Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005282850> ?p ?o ?g. }
- W3005282850 endingPage "100958" @default.
- W3005282850 startingPage "100958" @default.
- W3005282850 abstract "In the pathogenesis of type 2 diabetes, development of insulin resistance triggers an increase in pancreatic β-cell insulin secretion capacity and β-cell number. Failure of this compensatory mechanism is caused by a dedifferentiation of β-cells, which leads to insufficient insulin secretion and diabetic hyperglycemia. The β-cell factors that normally protect against dedifferentiation remain poorly defined. Here, through a systems biology approach, we identify the transcription factor Klf6 as a regulator of β-cell adaptation to metabolic stress. We used a β-cell specific Klf6 knockout mouse model to investigate whether Klf6 may be a potential regulator of β-cell adaptation to a metabolic stress. We show that inactivation of Klf6 in β-cells blunts their proliferation induced by the insulin resistance of pregnancy, high-fat high-sucrose feeding, and insulin receptor antagonism. Transcriptomic analysis showed that Klf6 controls the expression of β-cell proliferation genes and, in the presence of insulin resistance, it prevents the down-expression of genes controlling mature β-cell identity and the induction of disallowed genes that impair insulin secretion. Its expression also limits the transdifferentiation of β-cells into α-cells. Our study identifies a new transcription factor that protects β-cells against dedifferentiation, and which may be targeted to prevent diabetes development." @default.
- W3005282850 created "2020-02-14" @default.
- W3005282850 creator A5001478163 @default.
- W3005282850 creator A5003489579 @default.
- W3005282850 creator A5004559033 @default.
- W3005282850 creator A5013796467 @default.
- W3005282850 creator A5016400556 @default.
- W3005282850 creator A5018394560 @default.
- W3005282850 creator A5065158949 @default.
- W3005282850 creator A5079729308 @default.
- W3005282850 date "2020-05-01" @default.
- W3005282850 modified "2023-10-16" @default.
- W3005282850 title "Klf6 protects β-cells against insulin resistance-induced dedifferentiation" @default.
- W3005282850 cites W1598254642 @default.
- W3005282850 cites W1828613304 @default.
- W3005282850 cites W1966327575 @default.
- W3005282850 cites W1966880393 @default.
- W3005282850 cites W1967766455 @default.
- W3005282850 cites W1972124642 @default.
- W3005282850 cites W1984403454 @default.
- W3005282850 cites W1997174471 @default.
- W3005282850 cites W2000977514 @default.
- W3005282850 cites W2011220884 @default.
- W3005282850 cites W2016312170 @default.
- W3005282850 cites W2025410324 @default.
- W3005282850 cites W2032889432 @default.
- W3005282850 cites W2033204276 @default.
- W3005282850 cites W2039701037 @default.
- W3005282850 cites W2041986831 @default.
- W3005282850 cites W2042362312 @default.
- W3005282850 cites W2044801034 @default.
- W3005282850 cites W2047459673 @default.
- W3005282850 cites W2054479025 @default.
- W3005282850 cites W2061574308 @default.
- W3005282850 cites W2062931044 @default.
- W3005282850 cites W2065462171 @default.
- W3005282850 cites W2075045064 @default.
- W3005282850 cites W2075186231 @default.
- W3005282850 cites W2079945852 @default.
- W3005282850 cites W2082515526 @default.
- W3005282850 cites W2082951519 @default.
- W3005282850 cites W2085313098 @default.
- W3005282850 cites W2091035564 @default.
- W3005282850 cites W2102456086 @default.
- W3005282850 cites W2106223802 @default.
- W3005282850 cites W2107581350 @default.
- W3005282850 cites W2108781675 @default.
- W3005282850 cites W2109310039 @default.
- W3005282850 cites W2113544353 @default.
- W3005282850 cites W2114104545 @default.
- W3005282850 cites W2119239003 @default.
- W3005282850 cites W2134526812 @default.
- W3005282850 cites W2140883834 @default.
- W3005282850 cites W2163146250 @default.
- W3005282850 cites W2167357721 @default.
- W3005282850 cites W2169456326 @default.
- W3005282850 cites W2180524506 @default.
- W3005282850 cites W2199891677 @default.
- W3005282850 cites W2397505559 @default.
- W3005282850 cites W2491000530 @default.
- W3005282850 cites W2511574967 @default.
- W3005282850 cites W2554644553 @default.
- W3005282850 cites W2560349316 @default.
- W3005282850 cites W2580270810 @default.
- W3005282850 cites W2602714645 @default.
- W3005282850 cites W2619236098 @default.
- W3005282850 cites W2624357844 @default.
- W3005282850 cites W2769915960 @default.
- W3005282850 cites W2786903684 @default.
- W3005282850 cites W2793763712 @default.
- W3005282850 cites W2801983486 @default.
- W3005282850 cites W2891701817 @default.
- W3005282850 cites W2897204017 @default.
- W3005282850 doi "https://doi.org/10.1016/j.molmet.2020.02.001" @default.
- W3005282850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7093812" @default.
- W3005282850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32244185" @default.
- W3005282850 hasPublicationYear "2020" @default.
- W3005282850 type Work @default.
- W3005282850 sameAs 3005282850 @default.
- W3005282850 citedByCount "10" @default.
- W3005282850 countsByYear W30052828502020 @default.
- W3005282850 countsByYear W30052828502021 @default.
- W3005282850 countsByYear W30052828502022 @default.
- W3005282850 countsByYear W30052828502023 @default.
- W3005282850 crossrefType "journal-article" @default.
- W3005282850 hasAuthorship W3005282850A5001478163 @default.
- W3005282850 hasAuthorship W3005282850A5003489579 @default.
- W3005282850 hasAuthorship W3005282850A5004559033 @default.
- W3005282850 hasAuthorship W3005282850A5013796467 @default.
- W3005282850 hasAuthorship W3005282850A5016400556 @default.
- W3005282850 hasAuthorship W3005282850A5018394560 @default.
- W3005282850 hasAuthorship W3005282850A5065158949 @default.
- W3005282850 hasAuthorship W3005282850A5079729308 @default.
- W3005282850 hasBestOaLocation W30052828501 @default.
- W3005282850 hasConcept C104317684 @default.
- W3005282850 hasConcept C126322002 @default.
- W3005282850 hasConcept C127561419 @default.
- W3005282850 hasConcept C134018914 @default.