FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005537664> ?p ?o ?g. }

• W3005537664 endingPage "109" @default.
• W3005537664 startingPage "109" @default.
• W3005537664 abstract "Dinoflagellates, a major class of marine eukaryote microalgae composing the phytoplankton, are widely recognised as producers of a large variety of toxic molecules, particularly neurotoxins, which can also act as potent bioactive pharmacological mediators. In addition, similarly to other microalgae, they are also good producers of polyunsaturated fatty acids (PUFAs), important precursors of key molecules involved in cell physiology. Among PUFA derivatives are the prostaglandins (Pgs), important physiological mediators in several physiological and pathological processes in humans, also used as biological drugs. Their synthesis is very expensive because of the elevated number of reaction steps required, thus the search for new Pgs production methods is of great relevance. One possibility is their extraction from microorganisms (e.g., diatoms), which have been proved to produce the same Pgs as humans. In the present study, we took advantage of the available transcriptomes for dinoflagellates in the iMicrobe database to search for the Pgs biosynthetic pathway using a bioinformatic approach. Here we show that dinoflagellates express nine Pg-metabolism related enzymes involved in both Pgs synthesis and reduction. Not all of the enzymes were expressed simultaneously in all the species analysed and their expression was influenced by culturing conditions, especially salinity of the growth medium. These results confirm the existence of a biosynthetic pathway for these important molecules in unicellular microalgae other than diatoms, suggesting a broad diffusion and conservation of the Pgs pathway, which further strengthen their importance in living organisms." @default.
• W3005537664 created "2020-02-24" @default.
• W3005537664 creator A5045095995 @default.
• W3005537664 creator A5059309264 @default.
• W3005537664 creator A5089697692 @default.
• W3005537664 date "2020-02-13" @default.
• W3005537664 modified "2023-10-17" @default.
• W3005537664 title "Identification of Prostaglandin Pathway in Dinoflagellates by Transcriptome Data Mining" @default.
• W3005537664 cites W1139957301 @default.
• W3005537664 cites W1527815065 @default.
• W3005537664 cites W1978907270 @default.
• W3005537664 cites W1983769980 @default.
• W3005537664 cites W1986989621 @default.
• W3005537664 cites W1995993324 @default.
• W3005537664 cites W2019619926 @default.
• W3005537664 cites W2030544803 @default.
• W3005537664 cites W2030593953 @default.
• W3005537664 cites W2047307794 @default.
• W3005537664 cites W2047319374 @default.
• W3005537664 cites W2055650596 @default.
• W3005537664 cites W2057797585 @default.
• W3005537664 cites W2058608211 @default.
• W3005537664 cites W2059311051 @default.
• W3005537664 cites W2063906821 @default.
• W3005537664 cites W2068258498 @default.
• W3005537664 cites W2074017039 @default.
• W3005537664 cites W2078588075 @default.
• W3005537664 cites W2087470395 @default.
• W3005537664 cites W2087736560 @default.
• W3005537664 cites W2125223812 @default.
• W3005537664 cites W2243973902 @default.
• W3005537664 cites W2341500339 @default.
• W3005537664 cites W2600304110 @default.
• W3005537664 cites W2606991824 @default.
• W3005537664 cites W2734052370 @default.
• W3005537664 cites W2754640555 @default.
• W3005537664 cites W2775877335 @default.
• W3005537664 cites W2891440776 @default.
• W3005537664 cites W2918580604 @default.
• W3005537664 cites W2938100409 @default.
• W3005537664 cites W2955804539 @default.
• W3005537664 cites W2957760723 @default.
• W3005537664 cites W2964052848 @default.
• W3005537664 cites W4211061702 @default.
• W3005537664 doi "https://doi.org/10.3390/md18020109" @default.
• W3005537664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7073720" @default.
• W3005537664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32069885" @default.
• W3005537664 hasPublicationYear "2020" @default.
• W3005537664 type Work @default.
• W3005537664 sameAs 3005537664 @default.
• W3005537664 citedByCount "4" @default.
• W3005537664 countsByYear W30055376642020 @default.
• W3005537664 countsByYear W30055376642021 @default.
• W3005537664 countsByYear W30055376642022 @default.
• W3005537664 crossrefType "journal-article" @default.
• W3005537664 hasAuthorship W3005537664A5045095995 @default.
• W3005537664 hasAuthorship W3005537664A5059309264 @default.
• W3005537664 hasAuthorship W3005537664A5089697692 @default.
• W3005537664 hasBestOaLocation W30055376641 @default.
• W3005537664 hasConcept C104317684 @default.
• W3005537664 hasConcept C141231307 @default.
• W3005537664 hasConcept C150194340 @default.
• W3005537664 hasConcept C162317418 @default.
• W3005537664 hasConcept C181199279 @default.
• W3005537664 hasConcept C19038510 @default.
• W3005537664 hasConcept C192989942 @default.
• W3005537664 hasConcept C2778760044 @default.
• W3005537664 hasConcept C2779413310 @default.
• W3005537664 hasConcept C543025807 @default.
• W3005537664 hasConcept C55493867 @default.
• W3005537664 hasConcept C559758991 @default.
• W3005537664 hasConcept C59822182 @default.
• W3005537664 hasConcept C86803240 @default.
• W3005537664 hasConceptScore W3005537664C104317684 @default.
• W3005537664 hasConceptScore W3005537664C141231307 @default.
• W3005537664 hasConceptScore W3005537664C150194340 @default.
• W3005537664 hasConceptScore W3005537664C162317418 @default.
• W3005537664 hasConceptScore W3005537664C181199279 @default.
• W3005537664 hasConceptScore W3005537664C19038510 @default.
• W3005537664 hasConceptScore W3005537664C192989942 @default.
• W3005537664 hasConceptScore W3005537664C2778760044 @default.
• W3005537664 hasConceptScore W3005537664C2779413310 @default.
• W3005537664 hasConceptScore W3005537664C543025807 @default.
• W3005537664 hasConceptScore W3005537664C55493867 @default.
• W3005537664 hasConceptScore W3005537664C559758991 @default.
• W3005537664 hasConceptScore W3005537664C59822182 @default.
• W3005537664 hasConceptScore W3005537664C86803240 @default.
• W3005537664 hasFunder F4320322218 @default.
• W3005537664 hasFunder F4320326431 @default.
• W3005537664 hasIssue "2" @default.
• W3005537664 hasLocation W30055376641 @default.
• W3005537664 hasLocation W30055376642 @default.
• W3005537664 hasLocation W30055376643 @default.
• W3005537664 hasLocation W30055376644 @default.
• W3005537664 hasLocation W30055376645 @default.
• W3005537664 hasOpenAccess W3005537664 @default.
• W3005537664 hasPrimaryLocation W30055376641 @default.
• W3005537664 hasRelatedWork W1581350964 @default.

• next