Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005427864> ?p ?o ?g. }
- W3005427864 abstract "Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three distinct conformations during activation: resting, intermediate, and activated. Experimental determination of the structure of a potassium channel VSD in the intermediate state has previously proven elusive. Here, we report and validate the experimental three-dimensional structure of the human KCNQ1 voltage-gated potassium channel VSD in the intermediate state. We also used mutagenesis and electrophysiology in Xenopus laevisoocytes to functionally map the determinants of S4 helix motion during voltage-dependent transition from the intermediate to the activated state. Finally, the physiological relevance of the intermediate state KCNQ1 conductance is demonstrated using voltage-clamp fluorometry. This work illuminates the structure of the VSD intermediate state and demonstrates that intermediate state conductivity contributes to the unusual versatility of KCNQ1, which can function either as the slow delayed rectifier current (IKs) of the cardiac action potential or as a constitutively active epithelial leak current." @default.
- W3005427864 created "2020-02-14" @default.
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- W3005427864 date "2020-02-25" @default.
- W3005427864 modified "2023-09-27" @default.
- W3005427864 title "Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state" @default.
- W3005427864 cites W1568650538 @default.
- W3005427864 cites W1594345270 @default.
- W3005427864 cites W1668163968 @default.
- W3005427864 cites W1678317167 @default.
- W3005427864 cites W1963525648 @default.
- W3005427864 cites W1965191256 @default.
- W3005427864 cites W1967108876 @default.
- W3005427864 cites W1969302686 @default.
- W3005427864 cites W1979295135 @default.
- W3005427864 cites W1983137097 @default.
- W3005427864 cites W1983519301 @default.
- W3005427864 cites W1983523125 @default.
- W3005427864 cites W1983704513 @default.
- W3005427864 cites W1985582773 @default.
- W3005427864 cites W1987382493 @default.
- W3005427864 cites W1987908892 @default.
- W3005427864 cites W1989585015 @default.
- W3005427864 cites W1989921227 @default.
- W3005427864 cites W1990771438 @default.
- W3005427864 cites W1991139261 @default.
- W3005427864 cites W1994788621 @default.
- W3005427864 cites W1999805574 @default.
- W3005427864 cites W2002422701 @default.
- W3005427864 cites W2003041358 @default.
- W3005427864 cites W2009241113 @default.
- W3005427864 cites W2015448723 @default.
- W3005427864 cites W2025086029 @default.
- W3005427864 cites W2026609572 @default.
- W3005427864 cites W2032734987 @default.
- W3005427864 cites W2038346739 @default.
- W3005427864 cites W2040081725 @default.
- W3005427864 cites W2050306094 @default.
- W3005427864 cites W2052976216 @default.
- W3005427864 cites W2054990961 @default.
- W3005427864 cites W2062543415 @default.
- W3005427864 cites W2063746676 @default.
- W3005427864 cites W2065708189 @default.
- W3005427864 cites W2067930415 @default.
- W3005427864 cites W2077082977 @default.
- W3005427864 cites W2090836923 @default.
- W3005427864 cites W2093768785 @default.
- W3005427864 cites W2094150460 @default.
- W3005427864 cites W2104759180 @default.
- W3005427864 cites W2114192621 @default.
- W3005427864 cites W2116807248 @default.
- W3005427864 cites W2118233996 @default.
- W3005427864 cites W2133719258 @default.
- W3005427864 cites W2133983762 @default.
- W3005427864 cites W2136332525 @default.
- W3005427864 cites W2142833617 @default.
- W3005427864 cites W2144420181 @default.
- W3005427864 cites W2147979587 @default.
- W3005427864 cites W2148521301 @default.
- W3005427864 cites W2154420373 @default.
- W3005427864 cites W2162552811 @default.
- W3005427864 cites W2164829352 @default.
- W3005427864 cites W2167785149 @default.
- W3005427864 cites W2177346140 @default.
- W3005427864 cites W2202507358 @default.
- W3005427864 cites W2279211181 @default.
- W3005427864 cites W2293843772 @default.
- W3005427864 cites W2297394102 @default.
- W3005427864 cites W2323104785 @default.
- W3005427864 cites W2483708666 @default.
- W3005427864 cites W2515540061 @default.
- W3005427864 cites W2548502736 @default.
- W3005427864 cites W2567731798 @default.
- W3005427864 cites W2576780822 @default.
- W3005427864 cites W2584864481 @default.
- W3005427864 cites W2606438863 @default.
- W3005427864 cites W2620982682 @default.
- W3005427864 cites W2763402483 @default.
- W3005427864 cites W2768927592 @default.
- W3005427864 cites W2770914482 @default.
- W3005427864 cites W2784198595 @default.
- W3005427864 cites W2883159493 @default.
- W3005427864 cites W2911906719 @default.
- W3005427864 cites W2912960734 @default.
- W3005427864 cites W2946192592 @default.
- W3005427864 cites W2951265935 @default.