Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005199415> ?p ?o ?g. }
- W3005199415 abstract "Cronobacter spp. can cause systemic infections in immunocompromised patients, especially neonatal meningitis, sepsis, and necrotizing enterocolitis in neonates. Although some virulence factors have been reported previously, the pathogenesis of Cronobacter remains unclear. In this study, we compared genome sequences of Cronobacter from different species, sequence types, and sources, with the virulence genes in the virulence factor database (VFDB). The results showed that Cronobacter has species-specificity for these virulence genes. Besides this, the two gene clusters, including sfp encoding fimbriae and hly encoding hemolysin, were discovered. Through cell adhesion, cytotoxicity, and hemolysis assay, we found the isolates possessed the two gene clusters, had higher cytotoxicity and stronger hemolysis capacity than other isolates in this study. In addition, Type VI secretion system (T6SS) cluster and putative fimbria gene clusters of Cronobacter were analyzed, and T6SS have species-specificity, and that isolates with high cytotoxicity possessed more complete T6SS cluster construction than the rest. It demonstrated the two novel gene clusters and T6SS cluster were involved in the mechanism underlying the cytotoxicity of Cronobacter." @default.
- W3005199415 created "2020-02-14" @default.
- W3005199415 creator A5006313457 @default.
- W3005199415 creator A5012851930 @default.
- W3005199415 creator A5014035111 @default.
- W3005199415 creator A5020535873 @default.
- W3005199415 creator A5037331723 @default.
- W3005199415 creator A5042968243 @default.
- W3005199415 creator A5067025732 @default.
- W3005199415 creator A5070127894 @default.
- W3005199415 creator A5089438227 @default.
- W3005199415 date "2020-02-07" @default.
- W3005199415 modified "2023-09-27" @default.
- W3005199415 title "Genomic Analysis of Putative Virulence Factors Affecting Cytotoxicity of Cronobacter" @default.
- W3005199415 cites W132361757 @default.
- W3005199415 cites W1666952362 @default.
- W3005199415 cites W1970035873 @default.
- W3005199415 cites W1973516496 @default.
- W3005199415 cites W1974817747 @default.
- W3005199415 cites W1979209211 @default.
- W3005199415 cites W1996913826 @default.
- W3005199415 cites W1997941860 @default.
- W3005199415 cites W2025607602 @default.
- W3005199415 cites W2033163188 @default.
- W3005199415 cites W2039985444 @default.
- W3005199415 cites W2089208116 @default.
- W3005199415 cites W2101419106 @default.
- W3005199415 cites W2139747853 @default.
- W3005199415 cites W2142518288 @default.
- W3005199415 cites W2143358910 @default.
- W3005199415 cites W2156801648 @default.
- W3005199415 cites W2161546116 @default.
- W3005199415 cites W2163455067 @default.
- W3005199415 cites W2330884580 @default.
- W3005199415 cites W2460540891 @default.
- W3005199415 cites W2556690262 @default.
- W3005199415 cites W2582033886 @default.
- W3005199415 cites W2582942533 @default.
- W3005199415 cites W2593018935 @default.
- W3005199415 cites W2749424030 @default.
- W3005199415 cites W2765449164 @default.
- W3005199415 cites W2783696850 @default.
- W3005199415 cites W2790542614 @default.
- W3005199415 cites W2888829604 @default.
- W3005199415 cites W2889668878 @default.
- W3005199415 cites W2892946540 @default.
- W3005199415 cites W2896077402 @default.
- W3005199415 cites W2947777897 @default.
- W3005199415 doi "https://doi.org/10.3389/fmicb.2019.03104" @default.
- W3005199415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7019382" @default.
- W3005199415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32117082" @default.
- W3005199415 hasPublicationYear "2020" @default.
- W3005199415 type Work @default.
- W3005199415 sameAs 3005199415 @default.
- W3005199415 citedByCount "8" @default.
- W3005199415 countsByYear W30051994152021 @default.
- W3005199415 countsByYear W30051994152022 @default.
- W3005199415 countsByYear W30051994152023 @default.
- W3005199415 crossrefType "journal-article" @default.
- W3005199415 hasAuthorship W3005199415A5006313457 @default.
- W3005199415 hasAuthorship W3005199415A5012851930 @default.
- W3005199415 hasAuthorship W3005199415A5014035111 @default.
- W3005199415 hasAuthorship W3005199415A5020535873 @default.
- W3005199415 hasAuthorship W3005199415A5037331723 @default.
- W3005199415 hasAuthorship W3005199415A5042968243 @default.
- W3005199415 hasAuthorship W3005199415A5067025732 @default.
- W3005199415 hasAuthorship W3005199415A5070127894 @default.
- W3005199415 hasAuthorship W3005199415A5089438227 @default.
- W3005199415 hasBestOaLocation W30051994151 @default.
- W3005199415 hasConcept C104317684 @default.
- W3005199415 hasConcept C203014093 @default.
- W3005199415 hasConcept C2776307328 @default.
- W3005199415 hasConcept C2777771644 @default.
- W3005199415 hasConcept C2778004101 @default.
- W3005199415 hasConcept C2778827730 @default.
- W3005199415 hasConcept C2779902561 @default.
- W3005199415 hasConcept C2781090273 @default.
- W3005199415 hasConcept C36857842 @default.
- W3005199415 hasConcept C39103817 @default.
- W3005199415 hasConcept C523546767 @default.
- W3005199415 hasConcept C54355233 @default.
- W3005199415 hasConcept C55493867 @default.
- W3005199415 hasConcept C60987743 @default.
- W3005199415 hasConcept C86803240 @default.
- W3005199415 hasConcept C89423630 @default.
- W3005199415 hasConceptScore W3005199415C104317684 @default.
- W3005199415 hasConceptScore W3005199415C203014093 @default.
- W3005199415 hasConceptScore W3005199415C2776307328 @default.
- W3005199415 hasConceptScore W3005199415C2777771644 @default.
- W3005199415 hasConceptScore W3005199415C2778004101 @default.
- W3005199415 hasConceptScore W3005199415C2778827730 @default.
- W3005199415 hasConceptScore W3005199415C2779902561 @default.
- W3005199415 hasConceptScore W3005199415C2781090273 @default.
- W3005199415 hasConceptScore W3005199415C36857842 @default.
- W3005199415 hasConceptScore W3005199415C39103817 @default.
- W3005199415 hasConceptScore W3005199415C523546767 @default.
- W3005199415 hasConceptScore W3005199415C54355233 @default.
- W3005199415 hasConceptScore W3005199415C55493867 @default.
- W3005199415 hasConceptScore W3005199415C60987743 @default.
- W3005199415 hasConceptScore W3005199415C86803240 @default.