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- W3005466151 abstract "Heart rhythms are governed by the sinoatrial node pacemaker, where a stimulus travels downwards until it reaches the ventricles, allowing for proper muscle contraction. However, tissue damage such as scars and/or blocks can affect wave propagation, resulting in parameter changes such as conduction velocity and periodicity, thus facilitating the rise of arrhythmic behaviors. We have optically introduced an area of block onto ventricular monolayers and successfully controlled its behavior, finding an inherent relationship between the region of block and the refractoriness of surrounding tissue that is still able to trigger an action potential and propagate. The observed changes in wave propagation resulted in interesting dynamics, such as increased period, conduction velocity, and arrhythmogenesis. It is well known that perturbations to heart rhythm can precipitate the arise of cardiac pathologies depending on the affected area. Important factors such as timing and tissue refractoriness are crucial for the initiation or termination of these behaviors. Here, we provide a 2-dimensional system that allows for the deeper investigation of arrhythmic dynamics, introducing removable areas of block using optogenetics. These blocks can be correlated to tissue scarring, death cell patches, among others, and provide fundamental knowledge as to how current treatments like cardiac ablation could worsen the patient outcome if the scar location would propitiate the observed reentry geometries." @default.
- W3005466151 created "2020-02-14" @default.
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- W3005466151 date "2020-02-01" @default.
- W3005466151 modified "2023-09-26" @default.
- W3005466151 title "Unidirectional Block Demonstrated on Ventricular Monolayers Expressing Channelrhodopsin-2 using Optogenetics" @default.
- W3005466151 doi "https://doi.org/10.1016/j.bpj.2019.11.3103" @default.
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