Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005389576> ?p ?o ?g. }
- W3005389576 endingPage "664" @default.
- W3005389576 startingPage "645" @default.
- W3005389576 abstract "Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA depend on the proper architecture of the mitochondrial membranes and a dynamic remodelling of inner membrane cristae. Defects in mitochondrial architecture can result in severe human diseases affecting predominantly the nervous system and the heart. Inner membrane morphology is generated and maintained in particular by the mitochondrial contact site and cristae organizing system (MICOS), the F1Fo-ATP synthase, the fusion protein OPA1/Mgm1 and the nonbilayer-forming phospholipids cardiolipin and phosphatidylethanolamine. These protein complexes and phospholipids are embedded in a network of functional interactions. They communicate with each other and additional factors, enabling them to balance different aspects of cristae biogenesis and to dynamically remodel the inner mitochondrial membrane. Genetic alterations disturbing these membrane-shaping factors can lead to human pathologies including fatal encephalopathy, dominant optic atrophy, Leigh syndrome, Parkinson's disease and Barth syndrome." @default.
- W3005389576 created "2020-02-14" @default.
- W3005389576 creator A5002461876 @default.
- W3005389576 creator A5014217628 @default.
- W3005389576 creator A5060154627 @default.
- W3005389576 creator A5081737445 @default.
- W3005389576 date "2020-02-26" @default.
- W3005389576 modified "2023-10-10" @default.
- W3005389576 title "Shaping the mitochondrial inner membrane in health and disease" @default.
- W3005389576 cites W1107208185 @default.
- W3005389576 cites W1154539206 @default.
- W3005389576 cites W1569409978 @default.
- W3005389576 cites W1569588368 @default.
- W3005389576 cites W1804633940 @default.
- W3005389576 cites W1852666210 @default.
- W3005389576 cites W1860184706 @default.
- W3005389576 cites W1932855763 @default.
- W3005389576 cites W1964654025 @default.
- W3005389576 cites W1966665626 @default.
- W3005389576 cites W1967445833 @default.
- W3005389576 cites W1969662182 @default.
- W3005389576 cites W1970393644 @default.
- W3005389576 cites W1972661072 @default.
- W3005389576 cites W1972666591 @default.
- W3005389576 cites W1972748461 @default.
- W3005389576 cites W1973274378 @default.
- W3005389576 cites W1973925468 @default.
- W3005389576 cites W1975521267 @default.
- W3005389576 cites W1979489548 @default.
- W3005389576 cites W1981761696 @default.
- W3005389576 cites W1983569416 @default.
- W3005389576 cites W1984695384 @default.
- W3005389576 cites W1986477156 @default.
- W3005389576 cites W1990171977 @default.
- W3005389576 cites W1991003837 @default.
- W3005389576 cites W1995262317 @default.
- W3005389576 cites W1995576553 @default.
- W3005389576 cites W1998333201 @default.
- W3005389576 cites W1998870061 @default.
- W3005389576 cites W2001425543 @default.
- W3005389576 cites W2001756549 @default.
- W3005389576 cites W2003797258 @default.
- W3005389576 cites W2005255392 @default.
- W3005389576 cites W2010886694 @default.
- W3005389576 cites W2011614492 @default.
- W3005389576 cites W2013642338 @default.
- W3005389576 cites W2017032119 @default.
- W3005389576 cites W2017898784 @default.
- W3005389576 cites W2020161289 @default.
- W3005389576 cites W2021138475 @default.
- W3005389576 cites W2024335891 @default.
- W3005389576 cites W2024400317 @default.
- W3005389576 cites W2025449918 @default.
- W3005389576 cites W2027702891 @default.
- W3005389576 cites W2029680040 @default.
- W3005389576 cites W2031189145 @default.
- W3005389576 cites W2032179615 @default.
- W3005389576 cites W2032234589 @default.
- W3005389576 cites W2033130282 @default.
- W3005389576 cites W2034872654 @default.
- W3005389576 cites W2035046899 @default.
- W3005389576 cites W2039407069 @default.
- W3005389576 cites W2039413161 @default.
- W3005389576 cites W2039907011 @default.
- W3005389576 cites W2041982853 @default.
- W3005389576 cites W2042183674 @default.
- W3005389576 cites W2044769030 @default.
- W3005389576 cites W2046442704 @default.
- W3005389576 cites W2048824067 @default.
- W3005389576 cites W2049474080 @default.
- W3005389576 cites W2050189794 @default.
- W3005389576 cites W2051342341 @default.
- W3005389576 cites W2056289504 @default.
- W3005389576 cites W2058479880 @default.
- W3005389576 cites W2062488759 @default.
- W3005389576 cites W2069492714 @default.
- W3005389576 cites W2072138640 @default.
- W3005389576 cites W2072735872 @default.
- W3005389576 cites W2074179637 @default.
- W3005389576 cites W2075046972 @default.
- W3005389576 cites W2076256342 @default.
- W3005389576 cites W2079676584 @default.
- W3005389576 cites W2083174706 @default.
- W3005389576 cites W2089780431 @default.
- W3005389576 cites W2090175505 @default.
- W3005389576 cites W2090734611 @default.
- W3005389576 cites W2090866135 @default.
- W3005389576 cites W2091489629 @default.
- W3005389576 cites W2092899472 @default.
- W3005389576 cites W2093226550 @default.
- W3005389576 cites W2093921916 @default.
- W3005389576 cites W2094113524 @default.
- W3005389576 cites W2097892612 @default.
- W3005389576 cites W2098143955 @default.
- W3005389576 cites W2099103099 @default.
- W3005389576 cites W2100617050 @default.
- W3005389576 cites W2101580077 @default.
- W3005389576 cites W2102626915 @default.