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• W3005192783 endingPage "272" @default.
• W3005192783 startingPage "264" @default.
• W3005192783 abstract "Ovarian tissue cryopreservation is emerging as a promising alternative for fertility preservation of cancer survivors. To date, more than a hundred couples have successfully had babies using this procedure, although it is still considered experimental and demands further investigation. In this work, we evaluated the effects of vitrification, warming and autotransplantation procedures on the morphology and gene expression of murine ovaries. Ovaries were removed from adult female C57BL6 mice (n = 15), vitrified, warmed and autotransplanted (vitrified group), additionally, ovaries were autotransplanted without vitrification (control group, n = 15). After twenty days, grafted ovaries were harvested and used for histological and ultrastructural analysis, germinal vesicle (GV) oocyte collection, RNA sequencing, and Transmission Electron Microscopy (TEM). All classes of follicles and GV were observed in both control and vitrified/warmed transplanted ovaries, and the numbers of primordial, antral and atretic follicles were not different (p > 0.05). Using RNA-seq, we detected 16,602 vs 13,527 expressed genes in vitrified and control ovaries, respectively; and 623 significantly dysregulated genes (fold change >1.5; 332 up-regulated and 291 down-regulated). Cellular membranes, cytoskeletons, and extracellular matrices were found as the main functions of the differentially expressed genes. Moreover, vitrified samples also presented ultrastructural alterations in the cytoskeleton, cell junctions, and endoplasmic reticulum. Taken together, this work showed for the first time that ovarian cells might trigger a compensatory gene regulation mechanism to maintain cellular structure and folliculogenesis progression after vitrification and autotransplantation." @default.
• W3005192783 created "2020-02-14" @default.
• W3005192783 creator A5015913210 @default.
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• W3005192783 date "2020-06-01" @default.
• W3005192783 modified "2023-10-16" @default.
• W3005192783 title "Vitrification leads to transcriptomic modifications of mice ovaries that do not affect folliculogenesis progression" @default.
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• W3005192783 doi "https://doi.org/10.1016/j.repbio.2020.02.001" @default.
• W3005192783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32044207" @default.
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