FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005286543> ?p ?o ?g. }

• W3005286543 endingPage "981" @default.
• W3005286543 startingPage "975" @default.
• W3005286543 abstract "Background Unexplained cardiac arrest (UCA) is rare in children. Despite investigations, the etiology in up to one-half of patients remains unknown. Objective The purpose of this study was to assess the management and outcomes of pediatric UCA survivors through the Canadian Pediatric Heart Rhythm Network. Methods A retrospective case series of children (age 1–19 years) who presented with UCA between January 1, 2004, and November 1, 2017, was conducted. Patients with known heart disease pre-UCA were excluded. UCA details, investigations, genetic test results, treatment, implantable cardioverter–defibrillator (ICD) data, subsequent diagnoses, and family screening data were collected. Results Forty-six patients (61% male) were survivors of sudden unexpected death and met inclusion criteria at 8 participating sites. Median age at UCA was 13.8 years (interquartile range [IQR] 9–16 years). Baseline retrievable investigations included electrocardiogram (96%), echocardiogram (85%), exercise stress test (73%), and cardiac magnetic resonance imaging (57%). The presumed etiology for the UCA was identified in 24 (52%), mainly long QT syndrome or catecholaminergic polymorphic ventricular tachycardia. Genetic testing was performed in 33 of 46 (72%), with pathogenic/likely pathogenic variants identified in 13 of 33 (39%) and variants of uncertain significance in 8 of 33 (24%). ICDs were implanted in 35 of 46 (76%). Over median follow-up of 36 months (IQR 17–57 months), 8 of 35 had arrhythmia events captured on device interrogation. Families of 26 of 46 patients(57%) underwent screening, leading to a cardiac diagnosis in 6 of 26 families. Conclusion A cause for UCA was not identified in nearly 50% of patients despite extensive investigations, including cascade screening. A large proportion (75%) of ICD shocks occurred in patients without a diagnosis. Unexplained cardiac arrest (UCA) is rare in children. Despite investigations, the etiology in up to one-half of patients remains unknown. The purpose of this study was to assess the management and outcomes of pediatric UCA survivors through the Canadian Pediatric Heart Rhythm Network. A retrospective case series of children (age 1–19 years) who presented with UCA between January 1, 2004, and November 1, 2017, was conducted. Patients with known heart disease pre-UCA were excluded. UCA details, investigations, genetic test results, treatment, implantable cardioverter–defibrillator (ICD) data, subsequent diagnoses, and family screening data were collected. Forty-six patients (61% male) were survivors of sudden unexpected death and met inclusion criteria at 8 participating sites. Median age at UCA was 13.8 years (interquartile range [IQR] 9–16 years). Baseline retrievable investigations included electrocardiogram (96%), echocardiogram (85%), exercise stress test (73%), and cardiac magnetic resonance imaging (57%). The presumed etiology for the UCA was identified in 24 (52%), mainly long QT syndrome or catecholaminergic polymorphic ventricular tachycardia. Genetic testing was performed in 33 of 46 (72%), with pathogenic/likely pathogenic variants identified in 13 of 33 (39%) and variants of uncertain significance in 8 of 33 (24%). ICDs were implanted in 35 of 46 (76%). Over median follow-up of 36 months (IQR 17–57 months), 8 of 35 had arrhythmia events captured on device interrogation. Families of 26 of 46 patients(57%) underwent screening, leading to a cardiac diagnosis in 6 of 26 families. A cause for UCA was not identified in nearly 50% of patients despite extensive investigations, including cascade screening. A large proportion (75%) of ICD shocks occurred in patients without a diagnosis." @default.
• W3005286543 created "2020-02-14" @default.
• W3005286543 creator A5004161178 @default.
• W3005286543 creator A5005764816 @default.
• W3005286543 creator A5006188466 @default.
• W3005286543 creator A5010520939 @default.
• W3005286543 creator A5013011824 @default.
• W3005286543 creator A5014709243 @default.
• W3005286543 creator A5043247929 @default.
• W3005286543 creator A5048413881 @default.
• W3005286543 creator A5054486546 @default.
• W3005286543 creator A5058650138 @default.
• W3005286543 creator A5077883213 @default.
• W3005286543 creator A5083075230 @default.
• W3005286543 creator A5083126631 @default.
• W3005286543 creator A5087003356 @default.
• W3005286543 date "2020-06-01" @default.
• W3005286543 modified "2023-10-17" @default.
