Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005311704> ?p ?o ?g. }
- W3005311704 endingPage "127" @default.
- W3005311704 startingPage "115" @default.
- W3005311704 abstract "Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) are essential for normal energy homeostasis. Maximal ARC Pomc transcription is dependent on neuronal Pomc enhancer 1 (nPE1), located 12 kb upstream from the promoter. Selective deletion of nPE1 in mice decreases ARC Pomc expression by 70%, sufficient to induce mild obesity. Because nPE1 is located exclusively in the genomes of placental mammals, we questioned whether its hypomorphic mutation would also alter placental Pomc expression and the metabolic adaptations associated with pregnancy and lactation. We assessed placental development, pup growth, circulating leptin and expression of Pomc , Agrp and alternatively spliced leptin receptor ( LepR ) isoforms in the ARC and placenta of Pomc ∆1/∆1 and Pomc +/+ dams. Despite indistinguishable body weights, lean mass, food intake, placental histology and Pomc expression and overall pregnancy outcomes between the genotypes, Pomc ∆1/∆1 females had increased pre-pregnancy fat mass that paradoxically decreased to control levels by parturition. However, Pomc ∆1/∆1 dams had exaggerated increases in circulating leptin, up to twice of that of the typically elevated levels in Pomc +/+ mice at the end of pregnancy, despite their equivalent fat mass. Pomc ∆1/∆1 dams also had increased placental expression of soluble leptin receptor ( LepRe ), although the protein levels of LEPRE in circulation were the same as Pomc +/+ controls. Together, these data suggest that the hypomorphic Pomc ∆1/∆1 allele is responsible for the perinatal super hyperleptinemia of Pomc ∆1/∆1 dams, possibly due to upregulated leptin secretion from individual adipocytes." @default.
- W3005311704 created "2020-02-14" @default.
- W3005311704 creator A5012299131 @default.
- W3005311704 creator A5023245885 @default.
- W3005311704 creator A5031799744 @default.
- W3005311704 creator A5049987678 @default.
- W3005311704 creator A5058397082 @default.
- W3005311704 creator A5059469452 @default.
- W3005311704 creator A5068105950 @default.
- W3005311704 creator A5068462755 @default.
- W3005311704 date "2020-04-01" @default.
- W3005311704 modified "2023-10-07" @default.
- W3005311704 title "Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy" @default.
- W3005311704 cites W1506453366 @default.
- W3005311704 cites W1964046220 @default.
- W3005311704 cites W1970508192 @default.
- W3005311704 cites W1972116648 @default.
- W3005311704 cites W1972401547 @default.
- W3005311704 cites W1987166486 @default.
- W3005311704 cites W1996737480 @default.
- W3005311704 cites W1997157145 @default.
- W3005311704 cites W2003990479 @default.
- W3005311704 cites W2008602426 @default.
- W3005311704 cites W2013865699 @default.
- W3005311704 cites W2016994959 @default.
- W3005311704 cites W2021432134 @default.
- W3005311704 cites W2023990552 @default.
- W3005311704 cites W2028377061 @default.
- W3005311704 cites W2028548770 @default.
- W3005311704 cites W2030012045 @default.
- W3005311704 cites W2030220097 @default.
- W3005311704 cites W2037883415 @default.
- W3005311704 cites W2050128775 @default.
- W3005311704 cites W2053815511 @default.
- W3005311704 cites W2055956383 @default.
- W3005311704 cites W2056383195 @default.
- W3005311704 cites W2058999737 @default.
- W3005311704 cites W2073869932 @default.
- W3005311704 cites W2075739994 @default.
- W3005311704 cites W2077453058 @default.
- W3005311704 cites W2078506029 @default.
- W3005311704 cites W2086923774 @default.
- W3005311704 cites W2093028431 @default.
- W3005311704 cites W2094481749 @default.
- W3005311704 cites W2095843453 @default.
- W3005311704 cites W2099367948 @default.
- W3005311704 cites W2101921785 @default.
- W3005311704 cites W2102367052 @default.
- W3005311704 cites W2103270369 @default.
- W3005311704 cites W2103413882 @default.
- W3005311704 cites W2111734250 @default.
- W3005311704 cites W2113511096 @default.
- W3005311704 cites W2114758748 @default.
- W3005311704 cites W2120512098 @default.
- W3005311704 cites W2122607033 @default.
- W3005311704 cites W2131636957 @default.
- W3005311704 cites W2140925859 @default.
- W3005311704 cites W2154900520 @default.
- W3005311704 cites W2156167660 @default.
- W3005311704 cites W2266322142 @default.
- W3005311704 cites W2335343055 @default.
- W3005311704 cites W2735883686 @default.
- W3005311704 cites W2757036626 @default.
- W3005311704 cites W2788781113 @default.
- W3005311704 cites W2790243492 @default.
- W3005311704 cites W2885236704 @default.
- W3005311704 cites W2887739248 @default.
- W3005311704 cites W2894011049 @default.
- W3005311704 cites W2920625200 @default.
- W3005311704 cites W2921684086 @default.
- W3005311704 cites W2921779614 @default.
- W3005311704 cites W2960774465 @default.
- W3005311704 doi "https://doi.org/10.1530/joe-19-0576" @default.
- W3005311704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7098466" @default.
- W3005311704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32027603" @default.
- W3005311704 hasPublicationYear "2020" @default.
- W3005311704 type Work @default.
- W3005311704 sameAs 3005311704 @default.
- W3005311704 citedByCount "5" @default.
- W3005311704 countsByYear W30053117042020 @default.
- W3005311704 countsByYear W30053117042021 @default.
- W3005311704 countsByYear W30053117042022 @default.
- W3005311704 countsByYear W30053117042023 @default.
- W3005311704 crossrefType "journal-article" @default.
- W3005311704 hasAuthorship W3005311704A5012299131 @default.
- W3005311704 hasAuthorship W3005311704A5023245885 @default.
- W3005311704 hasAuthorship W3005311704A5031799744 @default.
- W3005311704 hasAuthorship W3005311704A5049987678 @default.
- W3005311704 hasAuthorship W3005311704A5058397082 @default.
- W3005311704 hasAuthorship W3005311704A5059469452 @default.
- W3005311704 hasAuthorship W3005311704A5068105950 @default.
- W3005311704 hasAuthorship W3005311704A5068462755 @default.
- W3005311704 hasBestOaLocation W30053117041 @default.
- W3005311704 hasConcept C126322002 @default.
- W3005311704 hasConcept C134018914 @default.
- W3005311704 hasConcept C14372207 @default.
- W3005311704 hasConcept C172680121 @default.
- W3005311704 hasConcept C2524010 @default.