Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005354171> ?p ?o ?g. }
- W3005354171 endingPage "107327482090469" @default.
- W3005354171 startingPage "107327482090469" @default.
- W3005354171 abstract "Gastric cancer is one of the most common malignant tumors worldwide, and for resectable tumors, the most effective treatment is surgery with chemotherapy in neoadjuvant or adjuvant setting. However, the majority of patients fail to achieve the ideal initial response and/or develop resistance to chemotherapy. It was reported that long noncoding RNA regulator of reprogramming (ROR) is highly associated with the progression of gastric cancer. However, the role ROR in multidrug resistance (MDR) remains unclear.The messenger RNA levels of 63 specimens of patients with gastric cancer were determined by real-time polymerase chain reaction analysis and were correlated with drug resistance and survival of patients. To determine the cellular functions of ROR, we generated gastric cancer MDR cells. The effect of ROR depletion on multidrug resistance-associated protein 1 (MRP1) expression and cell apoptosis were examined by immunoblotting analyses, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and flow cytometry.We found that ROR expression levels are positively associated with increased MDR and poor prognosis of patients with gastric cancer. Regulator of reprogramming expression is increased in gastric cancer cells resistant to adriamycin (ADR) and vincristine (VCR). Depletion of ROR reduced MRP1 expression and increased apoptosis of drug-resistant gastric cancer cells in response to ADR and VCR treatment.We demonstrated that ROR expression promotes MRP1 expression and MDR of gastric cancer cells and is correlated with increased MDR and poor prognosis of patients with gastric cancer. Our finding highlighted the potential of targeting ROR to improve the efficacy of chemotherapy." @default.
- W3005354171 created "2020-02-14" @default.
- W3005354171 creator A5003715754 @default.
- W3005354171 creator A5006901857 @default.
- W3005354171 creator A5014626837 @default.
- W3005354171 creator A5019415980 @default.
- W3005354171 creator A5027249460 @default.
- W3005354171 creator A5029409018 @default.
- W3005354171 creator A5055417706 @default.
- W3005354171 creator A5062751124 @default.
- W3005354171 creator A5069988423 @default.
- W3005354171 creator A5071269667 @default.
- W3005354171 date "2020-01-01" @default.
- W3005354171 modified "2023-10-04" @default.
- W3005354171 title "lncRNA ROR Promotes Gastric Cancer Drug Resistance" @default.
- W3005354171 cites W1875373156 @default.
- W3005354171 cites W1968972130 @default.
- W3005354171 cites W1995394695 @default.
- W3005354171 cites W2096258216 @default.
- W3005354171 cites W2102209813 @default.
- W3005354171 cites W2133176268 @default.
- W3005354171 cites W2133511259 @default.
- W3005354171 cites W2144269285 @default.
- W3005354171 cites W2155603822 @default.
- W3005354171 cites W2166244362 @default.
- W3005354171 cites W2228507732 @default.
- W3005354171 cites W2272984102 @default.
- W3005354171 cites W2283097883 @default.
- W3005354171 cites W2288185803 @default.
- W3005354171 cites W2403098082 @default.
- W3005354171 cites W2520822567 @default.
- W3005354171 cites W2528288633 @default.
- W3005354171 cites W2542254602 @default.
- W3005354171 cites W2611768639 @default.
- W3005354171 cites W2735126203 @default.
- W3005354171 cites W2758101644 @default.
- W3005354171 cites W2773438931 @default.
- W3005354171 cites W2779162524 @default.
- W3005354171 cites W2780392302 @default.
- W3005354171 cites W2782850057 @default.
- W3005354171 cites W2789425258 @default.
- W3005354171 cites W2790085226 @default.
- W3005354171 cites W2790457313 @default.
- W3005354171 cites W2792745082 @default.
- W3005354171 cites W2794015428 @default.
- W3005354171 cites W2794227107 @default.
- W3005354171 cites W2810642714 @default.
- W3005354171 cites W2886690891 @default.
- W3005354171 cites W2899567541 @default.
- W3005354171 cites W2965026578 @default.
- W3005354171 cites W2969254388 @default.
- W3005354171 cites W3024642074 @default.
- W3005354171 cites W336701656 @default.
- W3005354171 doi "https://doi.org/10.1177/1073274820904694" @default.
- W3005354171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7003177" @default.
- W3005354171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32019330" @default.
- W3005354171 hasPublicationYear "2020" @default.
- W3005354171 type Work @default.
- W3005354171 sameAs 3005354171 @default.
- W3005354171 citedByCount "26" @default.
- W3005354171 countsByYear W30053541712020 @default.
- W3005354171 countsByYear W30053541712021 @default.
- W3005354171 countsByYear W30053541712022 @default.
- W3005354171 countsByYear W30053541712023 @default.
- W3005354171 crossrefType "journal-article" @default.
- W3005354171 hasAuthorship W3005354171A5003715754 @default.
- W3005354171 hasAuthorship W3005354171A5006901857 @default.
- W3005354171 hasAuthorship W3005354171A5014626837 @default.
- W3005354171 hasAuthorship W3005354171A5019415980 @default.
- W3005354171 hasAuthorship W3005354171A5027249460 @default.
- W3005354171 hasAuthorship W3005354171A5029409018 @default.
- W3005354171 hasAuthorship W3005354171A5055417706 @default.
- W3005354171 hasAuthorship W3005354171A5062751124 @default.
- W3005354171 hasAuthorship W3005354171A5069988423 @default.
- W3005354171 hasAuthorship W3005354171A5071269667 @default.
- W3005354171 hasBestOaLocation W30053541711 @default.
- W3005354171 hasConcept C114851261 @default.
- W3005354171 hasConcept C121608353 @default.
- W3005354171 hasConcept C126322002 @default.
- W3005354171 hasConcept C133936738 @default.
- W3005354171 hasConcept C143998085 @default.
- W3005354171 hasConcept C1491633281 @default.
- W3005354171 hasConcept C190283241 @default.
- W3005354171 hasConcept C203014093 @default.
- W3005354171 hasConcept C2776694085 @default.
- W3005354171 hasConcept C502942594 @default.
- W3005354171 hasConcept C54355233 @default.
- W3005354171 hasConcept C553184892 @default.
- W3005354171 hasConcept C55493867 @default.
- W3005354171 hasConcept C71924100 @default.
- W3005354171 hasConcept C77255625 @default.
- W3005354171 hasConcept C86803240 @default.
- W3005354171 hasConcept C89423630 @default.
- W3005354171 hasConcept C96232424 @default.
- W3005354171 hasConcept C98274493 @default.
- W3005354171 hasConceptScore W3005354171C114851261 @default.
- W3005354171 hasConceptScore W3005354171C121608353 @default.
- W3005354171 hasConceptScore W3005354171C126322002 @default.