FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005229147> ?p ?o ?g. }

• W3005229147 endingPage "699" @default.
• W3005229147 startingPage "690" @default.
• W3005229147 abstract "The aim of this study was to identify genes with clinical significance in colorectal cancer (CRC). Gene expression profiles of 585 CRC tissues and 61 normal colorectal tissues from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were used to identify differentially expressed genes (DEGs) between CRC and normal colorectal tissues. DAVID and KOBAS tools were used to explore Gene Ontology (GO) and KEGG pathways enriched by DEGs, respectively. In addition, TCGA data sets were also used to identify prognostic factors and develop a prognostic prediction model for CRC. A total of 353 DEGs including 117 upregulated and 236 downregulated genes in CRC were identified based on GSE32323 data set. These DEGs were significantly enriched in the biological process related to the regulation of cell proliferation and 50 signaling pathways, such as “TGF-beta signaling pathway,” “Wnt signaling pathway,” and “Jak-STAT signaling pathway.” GCG, ADH1B, SLC4A4, ZG16, and CLCA4 were the top five downregulated in CRC. FOXQ1, LGR5, CLDN1, KRT23, and DPEP1 were the top five upregulated in CRC. KRT23 expression could affect tumor stage and regional lymph node metastasis in CRC patients. FOXQ1 expression could affect tumor distant metastasis in CRC patients. Survival analysis indicated that SLC4A4 expression was associated with the prognosis of CRC patients. Prognostic prediction model developed based on age, tumor stage, and SLC4A4 expression exhibited an efficient performance in predicting 1-, 3-, and 5-year overall survival of CRC patients. In conclusion, the current study identified several genes and pathways related to CRC, which provided new insight in understanding molecular mechanism of tumorigenesis and development of CRC." @default.
• W3005229147 created "2020-02-14" @default.
• W3005229147 creator A5018289057 @default.
• W3005229147 creator A5059328215 @default.
• W3005229147 date "2020-04-01" @default.
• W3005229147 modified "2023-10-18" @default.
• W3005229147 title "Identification of Genes Related to Clinicopathological Characteristics and Prognosis of Patients with Colorectal Cancer" @default.
• W3005229147 cites W1672531970 @default.
• W3005229147 cites W1934094702 @default.
• W3005229147 cites W1967269413 @default.
• W3005229147 cites W1970086319 @default.
• W3005229147 cites W1993782263 @default.
• W3005229147 cites W2011762251 @default.
• W3005229147 cites W2027847170 @default.
• W3005229147 cites W2029884231 @default.
• W3005229147 cites W2034611055 @default.
• W3005229147 cites W2047781286 @default.
• W3005229147 cites W2057015734 @default.
• W3005229147 cites W2060090987 @default.
• W3005229147 cites W2064665589 @default.
• W3005229147 cites W2065703686 @default.
• W3005229147 cites W2071534941 @default.
• W3005229147 cites W2084001039 @default.
• W3005229147 cites W2094280155 @default.
• W3005229147 cites W2094867239 @default.
• W3005229147 cites W2133465414 @default.
• W3005229147 cites W2148888894 @default.
• W3005229147 cites W2158217645 @default.
• W3005229147 cites W2187869609 @default.
• W3005229147 cites W2262414037 @default.
• W3005229147 cites W2303834781 @default.
• W3005229147 cites W2328671688 @default.
• W3005229147 cites W2556424962 @default.
• W3005229147 cites W2560410506 @default.
• W3005229147 cites W2737376493 @default.
• W3005229147 cites W2761651864 @default.
• W3005229147 cites W2889646458 @default.
• W3005229147 cites W2891349395 @default.
• W3005229147 cites W2896629631 @default.
• W3005229147 cites W2897879617 @default.
• W3005229147 cites W2909675454 @default.
• W3005229147 cites W2912741456 @default.
• W3005229147 cites W2957075184 @default.
• W3005229147 cites W2957190895 @default.
• W3005229147 cites W2966418252 @default.
• W3005229147 cites W2980820582 @default.
• W3005229147 doi "https://doi.org/10.1089/dna.2019.5088" @default.
• W3005229147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32027181" @default.
• W3005229147 hasPublicationYear "2020" @default.
• W3005229147 type Work @default.
• W3005229147 sameAs 3005229147 @default.
• W3005229147 citedByCount "18" @default.
• W3005229147 countsByYear W30052291472020 @default.
• W3005229147 countsByYear W30052291472021 @default.
• W3005229147 countsByYear W30052291472022 @default.
• W3005229147 countsByYear W30052291472023 @default.
• W3005229147 crossrefType "journal-article" @default.
• W3005229147 hasAuthorship W3005229147A5018289057 @default.
• W3005229147 hasAuthorship W3005229147A5059328215 @default.
• W3005229147 hasBestOaLocation W30052291471 @default.
• W3005229147 hasConcept C10116572 @default.
• W3005229147 hasConcept C104317684 @default.
• W3005229147 hasConcept C121608353 @default.
• W3005229147 hasConcept C137620995 @default.
• W3005229147 hasConcept C143998085 @default.
• W3005229147 hasConcept C150194340 @default.
• W3005229147 hasConcept C152724338 @default.
• W3005229147 hasConcept C2779013556 @default.
• W3005229147 hasConcept C29537977 @default.
• W3005229147 hasConcept C2987395477 @default.
• W3005229147 hasConcept C502942594 @default.
• W3005229147 hasConcept C526805850 @default.
• W3005229147 hasConcept C54355233 @default.
• W3005229147 hasConcept C71924100 @default.
• W3005229147 hasConcept C86803240 @default.
• W3005229147 hasConceptScore W3005229147C10116572 @default.
• W3005229147 hasConceptScore W3005229147C104317684 @default.
• W3005229147 hasConceptScore W3005229147C121608353 @default.
• W3005229147 hasConceptScore W3005229147C137620995 @default.
• W3005229147 hasConceptScore W3005229147C143998085 @default.
• W3005229147 hasConceptScore W3005229147C150194340 @default.
• W3005229147 hasConceptScore W3005229147C152724338 @default.
• W3005229147 hasConceptScore W3005229147C2779013556 @default.
• W3005229147 hasConceptScore W3005229147C29537977 @default.
• W3005229147 hasConceptScore W3005229147C2987395477 @default.
• W3005229147 hasConceptScore W3005229147C502942594 @default.
• W3005229147 hasConceptScore W3005229147C526805850 @default.
• W3005229147 hasConceptScore W3005229147C54355233 @default.
• W3005229147 hasConceptScore W3005229147C71924100 @default.
• W3005229147 hasConceptScore W3005229147C86803240 @default.
• W3005229147 hasIssue "4" @default.
• W3005229147 hasLocation W30052291471 @default.
• W3005229147 hasLocation W30052291472 @default.
• W3005229147 hasOpenAccess W3005229147 @default.
• W3005229147 hasPrimaryLocation W30052291471 @default.
• W3005229147 hasRelatedWork W2009966535 @default.
• W3005229147 hasRelatedWork W2550335841 @default.
• W3005229147 hasRelatedWork W2763237291 @default.

• next