FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005395937> ?p ?o ?g. }

• W3005395937 endingPage "793" @default.
• W3005395937 startingPage "784" @default.
• W3005395937 abstract "Intra-arterial administration of an adenovirus serotype 5 (Ad5) vector in a gene therapy trial caused lethal, systemic inflammation in subject 019 with ornithine transcarbamylase deficiency. This unanticipated inflammatory response was absent in another subject receiving the same vector dose and in 16 subjects receiving lower vector doses. We hypothesized that an immune memory to a previous natural adenovirus infection enhanced the immune response to high-dose systemic Ad5 vector, causing the exaggerated immune response in subject 019. To investigate this, we found that rabbit polyclonal sera to Ad5 and pooled human immunoglobulin (Ig) inhibited Ad5 vector transduction of non-immune cells in vitro, but enhanced transduction and activation of human dendritic cells (DCs). Sera from approximately 7% of normal human subjects and 50% of patients treated topically with Ad5 vectors enhanced Ad5 transduction and activation of DCs, apparently from formation of Ig-Ad5 immune complexes and binding to DCs through FcγR. Subject 019’s blood substantially increased Ad5-vector activation of human DC primary cultures at levels exceeding those from normal subjects. Although this study is based on one event in a single subject, the results implicate a pre-existing humoral immune response to Ad5 in the lethal systemic inflammatory response that occurred in subject 019. Intra-arterial administration of an adenovirus serotype 5 (Ad5) vector in a gene therapy trial caused lethal, systemic inflammation in subject 019 with ornithine transcarbamylase deficiency. This unanticipated inflammatory response was absent in another subject receiving the same vector dose and in 16 subjects receiving lower vector doses. We hypothesized that an immune memory to a previous natural adenovirus infection enhanced the immune response to high-dose systemic Ad5 vector, causing the exaggerated immune response in subject 019. To investigate this, we found that rabbit polyclonal sera to Ad5 and pooled human immunoglobulin (Ig) inhibited Ad5 vector transduction of non-immune cells in vitro, but enhanced transduction and activation of human dendritic cells (DCs). Sera from approximately 7% of normal human subjects and 50% of patients treated topically with Ad5 vectors enhanced Ad5 transduction and activation of DCs, apparently from formation of Ig-Ad5 immune complexes and binding to DCs through FcγR. Subject 019’s blood substantially increased Ad5-vector activation of human DC primary cultures at levels exceeding those from normal subjects. Although this study is based on one event in a single subject, the results implicate a pre-existing humoral immune response to Ad5 in the lethal systemic inflammatory response that occurred in subject 019." @default.
• W3005395937 created "2020-02-14" @default.
• W3005395937 creator A5046993622 @default.
• W3005395937 creator A5051344823 @default.
• W3005395937 creator A5055513739 @default.
• W3005395937 date "2020-03-01" @default.
• W3005395937 modified "2023-10-13" @default.
• W3005395937 title "Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial" @default.
• W3005395937 cites W1987723433 @default.
• W3005395937 cites W1988115863 @default.
• W3005395937 cites W1999053786 @default.
• W3005395937 cites W1999089101 @default.
• W3005395937 cites W2002455862 @default.
• W3005395937 cites W2011984976 @default.
• W3005395937 cites W2023307607 @default.
• W3005395937 cites W2032396826 @default.
• W3005395937 cites W2079017842 @default.
• W3005395937 cites W2079087087 @default.
• W3005395937 cites W2088210297 @default.
• W3005395937 cites W2090864647 @default.
• W3005395937 cites W2093424805 @default.
• W3005395937 cites W2097982006 @default.
• W3005395937 cites W2102144534 @default.
• W3005395937 cites W2128108919 @default.
• W3005395937 cites W2163191830 @default.
• W3005395937 cites W2163192616 @default.
• W3005395937 cites W2322606593 @default.
• W3005395937 cites W2741524965 @default.
• W3005395937 cites W2753217443 @default.
• W3005395937 cites W2785806346 @default.
• W3005395937 cites W2786712411 @default.
