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• W3005200766 endingPage "1928" @default.
• W3005200766 startingPage "1908" @default.
• W3005200766 abstract "After the first seed concept introduced in the 18th century, different disciplines have attributed different names to dual-functional molecules depending on their application, including bioconjugates, bifunctional compounds, multitargeting molecules, chimeras, hybrids, engineered compounds. However, these engineered constructs share a general structure: a first component that targets a specific cell and a second component that exerts the pharmacological activity. A stable or cleavable linker connects the two modules of a chimera. Herein, we discuss the recent advances in the rapidly expanding field of chimeric molecules leveraging chemical biology concepts. This Perspective is focused on bifunctional compounds in which one component is a lead compound or a drug. In detail, we discuss chemical features of chimeric molecules and their use for targeted delivery and for target engagement studies." @default.
• W3005200766 created "2020-02-14" @default.
• W3005200766 creator A5002744395 @default.
• W3005200766 creator A5023317651 @default.
• W3005200766 creator A5035521326 @default.
• W3005200766 creator A5067042371 @default.
• W3005200766 date "2020-02-05" @default.
• W3005200766 modified "2023-10-18" @default.
• W3005200766 title "Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology" @default.
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