Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005308085> ?p ?o ?g. }
- W3005308085 endingPage "713" @default.
- W3005308085 startingPage "707" @default.
- W3005308085 abstract "Abstract Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases . In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD‐induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25 mg/kg/d) andrographolide treatment (n = 9), and high dose (50 mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac‐damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro‐apoptotic proteins and decrease in the proteins of IGF‐1R‐survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients." @default.
- W3005308085 created "2020-02-14" @default.
- W3005308085 creator A5012928424 @default.
- W3005308085 creator A5017165971 @default.
- W3005308085 creator A5017685734 @default.
- W3005308085 creator A5018030867 @default.
- W3005308085 creator A5021833769 @default.
- W3005308085 creator A5025617602 @default.
- W3005308085 creator A5056909923 @default.
- W3005308085 creator A5060018552 @default.
- W3005308085 creator A5068473356 @default.
- W3005308085 creator A5088920111 @default.
- W3005308085 date "2020-02-05" @default.
- W3005308085 modified "2023-09-26" @default.
- W3005308085 title "Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice" @default.
- W3005308085 cites W1538480688 @default.
- W3005308085 cites W1780953923 @default.
- W3005308085 cites W1830354926 @default.
- W3005308085 cites W1969616829 @default.
- W3005308085 cites W1970588308 @default.
- W3005308085 cites W1971658576 @default.
- W3005308085 cites W1975393873 @default.
- W3005308085 cites W1978327276 @default.
- W3005308085 cites W1979814671 @default.
- W3005308085 cites W1992369107 @default.
- W3005308085 cites W2001332591 @default.
- W3005308085 cites W2002235860 @default.
- W3005308085 cites W2005012161 @default.
- W3005308085 cites W2014508219 @default.
- W3005308085 cites W2021859106 @default.
- W3005308085 cites W2025555937 @default.
- W3005308085 cites W2026211921 @default.
- W3005308085 cites W2044258256 @default.
- W3005308085 cites W2045985825 @default.
- W3005308085 cites W2054639370 @default.
- W3005308085 cites W2056323898 @default.
- W3005308085 cites W2061085222 @default.
- W3005308085 cites W2064891141 @default.
- W3005308085 cites W2092981916 @default.
- W3005308085 cites W2142295958 @default.
- W3005308085 cites W2150713228 @default.
- W3005308085 cites W2153550994 @default.
- W3005308085 cites W2156865358 @default.
- W3005308085 cites W2277131177 @default.
- W3005308085 cites W2300067247 @default.
- W3005308085 cites W2340248743 @default.
- W3005308085 cites W2471624367 @default.
- W3005308085 cites W2474517402 @default.
- W3005308085 cites W2531361274 @default.
- W3005308085 cites W2624112502 @default.
- W3005308085 cites W2753370738 @default.
- W3005308085 cites W2770148231 @default.
- W3005308085 cites W2793922952 @default.
- W3005308085 cites W2903054445 @default.
- W3005308085 cites W2945576368 @default.
- W3005308085 cites W2947930584 @default.
- W3005308085 doi "https://doi.org/10.1002/tox.22906" @default.
- W3005308085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32023008" @default.
- W3005308085 hasPublicationYear "2020" @default.
- W3005308085 type Work @default.
- W3005308085 sameAs 3005308085 @default.
- W3005308085 citedByCount "8" @default.
- W3005308085 countsByYear W30053080852021 @default.
- W3005308085 countsByYear W30053080852022 @default.
- W3005308085 countsByYear W30053080852023 @default.
- W3005308085 crossrefType "journal-article" @default.
- W3005308085 hasAuthorship W3005308085A5012928424 @default.
- W3005308085 hasAuthorship W3005308085A5017165971 @default.
- W3005308085 hasAuthorship W3005308085A5017685734 @default.
- W3005308085 hasAuthorship W3005308085A5018030867 @default.
- W3005308085 hasAuthorship W3005308085A5021833769 @default.
- W3005308085 hasAuthorship W3005308085A5025617602 @default.
- W3005308085 hasAuthorship W3005308085A5056909923 @default.
- W3005308085 hasAuthorship W3005308085A5060018552 @default.
- W3005308085 hasAuthorship W3005308085A5068473356 @default.
- W3005308085 hasAuthorship W3005308085A5088920111 @default.
- W3005308085 hasConcept C104317684 @default.
- W3005308085 hasConcept C126322002 @default.
- W3005308085 hasConcept C134018914 @default.
- W3005308085 hasConcept C142724271 @default.
- W3005308085 hasConcept C185592680 @default.
- W3005308085 hasConcept C190283241 @default.
- W3005308085 hasConcept C204787440 @default.
- W3005308085 hasConcept C2776415932 @default.
- W3005308085 hasConcept C2777477808 @default.
- W3005308085 hasConcept C2777970627 @default.
- W3005308085 hasConcept C2781357234 @default.
- W3005308085 hasConcept C55493867 @default.
- W3005308085 hasConcept C71924100 @default.
- W3005308085 hasConcept C98274493 @default.
- W3005308085 hasConceptScore W3005308085C104317684 @default.
- W3005308085 hasConceptScore W3005308085C126322002 @default.
- W3005308085 hasConceptScore W3005308085C134018914 @default.
- W3005308085 hasConceptScore W3005308085C142724271 @default.
- W3005308085 hasConceptScore W3005308085C185592680 @default.
- W3005308085 hasConceptScore W3005308085C190283241 @default.
- W3005308085 hasConceptScore W3005308085C204787440 @default.
- W3005308085 hasConceptScore W3005308085C2776415932 @default.