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- W3005322083 abstract "Atrial fibrillation (AF) is the most frequent cardiac arrhythmia. Several cases of AF patients present an increased level of interleukin 1β (IL-1β). Thus, this work aims to test the hypothesis that IL-1β is involved in the physiopathology of AF. We compared adult C57BL/6 mice subcutaneously daily-treated with IL-1β (IL-1β) or with vehicle (Control) for 15 days. Atrial action potential (AP) and Ca2+ transients were recorded by Local Field Fluorescence Microscopy, at intact heart level. IL-1β treated mice showed shorter atrial AP duration (APD) when compared to control hearts at 30, 50 and 70% of repolarization. When the hearts were externally paced at 7 Hz, APD30 (Control vs IL-1β: Mean ± SD): 11.2 ± 2.5 ms vs 8.6 ± 2.7 ms, APD50: 18.1 ± 3.7 ms vs 13.1 ± 2.9 ms, and APD70: 31.4 ± 7.2 ms vs 22.3 ± 5.6 ms. Although, APD highly depends on the heart rate, the relative differences between control vs. IL-1β did not change at a higher pacing rate (10Hz). Ca2+ transients had faster kinetics in IL-1β treated mice. Rise time (RT): 13.2 ± 2.6 ms vs 9.2 ± 1.1 ms, and fall time (FT): 63.3 ± 9.3 ms vs 50.3 ± 9.3 ms. After perfusion with ryanodine (2µM) and thapsigargin (2µM), RT and FT had a lower reduction in IL-1β treated hearts. ΔRT: 22.1% ± 23.3% vs 4.6% ± 20.7%, and ΔFT: 30.15% ± 25.5% vs 0.9% ± 19.7%. Additionally, the IL-1β treated group presented a higher number of arrhythmic triggered events after a S1-S2 simulation protocol (Control = 1/10 vs. IL-1β = 7/13 mice). In conclusion, the results presented suggest that IL-1β produces changes on APD and Ca2+ management in atrial cardiomyocytes that could be involved on the genesis of atrial fibrillation." @default.
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- W3005322083 date "2020-02-01" @default.
- W3005322083 modified "2023-09-26" @default.
- W3005322083 title "The Role of IL-1β on Atrial Fibrillation Physiopathology" @default.
- W3005322083 doi "https://doi.org/10.1016/j.bpj.2019.11.3100" @default.
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