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• W3005234296 endingPage "100661" @default.
• W3005234296 startingPage "100661" @default.
• W3005234296 abstract "The hypothalamic-pituitary-interrenal axis is an important regulator of stress and metabolism in teleosts. Cortisol is secreted by the head kidney where it increases gluconeogenesis in the liver to increase circulating glucose levels. MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to the 3′ untranslated region of specific mRNA to regulate their expression. MicroRNAs can also be secreted into circulation by association with extracellular vesicles (EVs) where they can influence the phenotype of other tissues. In this study, adult rainbow trout were exposed to a 3-minute acute air stress and allowed to recover for 1-, 3-, or 24-h to determine how miRNAs were altered. MicroRNAs measured in this study were chosen based on their high relative abundance in tissues that drive the stress response (miR-21a-3p, let-7a-5p, miR-143-3p) or their role in regulating DNA methylation (miR-29a-3p). In general, miRNAs increased in circulating EVs during the recovery period while decreasing in head kidney and liver at the same timepoints. Predicted targets for these miRNAs were analyzed using KEGG and DAVID functional enrichment analysis. Pathways involved in metabolism and cell signaling were predicted to be upregulated. Future studies can use these results to investigate how pathways are regulated after stress. Overall, our results indicate that miRNAs are regulated during teleost stress responses and could be supporting the cortisol-mediated changes that occur." @default.
• W3005234296 created "2020-02-14" @default.
• W3005234296 creator A5020492505 @default.
• W3005234296 creator A5060127680 @default.
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• W3005234296 date "2020-06-01" @default.
• W3005234296 modified "2023-09-25" @default.
• W3005234296 title "Acute air exposure modulates the microRNA abundance in stress responsive tissues and circulating extracellular vesicles in rainbow trout (Oncorhynchus mykiss)" @default.
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• W3005234296 doi "https://doi.org/10.1016/j.cbd.2020.100661" @default.
• W3005234296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32062572" @default.
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