FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005308306> ?p ?o ?g. }

• W3005308306 endingPage "1019" @default.
• W3005308306 startingPage "1019" @default.
• W3005308306 abstract "Bioactive sphingolipids are emerging as key regulators of vascular function and homeostasis. While most of the clinical studies have been devoted to profile circulating sphingolipids in maternal plasma, little is known about the role of the sphingolipid at the feto-placental vasculature, which is in direct contact with the offspring circulation. Our study aims to compare the sphingolipid profile of normal with preeclamptic (PE) placental chorionic arteries and isolated endothelial cells, with the goal of unveiling potential underlying pathomechanisms in the vasculature. Dihydrosphingosine and sphingomyelin (SM) concentrations (C16:0-, C18:0-, and C24:0- sphingomyelin) were significantly increased in chorionic arteries of preeclamptic placentas, whereas total ceramide, although showing a downward trend, were not statistically different. Moreover, RNA and immunofluorescence analysis showed impaired sphingosine-1-phosphate (S1P) synthesis and signaling in PE vessels. Our data reveal that the exposure to a deranged maternal intrauterine environment during PE alters the sphingolipid signature and gene expression on the fetal side of the placental vasculature. This pathological remodeling consists in increased serine palmitoyltransferase (SPT) activity and SM accrual in PE chorionic arteries, with concomitance impairment endothelial S1P signaling in the endothelium of these vessels. The increase of endothelial S1P phosphatase, lyase and S1PR2, and blunted S1PR1 expression support the onset of the pathological phenotype in chorionic arteries." @default.
• W3005308306 created "2020-02-14" @default.
• W3005308306 creator A5015449382 @default.
• W3005308306 creator A5020023127 @default.
• W3005308306 creator A5040546254 @default.
• W3005308306 creator A5051060926 @default.
• W3005308306 date "2020-02-04" @default.
• W3005308306 modified "2023-10-15" @default.
• W3005308306 title "Sphingolipid Signature of Human Feto-Placental Vasculature in Preeclampsia" @default.
• W3005308306 cites W1256777839 @default.
• W3005308306 cites W1479945039 @default.
• W3005308306 cites W1548865387 @default.
• W3005308306 cites W163997156 @default.
• W3005308306 cites W1780976067 @default.
• W3005308306 cites W1830235003 @default.
• W3005308306 cites W1874766814 @default.
• W3005308306 cites W1904040437 @default.
• W3005308306 cites W1963535811 @default.
• W3005308306 cites W1972668725 @default.
• W3005308306 cites W1987110992 @default.
• W3005308306 cites W1989979087 @default.
• W3005308306 cites W1992495544 @default.
• W3005308306 cites W1992800416 @default.
• W3005308306 cites W1993511853 @default.
• W3005308306 cites W1998546556 @default.
• W3005308306 cites W2005467120 @default.
• W3005308306 cites W2013455971 @default.
• W3005308306 cites W2017561698 @default.
• W3005308306 cites W2021286914 @default.
• W3005308306 cites W2032983932 @default.
• W3005308306 cites W2035339090 @default.
• W3005308306 cites W2042864107 @default.
• W3005308306 cites W2043112660 @default.
• W3005308306 cites W2043257102 @default.
• W3005308306 cites W2044310963 @default.
• W3005308306 cites W2048085891 @default.
• W3005308306 cites W2057888633 @default.
• W3005308306 cites W2059820110 @default.
• W3005308306 cites W2066580165 @default.
• W3005308306 cites W2069056765 @default.
• W3005308306 cites W2074133251 @default.
• W3005308306 cites W2075923153 @default.
• W3005308306 cites W2093816724 @default.
• W3005308306 cites W2109699745 @default.
• W3005308306 cites W2110657050 @default.
• W3005308306 cites W2115764880 @default.
• W3005308306 cites W2116861212 @default.
• W3005308306 cites W2120722240 @default.
• W3005308306 cites W2128925208 @default.
• W3005308306 cites W2133980433 @default.
• W3005308306 cites W2139702681 @default.
• W3005308306 cites W2145985395 @default.
• W3005308306 cites W2152311269 @default.
• W3005308306 cites W2155255997 @default.
• W3005308306 cites W2159801302 @default.
• W3005308306 cites W2162940414 @default.
• W3005308306 cites W2166848649 @default.
• W3005308306 cites W2182953133 @default.
• W3005308306 cites W2286662779 @default.
• W3005308306 cites W2292396785 @default.
• W3005308306 cites W2337748813 @default.
• W3005308306 cites W2341276202 @default.
• W3005308306 cites W2415863871 @default.
• W3005308306 cites W2419344209 @default.
• W3005308306 cites W2422279459 @default.
• W3005308306 cites W2549729760 @default.
• W3005308306 cites W2599072622 @default.
• W3005308306 cites W2604951002 @default.
• W3005308306 cites W2613565317 @default.
• W3005308306 cites W2618617063 @default.
• W3005308306 cites W2624796529 @default.
• W3005308306 cites W2754791272 @default.
• W3005308306 cites W2768617092 @default.
• W3005308306 cites W2800320377 @default.
• W3005308306 cites W2809444289 @default.
• W3005308306 cites W2888234192 @default.
• W3005308306 cites W2893658376 @default.
• W3005308306 cites W2999647386 @default.
• W3005308306 doi "https://doi.org/10.3390/ijms21031019" @default.
• W3005308306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7037072" @default.
• W3005308306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32033121" @default.
• W3005308306 hasPublicationYear "2020" @default.
• W3005308306 type Work @default.
• W3005308306 sameAs 3005308306 @default.
• W3005308306 citedByCount "25" @default.
• W3005308306 countsByYear W30053083062020 @default.
• W3005308306 countsByYear W30053083062021 @default.
• W3005308306 countsByYear W30053083062022 @default.
• W3005308306 countsByYear W30053083062023 @default.
• W3005308306 crossrefType "journal-article" @default.
• W3005308306 hasAuthorship W3005308306A5015449382 @default.
• W3005308306 hasAuthorship W3005308306A5020023127 @default.
• W3005308306 hasAuthorship W3005308306A5040546254 @default.
• W3005308306 hasAuthorship W3005308306A5051060926 @default.
• W3005308306 hasBestOaLocation W30053083061 @default.
• W3005308306 hasConcept C126322002 @default.
• W3005308306 hasConcept C134018914 @default.
• W3005308306 hasConcept C170493617 @default.

• next