphatase (ALP) activity was assessed in combination with a cytotoxicity assay. In vivo, new bone formation was assessed by histological and radiological analysis. In the compression and in the serum cohesive assays, the GelMA DBM formulation showed its superiority over the other formulations. In addition, GelMA showed a more compact structure analysed by scanning electron microscopy. Higher cell toxicity was observed on Gly formulations in vitro, whereas GelMa and HA showed very low toxicity. All formulations significantly improved ALP activity compared with control. In the in vivo studies, GelMA showed the greatest osteoinductive potential with a higher percentage of new bone and bone marrow formation. Our results suggest GelMA is useful as a carrier for DBM designed to promote the formation of the new bone." @default.
• W3005097055 created "2020-02-14" @default.
• W3005097055 creator A5017198028 @default.
• W3005097055 creator A5042695841 @default.
• W3005097055 creator A5049984754 @default.
• W3005097055 creator A5052205520 @default.
• W3005097055 creator A5057108279 @default.
• W3005097055 creator A5062895945 @default.
• W3005097055 creator A5068078399 @default.
• W3005097055 creator A5076027636 @default.
• W3005097055 date "2020-03-01" @default.
• W3005097055 modified "2023-10-17" @default.
• W3005097055 title "Improved physical and osteoinductive properties of demineralized bone matrix by gelatin methacryloyl formulation" @default.
• W3005097055 cites W107463359 @default.
• W3005097055 cites W1120477740 @default.
• W3005097055 cites W1560201504 @default.
• W3005097055 cites W1968822620 @default.
• W3005097055 cites W1969475486 @default.
• W3005097055 cites W1973362530 @default.
• W3005097055 cites W1980875076 @default.
• W3005097055 cites W1982413446 @default.
• W3005097055 cites W1986138379 @default.
• W3005097055 cites W1988149634 @default.
• W3005097055 cites W1994034314 @default.
• W3005097055 cites W2005165835 @default.
• W3005097055 cites W2014624625 @default.
• W3005097055 cites W2016859011 @default.
• W3005097055 cites W2029672509 @default.
• W3005097055 cites W2030585596 @default.
• W3005097055 cites W2039907949 @default.
• W3005097055 cites W2042474003 @default.
• W3005097055 cites W2045532617 @default.
• W3005097055 cites W2047134067 @default.
• W3005097055 cites W2050507929 @default.
• W3005097055 cites W2052318709 @default.
• W3005097055 cites W2092742402 @default.
• W3005097055 cites W2092914918 @default.
• W3005097055 cites W2113173016 @default.
• W3005097055 cites W2117566184 @default.
• W3005097055 cites W2132562569 @default.
• W3005097055 cites W2145319120 @default.
• W3005097055 cites W2159704089 @default.
• W3005097055 cites W2265369649 @default.
• W3005097055 cites W2409523254 @default.
• W3005097055 cites W2427397585 @default.
• W3005097055 cites W2536413732 @default.
• W3005097055 cites W2623981860 @default.
• W3005097055 cites W2810319230 @default.
• W3005097055 doi "https://doi.org/10.1002/term.3012" @default.
• W3005097055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32011080" @default.
• W3005097055 hasPublicationYear "2020" @default.
• W3005097055 type Work @default.
• W3005097055 sameAs 3005097055 @default.
• W3005097055 citedByCount "5" @default.
• W3005097055 countsByYear W30050970552021 @default.
• W3005097055 countsByYear W30050970552022 @default.
• W3005097055 countsByYear W30050970552023 @default.
• W3005097055 crossrefType "journal-article" @default.
• W3005097055 hasAuthorship W3005097055A5017198028 @default.
• W3005097055 hasAuthorship W3005097055A5042695841 @default.
• W3005097055 hasAuthorship W3005097055A5049984754 @default.
• W3005097055 hasAuthorship W3005097055A5052205520 @default.
• W3005097055 hasAuthorship W3005097055A5057108279 @default.
• W3005097055 hasAuthorship W3005097055A5062895945 @default.
• W3005097055 hasAuthorship W3005097055A5068078399 @default.
• W3005097055 hasAuthorship W3005097055A5076027636 @default.
• W3005097055 hasBestOaLocation W30050970551 @default.
• W3005097055 hasConcept C105702510 @default.
• W3005097055 hasConcept C106487976 @default.
• W3005097055 hasConcept C136229726 @default.
• W3005097055 hasConcept C150903083 @default.
• W3005097055 hasConcept C160160445 @default.
• W3005097055 hasConcept C181199279 @default.
• W3005097055 hasConcept C185592680 @default.
• W3005097055 hasConcept C192562407 @default.
• W3005097055 hasConcept C194257627 @default.
• W3005097055 hasConcept C198826908 @default.
• W3005097055 hasConcept C202751555 @default.
• W3005097055 hasConcept C203014093 @default.
• W3005097055 hasConcept C207001950 @default.
• W3005097055 hasConcept C2777529286 @default.
• W3005097055 hasConcept C2778823387 @default.
• W3005097055 hasConcept C2779869580 @default.
• W3005097055 hasConcept C2780007613 @default.
• W3005097055 hasConcept C2780783641 @default.
• W3005097055 hasConcept C30352789 @default.
• W3005097055 hasConcept C35496256 @default.
• W3005097055 hasConcept C43617362 @default.
• W3005097055 hasConcept C46362747 @default.
• W3005097055 hasConcept C49040817 @default.
• W3005097055 hasConcept C55493867 @default.
• W3005097055 hasConcept C71924100 @default.
• W3005097055 hasConcept C86803240 @default.
• W3005097055 hasConcept C94105702 @default.
• W3005097055 hasConcept C95444343 @default.
• W3005097055 hasConceptScore W3005097055C105702510 @default.
• W3005097055 hasConceptScore W3005097055C106487976 @default.
• W3005097055 hasConceptScore W3005097055C136229726 @default.

• next