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• W3005384415 abstract "Abstract In mitosis, the accurate segregation of sister chromosomes relies on kinetochore, a multiple subunits complex assembled on centromere of each sister chromosome. As a core component of inner kinetochore, CENP‐I plays important functions to mediate kinetochore assembly and supports the faithful chromosome segregation. The structures of the N‐terminus and C‐terminus of CENP‐I homologs in complex with CENP‐H/K have been reported, respectively. Unfortunately, the intramolecular interactions of CENP‐I are poorly understood, and how CENP‐I interacts with CENP‐M remains unknown. Here, we verified a unique helix α11, which forms the intramolecular interactions with N‐terminal HEAT repeats in fungal CENP‐I. Deletion of the helix α11 exposed the hydrophobic surface and resulted in the in vitro protein aggregation of N‐terminal HEAT repeats of fungal CENP‐I. The corresponding helix and its intramolecular interaction are highly conserved in human CENP‐I. Deletion of the corresponding helix in human CENP‐I dramatically reduced the functional activity to interact with CENP‐H and CENP‐M. Mutations of the conserved residues on the helix in human CENP‐I significantly weakened the binding to CENP‐M, but not CENP‐H, in HeLa cells. Therefore, our findings for the first time unveiled a conserved helix of CENP‐I, which is important for the intramolecular interaction and function, and would be helpful for understanding the structure basis of how CENP‐I mediates the kinetochore assembly during cell cycle and mitosis." @default.
• W3005384415 created "2020-02-14" @default.
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• W3005384415 date "2020-02-03" @default.
• W3005384415 modified "2023-09-23" @default.
• W3005384415 title "Structural insights into the intramolecular interactions of centromere protein CENP‐I" @default.
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• W3005384415 doi "https://doi.org/10.1002/jmr.2837" @default.
• W3005384415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32017295" @default.
• W3005384415 hasPublicationYear "2020" @default.
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