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• W3005113480 abstract "The ability to integrate biological signals and execute a functional response when appropriate is critical for sophisticated cell engineering using synthetic biology. Although the CRISPR-Cas system has been harnessed for synthetic manipulation of the genome, it has not been fully utilized for complex environmental signal sensing, integration, and actuation. Here, we develop a split dCas12a platform and show that it allows for the construction of multi-input, multi-output logic circuits in mammalian cells. The system is highly programmable and can generate expandable AND gates with two, three, and four inputs. It can also incorporate NOT logic by using anti-CRISPR proteins as an OFF switch. By coupling the split dCas12a design to multiple tumor-relevant promoters, we provide a proof of concept that the system can implement logic gating to specifically detect breast cancer cells and execute therapeutic immunomodulatory responses." @default.
• W3005113480 created "2020-02-14" @default.
• W3005113480 creator A5017305667 @default.
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• W3005113480 date "2020-04-01" @default.
• W3005113480 modified "2023-10-15" @default.
• W3005113480 title "Multiple Input Sensing and Signal Integration Using a Split Cas12a System" @default.
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• W3005113480 doi "https://doi.org/10.1016/j.molcel.2020.01.016" @default.
• W3005113480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32027839" @default.
• W3005113480 hasPublicationYear "2020" @default.
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