FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005431202> ?p ?o ?g. }

• W3005431202 endingPage "1716" @default.
• W3005431202 startingPage "1701" @default.
• W3005431202 abstract "Background and aims: Untreated portopulmonary hypertension (PoPH) carries a poor prognosis. Previous reports have described vasomodulator (VM) therapy and liver transplantation (LT) as treatment options. We aimed to provide summary estimates on the endpoints of pulmonary hemodynamics and survival in patients with PoPH, treated with different modalities.Approach and results: We performed a systematic review with meta-analysis of mainly observational and case-control studies describing no treatment, VM, LT, or VM + LT in patients with PoPH. Twenty-six studies (1,019 patients) were included. Both VM and VM + LT improve pulmonary hemodynamics. A substantial proportion of patients treated with VM become eligible for LT (44%; 95% confidence interval [CI], 31-58). Pooled estimates for 1-, and 3-year postdiagnosis survival in patients treated with VM were 86% (95% CI, 81-90) and 69% (95% CI, 50-84) versus 82% (95% CI, 52-95) and 67% (95% CI, 53-78) in patients treated with VM + LT. Of note, studies reporting on the effect of VM mainly included Child-Pugh A/B patients, whereas studies reporting on VM + LT mainly included Child-Pugh B/C. Seven studies (238 patients) included both patients who received VM only and patients who received VM + LT. Risk of death in VM-only-treated patients was significantly higher than in patients who could be transplanted as well (odds ratio, 3.5; 95% CI, 1.4-8.8); however, importantly, patients who proceeded to transplant had been selected very strictly. In 50% of patients, VM can be discontinued post-LT (95% CI, 38-62).Conclusions: VM and VM + LT both improve pulmonary hemodynamics and prognosis in PoPH. In a strictly selected subpopulation of cases where LT is indicated based on severe liver disease and where LT is considered safe and feasible, treatment with VM + LT confers a better prognosis. Considering successful VM, 44% can proceed to LT, with half being able to postoperatively stop medication." @default.
• W3005431202 created "2020-02-14" @default.
• W3005431202 creator A5006812658 @default.
• W3005431202 creator A5008360462 @default.
• W3005431202 creator A5016615128 @default.
• W3005431202 creator A5034165489 @default.
• W3005431202 creator A5034858752 @default.
• W3005431202 creator A5051854606 @default.
• W3005431202 creator A5058513233 @default.
• W3005431202 creator A5064991543 @default.
• W3005431202 creator A5072950514 @default.
• W3005431202 creator A5087989756 @default.
• W3005431202 date "2020-10-19" @default.
• W3005431202 modified "2023-09-23" @default.
• W3005431202 title "Vasomodulators and Liver Transplantation for Portopulmonary Hypertension: Evidence From a Systematic Review and Meta‐Analysis" @default.
• W3005431202 cites W1025097961 @default.
• W3005431202 cites W1505295239 @default.
• W3005431202 cites W1904628406 @default.
• W3005431202 cites W1964435302 @default.
• W3005431202 cites W1967321784 @default.
• W3005431202 cites W1979423827 @default.
• W3005431202 cites W1986915843 @default.
• W3005431202 cites W2004588259 @default.
• W3005431202 cites W2013088455 @default.
• W3005431202 cites W2019985521 @default.
• W3005431202 cites W2020874914 @default.
• W3005431202 cites W2026687293 @default.
• W3005431202 cites W2028467903 @default.
• W3005431202 cites W2037473973 @default.
• W3005431202 cites W2046370050 @default.
• W3005431202 cites W2054350373 @default.
• W3005431202 cites W2061353071 @default.
• W3005431202 cites W2069727305 @default.
• W3005431202 cites W2071673615 @default.
• W3005431202 cites W2077664306 @default.
• W3005431202 cites W2079531583 @default.
• W3005431202 cites W2087200272 @default.
• W3005431202 cites W2126930838 @default.
• W3005431202 cites W2141898868 @default.
• W3005431202 cites W2150922388 @default.
• W3005431202 cites W2152488221 @default.
• W3005431202 cites W2157759364 @default.
• W3005431202 cites W2312396238 @default.
• W3005431202 cites W2462011129 @default.
• W3005431202 cites W2514149649 @default.
• W3005431202 cites W2529035077 @default.
• W3005431202 cites W2532093941 @default.
• W3005431202 cites W2562604261 @default.
• W3005431202 cites W2567617340 @default.
• W3005431202 cites W2766580305 @default.
• W3005431202 cites W2917632902 @default.
• W3005431202 cites W2948867885 @default.
• W3005431202 cites W4249775406 @default.
• W3005431202 doi "https://doi.org/10.1002/hep.31164" @default.
• W3005431202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32017176" @default.
• W3005431202 hasPublicationYear "2020" @default.
• W3005431202 type Work @default.
• W3005431202 sameAs 3005431202 @default.
• W3005431202 citedByCount "24" @default.
• W3005431202 countsByYear W30054312022020 @default.
• W3005431202 countsByYear W30054312022021 @default.
• W3005431202 countsByYear W30054312022022 @default.
• W3005431202 countsByYear W30054312022023 @default.
• W3005431202 crossrefType "journal-article" @default.
• W3005431202 hasAuthorship W3005431202A5006812658 @default.
• W3005431202 hasAuthorship W3005431202A5008360462 @default.
• W3005431202 hasAuthorship W3005431202A5016615128 @default.
• W3005431202 hasAuthorship W3005431202A5034165489 @default.
• W3005431202 hasAuthorship W3005431202A5034858752 @default.
• W3005431202 hasAuthorship W3005431202A5051854606 @default.
• W3005431202 hasAuthorship W3005431202A5058513233 @default.
• W3005431202 hasAuthorship W3005431202A5064991543 @default.
• W3005431202 hasAuthorship W3005431202A5072950514 @default.
• W3005431202 hasAuthorship W3005431202A5087989756 @default.
• W3005431202 hasConcept C126322002 @default.
• W3005431202 hasConcept C2777728312 @default.
• W3005431202 hasConcept C2779609443 @default.
• W3005431202 hasConcept C2911091166 @default.
• W3005431202 hasConcept C71924100 @default.
• W3005431202 hasConcept C90924648 @default.
• W3005431202 hasConcept C95190672 @default.
• W3005431202 hasConceptScore W3005431202C126322002 @default.
• W3005431202 hasConceptScore W3005431202C2777728312 @default.
• W3005431202 hasConceptScore W3005431202C2779609443 @default.
• W3005431202 hasConceptScore W3005431202C2911091166 @default.
• W3005431202 hasConceptScore W3005431202C71924100 @default.
• W3005431202 hasConceptScore W3005431202C90924648 @default.
• W3005431202 hasConceptScore W3005431202C95190672 @default.
• W3005431202 hasFunder F4320321390 @default.
• W3005431202 hasFunder F4320321730 @default.
• W3005431202 hasIssue "5" @default.
• W3005431202 hasLocation W30054312021 @default.
• W3005431202 hasOpenAccess W3005431202 @default.
• W3005431202 hasPrimaryLocation W30054312021 @default.
• W3005431202 hasRelatedWork W2000354798 @default.
• W3005431202 hasRelatedWork W2001108929 @default.
• W3005431202 hasRelatedWork W2007072710 @default.
• W3005431202 hasRelatedWork W2016298423 @default.

• next