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- W3005222016 abstract "Monocytes (Mos) are immune cells that critically regulate cancer, enabling tumor growth and modulating metastasis. Mos can give rise to tumor-associated macrophages (TAMs) and Mo-derived dendritic cells (moDCs), all of which shape the tumor microenvironment (TME). Thus, understanding their roles in the TME is key for improved immunotherapy. Concurrently, various biological and mechanical factors including changes in local cytokines, extracellular matrix production, and metabolic changes in the TME affect the roles of monocytic cells. As such, relevant TME models are critical to achieve meaningful insight on the precise functions, mechanisms, and effects of monocytic cells. Notably, murine models have yielded significant insight into human Mo biology. However, many of these results have yet to be confirmed in humans, reinforcing the need for improved in vitro human TME models for the development of cancer interventions. Thus, this chapter (1) summarizes current insight on the tumor biology of Mos, TAMs, and moDCs, (2) highlights key therapeutic applications relevant to these cells, and (3) discusses various TME models to study their TME-related activity. We conclude with a perspective on the future research trajectory of this topic." @default.
- W3005222016 created "2020-02-14" @default.
- W3005222016 creator A5047618524 @default.
- W3005222016 creator A5050775309 @default.
- W3005222016 creator A5080670471 @default.
- W3005222016 creator A5091486825 @default.
- W3005222016 date "2020-01-01" @default.
- W3005222016 modified "2023-09-24" @default.
- W3005222016 title "Models for Monocytic Cells in the Tumor Microenvironment" @default.
- W3005222016 cites W1557119871 @default.
- W3005222016 cites W1563631631 @default.
- W3005222016 cites W1669428397 @default.
- W3005222016 cites W1689372518 @default.
- W3005222016 cites W1800099715 @default.
- W3005222016 cites W1815665069 @default.
- W3005222016 cites W1829321784 @default.
- W3005222016 cites W1925042157 @default.
- W3005222016 cites W1931807888 @default.
- W3005222016 cites W1940048983 @default.
- W3005222016 cites W1955758659 @default.
- W3005222016 cites W1956258286 @default.
- W3005222016 cites W1963904011 @default.
- W3005222016 cites W1964082285 @default.
- W3005222016 cites W1964596167 @default.
- W3005222016 cites W1965859404 @default.
- W3005222016 cites W1966100182 @default.
- W3005222016 cites W1966217032 @default.
- W3005222016 cites W1966664680 @default.
- W3005222016 cites W1968008559 @default.
- W3005222016 cites W1969057487 @default.
- W3005222016 cites W1969174874 @default.
- W3005222016 cites W1969607893 @default.
- W3005222016 cites W1971620413 @default.
- W3005222016 cites W1971641390 @default.
- W3005222016 cites W1971801942 @default.
- W3005222016 cites W1973759139 @default.
- W3005222016 cites W1976199086 @default.
- W3005222016 cites W1978496495 @default.
- W3005222016 cites W1982447134 @default.
- W3005222016 cites W1982488143 @default.
- W3005222016 cites W1983676906 @default.
- W3005222016 cites W1984242958 @default.
- W3005222016 cites W1984366825 @default.
- W3005222016 cites W1984378291 @default.
- W3005222016 cites W1986224320 @default.
- W3005222016 cites W1986587470 @default.
- W3005222016 cites W1987313116 @default.
- W3005222016 cites W1989126519 @default.
- W3005222016 cites W1990083653 @default.
- W3005222016 cites W1993603859 @default.
- W3005222016 cites W1995232616 @default.
- W3005222016 cites W1997944395 @default.
- W3005222016 cites W2000217512 @default.
- W3005222016 cites W2001752971 @default.
- W3005222016 cites W2002300721 @default.
- W3005222016 cites W2003500892 @default.
- W3005222016 cites W2004014796 @default.
- W3005222016 cites W2004150448 @default.
- W3005222016 cites W2006908114 @default.
- W3005222016 cites W2007723697 @default.
- W3005222016 cites W2008616663 @default.
- W3005222016 cites W2011615632 @default.
- W3005222016 cites W2012638073 @default.
- W3005222016 cites W2015141049 @default.
- W3005222016 cites W2016733583 @default.
- W3005222016 cites W2017465156 @default.
- W3005222016 cites W2018372624 @default.
- W3005222016 cites W2020074441 @default.
- W3005222016 cites W2022192518 @default.
- W3005222016 cites W2026548544 @default.
- W3005222016 cites W2026578487 @default.
- W3005222016 cites W2028433016 @default.
- W3005222016 cites W2029726426 @default.
- W3005222016 cites W2031856001 @default.
- W3005222016 cites W2032229065 @default.
- W3005222016 cites W2033278321 @default.
- W3005222016 cites W2033474014 @default.
- W3005222016 cites W2033820276 @default.
- W3005222016 cites W2034927361 @default.
- W3005222016 cites W2035213168 @default.
- W3005222016 cites W2036564362 @default.
- W3005222016 cites W2036959910 @default.
- W3005222016 cites W2037489902 @default.
- W3005222016 cites W2038316782 @default.
- W3005222016 cites W2040695321 @default.
- W3005222016 cites W2041663579 @default.
- W3005222016 cites W2043044540 @default.
- W3005222016 cites W2043991982 @default.
- W3005222016 cites W2045301027 @default.
- W3005222016 cites W2047209914 @default.
- W3005222016 cites W2048204452 @default.
- W3005222016 cites W2049528074 @default.
- W3005222016 cites W2051139585 @default.
- W3005222016 cites W2051455650 @default.
- W3005222016 cites W2053466472 @default.
- W3005222016 cites W2054472394 @default.
- W3005222016 cites W2055348159 @default.
- W3005222016 cites W2057993158 @default.