FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005555877> ?p ?o ?g. }

• W3005555877 endingPage "110253" @default.
• W3005555877 startingPage "110253" @default.
• W3005555877 abstract "Silica particles can cause a systemic disease in workers termed lung silicosis, characterized by diffuse fibrosis. The development of lung silicosis involves various signaling pathway networks comprising numerous cell types and cytokines. As an important medium for communication between cells, exosomes have emerged as a hot research topic; however, the role of exosomal microRNAs (miRNAs) in silicosis remains unclear. In this study, we conducted high-throughput sequencing to generate exosomal miRNAs profiles from macrophages that were either exposed to silica or not. A total of 298 miRNAs were differentially expressed, with 155 up-regulated and 143 down-regulated. Highly conserved differentially expressed miRNAs were functionally annotated and analyzed to predict target genes. Among target interactions associated with the TGF-β signaling pathway, miR-125a-5p and its putative target gene, Smurf1, were subjected to further research. As expected, levels of miR-125a-5p were upregulated in human serous exosomes and vitro, and inhibit the exosomal miR-125a-5p suppressed the expression of the fibrosis hallmarks. Besides, high levels of the miRNA led to upregulation of smooth muscle actin alpha and repression of Smurf1 in NIH-3T3 and MRC-5 cells. ID1 and SMAD1, downstream of TGF-β signaling, were upregulated, indicating potential activation of this signaling pathway. These results contribute to understanding of the intercellular communication mediated by exosomal miRNAs and its critical role in fibroblast to myofibroblast transition and silicosis." @default.
• W3005555877 created "2020-02-24" @default.
• W3005555877 creator A5001530911 @default.
• W3005555877 creator A5017865884 @default.
• W3005555877 creator A5021541475 @default.
• W3005555877 creator A5030492984 @default.
• W3005555877 creator A5038524964 @default.
• W3005555877 creator A5042524516 @default.
• W3005555877 creator A5052304130 @default.
• W3005555877 creator A5067582026 @default.
• W3005555877 creator A5074702615 @default.
• W3005555877 creator A5087798833 @default.
• W3005555877 creator A5088076863 @default.
• W3005555877 date "2020-04-01" @default.
• W3005555877 modified "2023-10-02" @default.
• W3005555877 title "Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation" @default.
• W3005555877 cites W1572233670 @default.
• W3005555877 cites W1762620449 @default.
• W3005555877 cites W1877686344 @default.
• W3005555877 cites W1924766357 @default.
• W3005555877 cites W1987409881 @default.
• W3005555877 cites W1999925406 @default.
• W3005555877 cites W2015851393 @default.
• W3005555877 cites W2029897223 @default.
• W3005555877 cites W2030701238 @default.
• W3005555877 cites W2047960154 @default.
• W3005555877 cites W2074078019 @default.
• W3005555877 cites W2081229292 @default.
• W3005555877 cites W2083843591 @default.
• W3005555877 cites W2087467372 @default.
• W3005555877 cites W2158330587 @default.
• W3005555877 cites W2169465106 @default.
• W3005555877 cites W2273372601 @default.
• W3005555877 cites W2301890235 @default.
• W3005555877 cites W2338671470 @default.
• W3005555877 cites W2405705091 @default.
• W3005555877 cites W2465241170 @default.
• W3005555877 cites W2569777176 @default.
• W3005555877 cites W2588427896 @default.
• W3005555877 cites W2742567781 @default.
• W3005555877 cites W2766889539 @default.
• W3005555877 cites W2781967165 @default.
• W3005555877 cites W2791340694 @default.
• W3005555877 cites W2794075769 @default.
• W3005555877 cites W2905062224 @default.
• W3005555877 cites W2807586243 @default.
• W3005555877 doi "https://doi.org/10.1016/j.ecoenv.2020.110253" @default.
• W3005555877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32059163" @default.
• W3005555877 hasPublicationYear "2020" @default.
• W3005555877 type Work @default.
• W3005555877 sameAs 3005555877 @default.
• W3005555877 citedByCount "29" @default.
• W3005555877 countsByYear W30055558772020 @default.
• W3005555877 countsByYear W30055558772021 @default.
• W3005555877 countsByYear W30055558772022 @default.
• W3005555877 countsByYear W30055558772023 @default.
• W3005555877 crossrefType "journal-article" @default.
• W3005555877 hasAuthorship W3005555877A5001530911 @default.
• W3005555877 hasAuthorship W3005555877A5017865884 @default.
• W3005555877 hasAuthorship W3005555877A5021541475 @default.
• W3005555877 hasAuthorship W3005555877A5030492984 @default.
• W3005555877 hasAuthorship W3005555877A5038524964 @default.
• W3005555877 hasAuthorship W3005555877A5042524516 @default.
• W3005555877 hasAuthorship W3005555877A5052304130 @default.
• W3005555877 hasAuthorship W3005555877A5067582026 @default.
• W3005555877 hasAuthorship W3005555877A5074702615 @default.
• W3005555877 hasAuthorship W3005555877A5087798833 @default.
• W3005555877 hasAuthorship W3005555877A5088076863 @default.
• W3005555877 hasConcept C104317684 @default.
• W3005555877 hasConcept C127561419 @default.
• W3005555877 hasConcept C142724271 @default.
• W3005555877 hasConcept C145059251 @default.
• W3005555877 hasConcept C1491633281 @default.
• W3005555877 hasConcept C20518536 @default.
• W3005555877 hasConcept C207865475 @default.
• W3005555877 hasConcept C2777811718 @default.
• W3005555877 hasConcept C2778229498 @default.
• W3005555877 hasConcept C2780381497 @default.
• W3005555877 hasConcept C2780559512 @default.
• W3005555877 hasConcept C2780932548 @default.
• W3005555877 hasConcept C2781261824 @default.
• W3005555877 hasConcept C28328180 @default.
• W3005555877 hasConcept C502942594 @default.
• W3005555877 hasConcept C54355233 @default.
• W3005555877 hasConcept C60870556 @default.
• W3005555877 hasConcept C62478195 @default.
• W3005555877 hasConcept C71924100 @default.
• W3005555877 hasConcept C81885089 @default.
• W3005555877 hasConcept C86803240 @default.
• W3005555877 hasConcept C95444343 @default.
• W3005555877 hasConceptScore W3005555877C104317684 @default.
• W3005555877 hasConceptScore W3005555877C127561419 @default.
• W3005555877 hasConceptScore W3005555877C142724271 @default.
• W3005555877 hasConceptScore W3005555877C145059251 @default.
• W3005555877 hasConceptScore W3005555877C1491633281 @default.
• W3005555877 hasConceptScore W3005555877C20518536 @default.
• W3005555877 hasConceptScore W3005555877C207865475 @default.
• W3005555877 hasConceptScore W3005555877C2777811718 @default.

• next