• W3005395937 cites W2921258921 @default.
• W3005395937 cites W4239159649 @default.
• W3005395937 doi "https://doi.org/10.1016/j.ymthe.2020.01.006" @default.
• W3005395937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7054813" @default.
• W3005395937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32035027" @default.
• W3005395937 hasPublicationYear "2020" @default.
• W3005395937 type Work @default.
• W3005395937 sameAs 3005395937 @default.
• W3005395937 citedByCount "29" @default.
• W3005395937 countsByYear W30053959372020 @default.
• W3005395937 countsByYear W30053959372021 @default.
• W3005395937 countsByYear W30053959372022 @default.
• W3005395937 countsByYear W30053959372023 @default.
• W3005395937 crossrefType "journal-article" @default.
• W3005395937 hasAuthorship W3005395937A5046993622 @default.
• W3005395937 hasAuthorship W3005395937A5051344823 @default.
• W3005395937 hasAuthorship W3005395937A5055513739 @default.
• W3005395937 hasBestOaLocation W30053959371 @default.
• W3005395937 hasConcept C104317684 @default.
• W3005395937 hasConcept C111599444 @default.
• W3005395937 hasConcept C135983454 @default.
• W3005395937 hasConcept C150903083 @default.
• W3005395937 hasConcept C15152581 @default.
• W3005395937 hasConcept C159654299 @default.
• W3005395937 hasConcept C203014093 @default.
• W3005395937 hasConcept C207001950 @default.
• W3005395937 hasConcept C2522874641 @default.
• W3005395937 hasConcept C25938499 @default.
• W3005395937 hasConcept C2776252253 @default.
• W3005395937 hasConcept C2776914184 @default.
• W3005395937 hasConcept C2776954459 @default.
• W3005395937 hasConcept C2781036101 @default.
• W3005395937 hasConcept C32470452 @default.
• W3005395937 hasConcept C40767141 @default.
• W3005395937 hasConcept C55493867 @default.
• W3005395937 hasConcept C71924100 @default.
• W3005395937 hasConcept C86803240 @default.
• W3005395937 hasConcept C8891405 @default.
• W3005395937 hasConcept C956191 @default.
• W3005395937 hasConceptScore W3005395937C104317684 @default.
• W3005395937 hasConceptScore W3005395937C111599444 @default.
• W3005395937 hasConceptScore W3005395937C135983454 @default.
• W3005395937 hasConceptScore W3005395937C150903083 @default.
• W3005395937 hasConceptScore W3005395937C15152581 @default.
• W3005395937 hasConceptScore W3005395937C159654299 @default.
• W3005395937 hasConceptScore W3005395937C203014093 @default.
• W3005395937 hasConceptScore W3005395937C207001950 @default.
• W3005395937 hasConceptScore W3005395937C2522874641 @default.
• W3005395937 hasConceptScore W3005395937C25938499 @default.
• W3005395937 hasConceptScore W3005395937C2776252253 @default.
• W3005395937 hasConceptScore W3005395937C2776914184 @default.
• W3005395937 hasConceptScore W3005395937C2776954459 @default.
• W3005395937 hasConceptScore W3005395937C2781036101 @default.
• W3005395937 hasConceptScore W3005395937C32470452 @default.
• W3005395937 hasConceptScore W3005395937C40767141 @default.
• W3005395937 hasConceptScore W3005395937C55493867 @default.
• W3005395937 hasConceptScore W3005395937C71924100 @default.
• W3005395937 hasConceptScore W3005395937C86803240 @default.
• W3005395937 hasConceptScore W3005395937C8891405 @default.
• W3005395937 hasConceptScore W3005395937C956191 @default.
• W3005395937 hasFunder F4320308609 @default.
• W3005395937 hasFunder F4320332161 @default.
• W3005395937 hasIssue "3" @default.
• W3005395937 hasLocation W30053959371 @default.
• W3005395937 hasLocation W30053959372 @default.
• W3005395937 hasOpenAccess W3005395937 @default.
• W3005395937 hasPrimaryLocation W30053959371 @default.

• next