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- W3005277371 endingPage "264" @default.
- W3005277371 startingPage "235" @default.
- W3005277371 abstract "The insect excretory system contains two organ systems acting in concert: the Malpighian tubules and the hindgut perform essential roles in excretion and ionic and osmotic homeostasis. For over 350 years, these two organs have fascinated biologists as a model of organ structure and function. As part of a recent surge in interest, research on the Malpighian tubules and hindgut of Drosophila have uncovered important paradigms of organ physiology and development. Further, many human disease processes can be modeled in these organs. Here, focusing on discoveries in the past 10 years, we provide an overview of the anatomy and physiology of the Drosophila excretory system. We describe the major developmental events that build these organs during embryogenesis, remodel them during metamorphosis, and repair them following injury. Finally, we highlight the use of the Malpighian tubules and hindgut as accessible models of human disease biology. The Malpighian tubule is a particularly excellent model to study rapid fluid transport, neuroendocrine control of renal function, and modeling of numerous human renal conditions such as kidney stones, while the hindgut provides an outstanding model for processes such as the role of cell chirality in development, nonstem cell-based injury repair, cancer-promoting processes, and communication between the intestine and nervous system." @default.
- W3005277371 created "2020-02-14" @default.
- W3005277371 creator A5016477936 @default.
- W3005277371 creator A5045916438 @default.
- W3005277371 creator A5058785226 @default.
- W3005277371 creator A5072772917 @default.
- W3005277371 creator A5080774278 @default.
- W3005277371 date "2020-02-01" @default.
- W3005277371 modified "2023-10-09" @default.
- W3005277371 title "Physiology, Development, and Disease Modeling in the <i>Drosophila</i> Excretory System" @default.
- W3005277371 cites W1000137790 @default.
- W3005277371 cites W110806436 @default.
- W3005277371 cites W1496487857 @default.
- W3005277371 cites W1550665604 @default.
- W3005277371 cites W1558701786 @default.
- W3005277371 cites W1577728657 @default.
- W3005277371 cites W1581489141 @default.
- W3005277371 cites W1588821188 @default.
- W3005277371 cites W1592750332 @default.
- W3005277371 cites W1599764229 @default.
- W3005277371 cites W1828818916 @default.
- W3005277371 cites W1830588438 @default.
- W3005277371 cites W1847100997 @default.
- W3005277371 cites W1900367239 @default.
- W3005277371 cites W1921792876 @default.
- W3005277371 cites W1936948168 @default.
- W3005277371 cites W1964061190 @default.
- W3005277371 cites W1965271485 @default.
- W3005277371 cites W1965811247 @default.
- W3005277371 cites W1967573492 @default.
- W3005277371 cites W1968932382 @default.
- W3005277371 cites W1969288022 @default.
- W3005277371 cites W1971054818 @default.
- W3005277371 cites W1971135180 @default.
- W3005277371 cites W1971248187 @default.
- W3005277371 cites W1971823431 @default.
- W3005277371 cites W1972126834 @default.
- W3005277371 cites W1972472517 @default.
- W3005277371 cites W1972732131 @default.
- W3005277371 cites W1972819254 @default.
- W3005277371 cites W1973390409 @default.
- W3005277371 cites W1975473156 @default.
- W3005277371 cites W1976886596 @default.
- W3005277371 cites W1977178667 @default.
- W3005277371 cites W1977427601 @default.
- W3005277371 cites W1978297775 @default.
- W3005277371 cites W1980475684 @default.
- W3005277371 cites W1980593983 @default.
- W3005277371 cites W1981775758 @default.
- W3005277371 cites W1982289883 @default.
- W3005277371 cites W1982648436 @default.
- W3005277371 cites W1983146496 @default.
- W3005277371 cites W1983919553 @default.
- W3005277371 cites W1984162792 @default.
- W3005277371 cites W1984326321 @default.
- W3005277371 cites W1985296504 @default.
- W3005277371 cites W1985409672 @default.
- W3005277371 cites W1986559373 @default.
- W3005277371 cites W1988519721 @default.
- W3005277371 cites W1989629872 @default.
- W3005277371 cites W1989723819 @default.
- W3005277371 cites W1991484745 @default.
- W3005277371 cites W1991840769 @default.
- W3005277371 cites W1992098072 @default.
- W3005277371 cites W1992759659 @default.
- W3005277371 cites W1993742894 @default.
- W3005277371 cites W1993827187 @default.
- W3005277371 cites W1993953491 @default.
- W3005277371 cites W1994474166 @default.
- W3005277371 cites W1997226381 @default.
- W3005277371 cites W1997562981 @default.
- W3005277371 cites W1997906228 @default.
- W3005277371 cites W1998633662 @default.
- W3005277371 cites W1999623558 @default.
- W3005277371 cites W2002960522 @default.
- W3005277371 cites W2004630001 @default.
- W3005277371 cites W2008220154 @default.
- W3005277371 cites W2008276364 @default.
- W3005277371 cites W2009768359 @default.
- W3005277371 cites W2011599536 @default.
- W3005277371 cites W2012315737 @default.
- W3005277371 cites W2012427430 @default.
- W3005277371 cites W2014338155 @default.
- W3005277371 cites W2015244050 @default.
- W3005277371 cites W2015658156 @default.
- W3005277371 cites W2016348849 @default.
- W3005277371 cites W2016661249 @default.
- W3005277371 cites W2017520829 @default.
- W3005277371 cites W2017744076 @default.
- W3005277371 cites W2017944313 @default.
- W3005277371 cites W2018530807 @default.
- W3005277371 cites W2019424268 @default.
- W3005277371 cites W2019922737 @default.
- W3005277371 cites W2020300968 @default.
- W3005277371 cites W2022999092 @default.
- W3005277371 cites W2023276868 @default.
- W3005277371 cites W2023818938 @default.
- W3005277371 cites W2026287338 @default.