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- W3005211060 abstract "To examine the effects of perioperative intravenous administration of flurbiprofen axetil (FA) on pain associated with transrectal ultrasound-guided prostate biopsy.This was a randomized,controlled study. Eighty-one patients who underwent 12 core prostate biopsy were included in the study. The patients were randomly assigned to one of three groups (n=27 in each) by type of procedure during prostate biopsy. Group intrarectal local anesthesia (IRLA) received intrarectal 5% (0.05 g/L) lidocaine gel 60 mg, 5 minutes before the procedure alone; Group FA received intravenous flurbiprofen axetil (1 mg/kg) 1 hour before the procedure; Group IRLA+FA received intrarectal 5% lidocaine gel 60 mg, 5 minutes before the procedure and intravenous flurbiprofen axetil (1 mg/kg) 1 hour before the procedure. The patients were asked to score the pain by using visual analogue scale (VAS) in 4 situations,including when the probe was inserted (VASI),during anesthesia (VAS II),during biopsy (VAS III) and 20 minutes after biopsy (VAS IV). The findings were evaluated with analysis of variance,and the Tukey post hoc test was followed with an overall 2-tailed significance level at α =0.05. P1, P value between Group IRLA and Group FA; P2, P value between Group FA and Group IRLA +FA, P3, P value between Group IRLA and Group IRLA +FA. The bonferroni method was used to adjust the test level, α=0.017,a P value of less than 0.017 was accepted as the threshold for statistical significance.No major complications,including sepsis and severe rectal bleeding,were noted in any patient. There were no differences in general condition of the patients before procedure among the 3 groups. There were statistically significant differences in VAS scores among the 3 groups in VAS II (5.7±2.2, 3.0±1.5,3.3±1.9,respectively,P=0.012) and VAS III (6.7±2.3,3.0±2.1,2.9±1.6,respectively,P=0.001). There were no differences in the pain scores among the 3 groups during probe insertion (VAS I, 3.2±1.0,4.1±2.1,4.2±1.7, respectively,P=5.752) and 20 minutes after biopsy (VAS IV, 1.4±2.1,1.0±0.9,1.1±0.7,respectively,P=3.772). Between-column differences among the 3 groups were VAS II (P1=0.007,P2=5.655,P3=0.001,respectively) and VAS III(P1=0.008,P2=7.517,P3=0.001,respectively),the differences between Group IRLA and Group FA,Group IRLA and Group IRLA +FA in VAS II and VAS III were statistically significant.The intravenous flurbiprofen axetil was found to be more effective than intrarectal lidocaine gel alone." @default.
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- W3005211060 date "2017-08-18" @default.
- W3005211060 modified "2023-09-23" @default.
- W3005211060 title "[Application of flurbiprofen axetil in pain management associated during transrectal ultrasound-guided prostate biopsy]." @default.
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