Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005138698> ?p ?o ?g. }
- W3005138698 abstract "Abstract The phytohormone cytokinin influences many aspects of plant growth and development, several of which also involve the cellular process of autophagy, including leaf senescence, nutrient re-mobilization, and developmental transitions. The Arabidopsis type-A Response Regulators (type-A ARR) are negative regulators of cytokinin signaling that are transcriptionally induced in response to cytokinin. Here, we describe a mechanistic link between cytokinin signaling and autophagy, demonstrating that plants modulate cytokinin sensitivity through autophagic regulation of type-A ARR proteins. Type-A ARR proteins were degraded by autophagy in an AUTOPHAGY-RELATED (ATG)5-dependent manner. EXO70D family members interacted with Type-A ARR proteins, likely in a phosphorylation-dependent manner, and recruited them to autophagosomes via interaction with the core autophagy protein, ATG8. Consistently, loss-of-function exo70D1,2,3 mutants compromised targeting of type-A ARRs to autophagic vesicles, have elevated levels of type-A ARR proteins, and are hyposensitive to cytokinin. Disruption of both type-A ARRs and EXO70D1,2,3 compromised survival in carbon-deficient conditions, suggesting interaction between autophagy and cytokinin responsiveness in response to stress. These results indicate that the EXO70D proteins act as selective autophagy receptors to target type-A ARR cargos for autophagic degradation, demonstrating that cytokinin signaling can be modulated by selective autophagy." @default.
- W3005138698 created "2020-02-14" @default.
- W3005138698 creator A5015661318 @default.
- W3005138698 creator A5032306470 @default.
- W3005138698 creator A5033574231 @default.
- W3005138698 creator A5048799981 @default.
- W3005138698 creator A5075404623 @default.
- W3005138698 creator A5076550421 @default.
- W3005138698 date "2020-02-07" @default.
- W3005138698 modified "2023-09-26" @default.
- W3005138698 title "EXO70D isoforms mediate selective autophagic degradation of Type-A ARR proteins to regulate cytokinin sensitivity" @default.
- W3005138698 cites W1526993239 @default.
- W3005138698 cites W1965477145 @default.
- W3005138698 cites W1974371221 @default.
- W3005138698 cites W1978554067 @default.
- W3005138698 cites W1979765374 @default.
- W3005138698 cites W1982732854 @default.
- W3005138698 cites W1989039494 @default.
- W3005138698 cites W1992591998 @default.
- W3005138698 cites W1993530554 @default.
- W3005138698 cites W1996686613 @default.
- W3005138698 cites W1996761427 @default.
- W3005138698 cites W1998141700 @default.
- W3005138698 cites W2003810707 @default.
- W3005138698 cites W2005124332 @default.
- W3005138698 cites W2006176190 @default.
- W3005138698 cites W2006264750 @default.
- W3005138698 cites W2011580247 @default.
- W3005138698 cites W2020350137 @default.
- W3005138698 cites W2022050193 @default.
- W3005138698 cites W2023992819 @default.
- W3005138698 cites W2024556021 @default.
- W3005138698 cites W2026068388 @default.
- W3005138698 cites W2026753135 @default.
- W3005138698 cites W2029558360 @default.
- W3005138698 cites W2035284951 @default.
- W3005138698 cites W2045139191 @default.
- W3005138698 cites W2045981379 @default.
- W3005138698 cites W2047815190 @default.
- W3005138698 cites W2062893362 @default.
- W3005138698 cites W2070826641 @default.
- W3005138698 cites W2072057016 @default.
- W3005138698 cites W2077757969 @default.
- W3005138698 cites W2077919955 @default.
- W3005138698 cites W2078745435 @default.
- W3005138698 cites W2079622659 @default.
- W3005138698 cites W2087867538 @default.
- W3005138698 cites W2088410574 @default.
- W3005138698 cites W2090025002 @default.
- W3005138698 cites W2094989185 @default.
- W3005138698 cites W2096137680 @default.
- W3005138698 cites W2096195756 @default.
- W3005138698 cites W2096370645 @default.
- W3005138698 cites W2099943418 @default.
- W3005138698 cites W2103003322 @default.
- W3005138698 cites W2104314673 @default.
- W3005138698 cites W2104989176 @default.
- W3005138698 cites W2108244474 @default.
- W3005138698 cites W2115246339 @default.
- W3005138698 cites W2115734610 @default.
- W3005138698 cites W2116122104 @default.
- W3005138698 cites W2117801718 @default.
- W3005138698 cites W2119778922 @default.
- W3005138698 cites W2124972828 @default.
- W3005138698 cites W2125332907 @default.
- W3005138698 cites W2125782175 @default.
- W3005138698 cites W2130307437 @default.
- W3005138698 cites W2130909933 @default.
- W3005138698 cites W2132792723 @default.
- W3005138698 cites W2137657884 @default.
- W3005138698 cites W2138445265 @default.
- W3005138698 cites W2139418216 @default.
- W3005138698 cites W2141429272 @default.
- W3005138698 cites W2144362290 @default.
- W3005138698 cites W2146059247 @default.
- W3005138698 cites W2151817435 @default.
- W3005138698 cites W2152389843 @default.
- W3005138698 cites W2155227945 @default.
- W3005138698 cites W2158215557 @default.
- W3005138698 cites W2160586137 @default.
- W3005138698 cites W2162505470 @default.
- W3005138698 cites W2167279371 @default.
- W3005138698 cites W2418899861 @default.
- W3005138698 cites W2522450723 @default.
- W3005138698 cites W2604101843 @default.
- W3005138698 cites W2606510453 @default.
- W3005138698 cites W2608723263 @default.
- W3005138698 cites W2611401896 @default.
- W3005138698 cites W2614333682 @default.
- W3005138698 cites W2737978347 @default.
- W3005138698 cites W2738969775 @default.
- W3005138698 cites W2752875427 @default.
- W3005138698 cites W2754146743 @default.
- W3005138698 cites W2766496749 @default.
- W3005138698 cites W2789450022 @default.
- W3005138698 cites W2790545864 @default.
- W3005138698 cites W2796159186 @default.
- W3005138698 cites W2804284378 @default.
- W3005138698 cites W2915908517 @default.
- W3005138698 cites W2949924475 @default.