Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005553386> ?p ?o ?g. }
- W3005553386 endingPage "358" @default.
- W3005553386 startingPage "350" @default.
- W3005553386 abstract "Background: Acute hemorrhage, both traumatic and nontraumatic, leads to significant morbidity and mortality, both in the United States and globally. Traditional treatment of acute hemorrhage is focused on hemostasis and blood product replacement. Tranexamic acid is an antifibrinolytic agent that may reduce acute hemorrhage through inhibition of plasminogen. Newer research suggests that coagulopathy, specifically fibrinolysis, may contribute significantly to the pathology of acute hemorrhage. Methods: We searched the PubMed database for relevant articles from 2000 to 2018 for the terms “tranexamic acid,” “TXA,” “antifibrinolytic,” “hyperfibrinolysis,” and “coagulopathy.” Our search was limited to studies published in the English language. Results: A total of 53 studies were included in this review. These articles suggest a potential role for tranexamic acid in the management of acute intracranial hemorrhage, epistaxis, hematuria, postpartum hemorrhage, gastrointestinal hemorrhage, and trauma-related hemorrhage. A theoretical risk of thrombotic events following tranexamic acid use exists, though large clinical trials suggest this risk remains exceedingly small. Conclusions: Recent studies suggest a mortality benefit with tranexamic acid following acute hemorrhage. First responders such as emergency medical technicians and emergency department clinicians should consider tranexamic acid as an adjunct therapy in the management of acute, severe traumatic and nontraumatic hemorrhage." @default.
- W3005553386 created "2020-02-24" @default.
- W3005553386 creator A5012811691 @default.
- W3005553386 creator A5034791071 @default.
- W3005553386 creator A5062731260 @default.
- W3005553386 creator A5086545738 @default.
- W3005553386 date "2020-02-13" @default.
- W3005553386 modified "2023-09-29" @default.
- W3005553386 title "The Role of Tranexamic Acid in the Management of an Acutely Hemorrhaging Patient" @default.
- W3005553386 cites W1482884854 @default.
- W3005553386 cites W1549647476 @default.
- W3005553386 cites W1626738737 @default.
- W3005553386 cites W1964392896 @default.
- W3005553386 cites W1991764167 @default.
- W3005553386 cites W2001225605 @default.
- W3005553386 cites W2028627947 @default.
- W3005553386 cites W2029829108 @default.
- W3005553386 cites W2031433694 @default.
- W3005553386 cites W2041776536 @default.
- W3005553386 cites W2058865836 @default.
- W3005553386 cites W2066320077 @default.
- W3005553386 cites W2066352637 @default.
- W3005553386 cites W2068966326 @default.
- W3005553386 cites W2075182040 @default.
- W3005553386 cites W2084654416 @default.
- W3005553386 cites W2103984846 @default.
- W3005553386 cites W2111548427 @default.
- W3005553386 cites W2117051337 @default.
- W3005553386 cites W2125149930 @default.
- W3005553386 cites W2134219545 @default.
- W3005553386 cites W2136587148 @default.
- W3005553386 cites W2148920758 @default.
- W3005553386 cites W2156125313 @default.
- W3005553386 cites W2159468828 @default.
- W3005553386 cites W2159561976 @default.
- W3005553386 cites W2161206101 @default.
- W3005553386 cites W2162249417 @default.
- W3005553386 cites W2166087271 @default.
- W3005553386 cites W2171109226 @default.
- W3005553386 cites W2174657578 @default.
- W3005553386 cites W2313048660 @default.
- W3005553386 cites W2410951383 @default.
- W3005553386 cites W2507044693 @default.
- W3005553386 cites W2554678135 @default.
- W3005553386 cites W2605806871 @default.
- W3005553386 cites W2607870311 @default.
- W3005553386 cites W2618028107 @default.
- W3005553386 cites W2623312837 @default.
- W3005553386 cites W2745687726 @default.
- W3005553386 cites W2753584628 @default.
- W3005553386 cites W2766227121 @default.
- W3005553386 cites W2767208517 @default.
- W3005553386 cites W2768018286 @default.
- W3005553386 cites W2774819407 @default.
- W3005553386 cites W2790324064 @default.
- W3005553386 cites W2795703779 @default.
- W3005553386 cites W2801169255 @default.
- W3005553386 cites W2804714053 @default.
- W3005553386 cites W2806097108 @default.
- W3005553386 cites W2887251061 @default.
- W3005553386 cites W2888124739 @default.
- W3005553386 cites W2892797083 @default.
- W3005553386 cites W2893826425 @default.
- W3005553386 cites W2895736881 @default.
- W3005553386 cites W2907707966 @default.
- W3005553386 cites W2911929055 @default.
- W3005553386 cites W2915299432 @default.
- W3005553386 cites W2932080593 @default.
- W3005553386 cites W4210545799 @default.
- W3005553386 cites W4211043869 @default.
- W3005553386 cites W4233741605 @default.
- W3005553386 cites W4237817546 @default.
- W3005553386 cites W998878796 @default.
- W3005553386 doi "https://doi.org/10.1177/0018578720906613" @default.
- W3005553386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8326847" @default.
- W3005553386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34381274" @default.
- W3005553386 hasPublicationYear "2020" @default.
- W3005553386 type Work @default.
- W3005553386 sameAs 3005553386 @default.
- W3005553386 citedByCount "3" @default.
- W3005553386 countsByYear W30055533862022 @default.
- W3005553386 countsByYear W30055533862023 @default.
- W3005553386 crossrefType "journal-article" @default.
- W3005553386 hasAuthorship W3005553386A5012811691 @default.
- W3005553386 hasAuthorship W3005553386A5034791071 @default.
- W3005553386 hasAuthorship W3005553386A5062731260 @default.
- W3005553386 hasAuthorship W3005553386A5086545738 @default.
- W3005553386 hasBestOaLocation W30055533862 @default.
- W3005553386 hasConcept C126322002 @default.
- W3005553386 hasConcept C141071460 @default.
- W3005553386 hasConcept C177713679 @default.
- W3005553386 hasConcept C2776825266 @default.
- W3005553386 hasConcept C2777278314 @default.
- W3005553386 hasConcept C2778589496 @default.
- W3005553386 hasConcept C2779637338 @default.
- W3005553386 hasConcept C2779936836 @default.
- W3005553386 hasConcept C2781219028 @default.
- W3005553386 hasConcept C2781436528 @default.