• W3005286543 title "Initially unexplained cardiac arrest in children and adolescents: A national experience from the Canadian Pediatric Heart Rhythm Network" @default.
• W3005286543 cites W1993190948 @default.
• W3005286543 cites W2013037390 @default.
• W3005286543 cites W2014096969 @default.
• W3005286543 cites W2037233353 @default.
• W3005286543 cites W2046336333 @default.
• W3005286543 cites W2051759345 @default.
• W3005286543 cites W2051978340 @default.
• W3005286543 cites W2069240034 @default.
• W3005286543 cites W2087358757 @default.
• W3005286543 cites W2093274439 @default.
• W3005286543 cites W2111297252 @default.
• W3005286543 cites W2135570564 @default.
• W3005286543 cites W2474247475 @default.
• W3005286543 cites W2578427537 @default.
• W3005286543 cites W2609828677 @default.
• W3005286543 cites W2746151575 @default.
• W3005286543 cites W2765408474 @default.
• W3005286543 cites W2794309657 @default.
• W3005286543 cites W2886470177 @default.
• W3005286543 cites W2897529045 @default.
• W3005286543 cites W2899874978 @default.
• W3005286543 cites W2902868084 @default.
• W3005286543 cites W2921726358 @default.
• W3005286543 cites W2937379907 @default.
• W3005286543 cites W2938483225 @default.
• W3005286543 cites W2942535798 @default.
• W3005286543 cites W2944451021 @default.
• W3005286543 cites W2968389173 @default.
• W3005286543 cites W2979440433 @default.
• W3005286543 cites W2981350677 @default.
• W3005286543 cites W2982007831 @default.
• W3005286543 doi "https://doi.org/10.1016/j.hrthm.2020.01.030" @default.
• W3005286543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32036023" @default.
• W3005286543 hasPublicationYear "2020" @default.
• W3005286543 type Work @default.
• W3005286543 sameAs 3005286543 @default.
• W3005286543 citedByCount "20" @default.
• W3005286543 countsByYear W30052865432020 @default.
• W3005286543 countsByYear W30052865432021 @default.
• W3005286543 countsByYear W30052865432022 @default.
• W3005286543 countsByYear W30052865432023 @default.
• W3005286543 crossrefType "journal-article" @default.
• W3005286543 hasAuthorship W3005286543A5004161178 @default.
• W3005286543 hasAuthorship W3005286543A5005764816 @default.
• W3005286543 hasAuthorship W3005286543A5006188466 @default.
• W3005286543 hasAuthorship W3005286543A5010520939 @default.
• W3005286543 hasAuthorship W3005286543A5013011824 @default.
• W3005286543 hasAuthorship W3005286543A5014709243 @default.
• W3005286543 hasAuthorship W3005286543A5043247929 @default.
• W3005286543 hasAuthorship W3005286543A5048413881 @default.
• W3005286543 hasAuthorship W3005286543A5054486546 @default.
• W3005286543 hasAuthorship W3005286543A5058650138 @default.
• W3005286543 hasAuthorship W3005286543A5077883213 @default.
• W3005286543 hasAuthorship W3005286543A5083075230 @default.
• W3005286543 hasAuthorship W3005286543A5083126631 @default.
• W3005286543 hasAuthorship W3005286543A5087003356 @default.
• W3005286543 hasConcept C113217602 @default.
• W3005286543 hasConcept C118441451 @default.
• W3005286543 hasConcept C119060515 @default.
• W3005286543 hasConcept C126322002 @default.
• W3005286543 hasConcept C126838900 @default.
• W3005286543 hasConcept C137627325 @default.
• W3005286543 hasConcept C143409427 @default.
• W3005286543 hasConcept C164705383 @default.
• W3005286543 hasConcept C167135981 @default.
• W3005286543 hasConcept C187212893 @default.
• W3005286543 hasConcept C190712762 @default.
• W3005286543 hasConcept C2775935837 @default.
• W3005286543 hasConcept C2776008845 @default.
• W3005286543 hasConcept C2777093960 @default.
• W3005286543 hasConcept C2778178275 @default.
• W3005286543 hasConcept C2778550298 @default.
• W3005286543 hasConcept C2779703243 @default.
• W3005286543 hasConcept C2780074459 @default.
• W3005286543 hasConcept C2780673598 @default.
• W3005286543 hasConcept C519063684 @default.
• W3005286543 hasConcept C71924100 @default.
• W3005286543 hasConceptScore W3005286543C113217602 @default.
• W3005286543 hasConceptScore W3005286543C118441451 @default.

• next