Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005469503> ?p ?o ?g. }
- W3005469503 endingPage "271" @default.
- W3005469503 startingPage "255" @default.
- W3005469503 abstract "This article reassesses historical studies of Inuit metabolism in light of recent developments in evolutionary genetics. It discusses the possible selective advantage of a variant of CPT1a, which encodes the rate limiting enzyme in hepatic fatty acid oxidation. The L479 variant of CPT1a underwent one of the strongest known selective sweeps in human history and is specific to Inuit and Yu'pik populations. Recent hypotheses predict that this variant may have been selected in response to possible detrimental effects of chronic ketosis in communities with very low carbohydrate consumption. Assessing these hypotheses alongside several alternative explanations of the selective sweep, this article challenges the notion that the selection of L479 is linked to predicted detrimental effects of ketosis. Bringing together for the first time data from biochemical, metabolic, and physiological studies inside and outside the Inuit sphere, it aims to provide a broader interpretative framework and a more comprehensive way to understand the selective sweep. It suggests that L479 may have provided a selective advantage in glucose conservation as part of a metabolic adaptation to very low carbohydrate and high protein consumption, but not necessarily a ketogenic state, in an extremely cold environment. A high intake of n-3 fatty acids may be linked to selection through the mitigation of a detrimental effect of the mutation that arises in the fasted state. The implications of these conclusions for our broader understanding of very low carbohydrate metabolism, and for dietary recommendations for Inuit and non-Inuit populations, are discussed." @default.
- W3005469503 created "2020-02-14" @default.
- W3005469503 creator A5035899252 @default.
- W3005469503 date "2020-04-01" @default.
- W3005469503 modified "2023-10-04" @default.
- W3005469503 title "Inuit metabolism revisited: what drove the selective sweep of CPT1a L479?" @default.
- W3005469503 cites W146385722 @default.
- W3005469503 cites W1494515526 @default.
- W3005469503 cites W1497309672 @default.
- W3005469503 cites W1503760388 @default.
- W3005469503 cites W1539346336 @default.
- W3005469503 cites W1606501470 @default.
- W3005469503 cites W1641669431 @default.
- W3005469503 cites W174837603 @default.
- W3005469503 cites W181745290 @default.
- W3005469503 cites W1825737355 @default.
- W3005469503 cites W1834303186 @default.
- W3005469503 cites W1935406405 @default.
- W3005469503 cites W1947801417 @default.
- W3005469503 cites W1949746942 @default.
- W3005469503 cites W1965873425 @default.
- W3005469503 cites W1972072909 @default.
- W3005469503 cites W1975334244 @default.
- W3005469503 cites W1975693364 @default.
- W3005469503 cites W1976229622 @default.
- W3005469503 cites W1977280433 @default.
- W3005469503 cites W1978097060 @default.
- W3005469503 cites W1987196183 @default.
- W3005469503 cites W1987599783 @default.
- W3005469503 cites W1992146473 @default.
- W3005469503 cites W1994348637 @default.
- W3005469503 cites W1994622971 @default.
- W3005469503 cites W1994665344 @default.
- W3005469503 cites W1996248962 @default.
- W3005469503 cites W1996417919 @default.
- W3005469503 cites W1999656763 @default.
- W3005469503 cites W2000349524 @default.
- W3005469503 cites W2000840225 @default.
- W3005469503 cites W2001220657 @default.
- W3005469503 cites W2001513552 @default.
- W3005469503 cites W2002236420 @default.
- W3005469503 cites W2005827500 @default.
- W3005469503 cites W2005939151 @default.
- W3005469503 cites W2010837230 @default.
- W3005469503 cites W2019671343 @default.
- W3005469503 cites W2020197846 @default.
- W3005469503 cites W2026323479 @default.
- W3005469503 cites W2029252610 @default.
- W3005469503 cites W2029460748 @default.
- W3005469503 cites W2029733532 @default.
- W3005469503 cites W2031846075 @default.
- W3005469503 cites W2038584209 @default.
- W3005469503 cites W2039186065 @default.
- W3005469503 cites W2039621964 @default.
- W3005469503 cites W2040328785 @default.
- W3005469503 cites W2042827948 @default.
- W3005469503 cites W2044741373 @default.
- W3005469503 cites W2044949234 @default.
- W3005469503 cites W2045656711 @default.
- W3005469503 cites W2047399305 @default.
- W3005469503 cites W2048594700 @default.
- W3005469503 cites W2062006752 @default.
- W3005469503 cites W2063717110 @default.
- W3005469503 cites W2067652301 @default.
- W3005469503 cites W2068226015 @default.
- W3005469503 cites W2069193149 @default.
- W3005469503 cites W2070613104 @default.
- W3005469503 cites W2071301127 @default.
- W3005469503 cites W2072139782 @default.
- W3005469503 cites W2076129201 @default.
- W3005469503 cites W2077132863 @default.
- W3005469503 cites W2080315023 @default.
- W3005469503 cites W2089841034 @default.
- W3005469503 cites W2091700443 @default.
- W3005469503 cites W2095471147 @default.
- W3005469503 cites W2096998782 @default.
- W3005469503 cites W2098457930 @default.
- W3005469503 cites W2098583905 @default.
- W3005469503 cites W2099021002 @default.
- W3005469503 cites W2100023355 @default.
- W3005469503 cites W2103185950 @default.
- W3005469503 cites W2104938317 @default.
- W3005469503 cites W2105597558 @default.
- W3005469503 cites W2106258006 @default.
- W3005469503 cites W2106970085 @default.
- W3005469503 cites W2111254673 @default.
- W3005469503 cites W2115366040 @default.
- W3005469503 cites W2116921200 @default.
- W3005469503 cites W2118124249 @default.
- W3005469503 cites W2119901011 @default.
- W3005469503 cites W2120313579 @default.
- W3005469503 cites W2125110604 @default.
- W3005469503 cites W2125222784 @default.
- W3005469503 cites W2127812547 @default.
- W3005469503 cites W2128264631 @default.
- W3005469503 cites W2129398780 @default.
- W3005469503 cites W2131698027 @default.
- W3005469503 cites W2137855436 @default.