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• W3005410156 endingPage "1146" @default.
• W3005410156 startingPage "1146" @default.
• W3005410156 abstract "The skeleton adapts to mechanical loading to promote bone formation and remodeling. While most bone cells are involved in mechanosensing, it is well accepted that osteocytes are the principal mechanosensory cells. The osteocyte cell body and processes are surrounded by a fluid-filled space, forming an extensive lacuno-canalicular network. The flow of interstitial fluid is a major stress-related factor that transmits mechanical stimulation to bone cells. The long dendritic processes of osteocytes form a gap junction channel network connecting not only neighboring osteocytes, but also cells on the bone surface, such as osteoblasts and osteoclasts. Mechanosensitive osteocytes also form hemichannels that mediate the communication between the cytoplasmic and extracellular microenvironment. This paper will discuss recent research progress regarding connexin (Cx)-forming gap junctions and hemichannels in osteocytes, osteoblasts, and other bone cells, including those richly expressing Cx43. We will then cover the recent progress regarding the regulation of these channels by mechanical loading and the role of integrins and signals in mediating Cx43 channels, and bone cell function and viability. Finally, we will summarize the recent studies regarding bone responses to mechanical unloading in Cx43 transgenic mouse models. The osteocyte has been perceived as the center of bone remodeling, and connexin channels enriched in osteocytes are a likely major player in meditating the function of bone. Based on numerous studies, connexin channels may present as a potential new therapeutic target in the treatment of bone loss and osteoporosis. This review will primarily focus on Cx43, with some discussion in other connexins expressed in bone cells." @default.
• W3005410156 created "2020-02-14" @default.
• W3005410156 creator A5044916021 @default.
• W3005410156 creator A5050766937 @default.
• W3005410156 creator A5058957988 @default.
• W3005410156 creator A5059835076 @default.
• W3005410156 date "2020-02-09" @default.
• W3005410156 modified "2023-10-05" @default.
• W3005410156 title "The Role of Connexin Channels in the Response of Mechanical Loading and Unloading of Bone" @default.
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• W3005410156 doi "https://doi.org/10.3390/ijms21031146" @default.
• W3005410156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7038207" @default.
• W3005410156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32050469" @default.
• W3005410156 hasPublicationYear "2020" @default.
• W3005410156 type Work @default.
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• W3005410156 hasAuthorship W3005410156A5044916021 @default.
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• W3005410156 hasAuthorship W3005410156A5058957988 @default.
• W3005410156 hasAuthorship W3005410156A5059835076 @default.

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