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• W3005583034 abstract "Our objective was to assess the feasibility and accuracy of Cerenkov luminescence imaging (CLI) for assessment of surgical margins intraoperatively during radical prostatectomy. <b>Methods:</b> A single-center feasibility study included 10 patients with high-risk primary prostate cancer (PC). ⁶⁸Ga-prostate-specific membrane antigen (PSMA) PET/CT scans were performed followed by radical prostatectomy and intraoperative CLI of the excised prostate. In addition to imaging the intact prostate, in the first 2 patients the prostate gland was incised and imaged with CLI to visualize the primary tumor. We compared the tumor margin status on CLI to postoperative histopathology. Measured CLI intensities were determined as tumor-to-background ratio. <b>Results:</b> Tumor cells were successfully detected on the incised prostate CLI images as confirmed by histopathology. Three of 10 men had histopathologically positive surgical margins (PSMs), and 2 of 3 PSMs were accurately detected on CLI. Overall, 25 (72%) of 35 regions of interest proved to visualize a tumor signal according to standard histopathology. The median tumor radiance in these areas was 11,301 photons/s/cm²/sr (range, 3,328–25,428 photons/s/cm²/sr), and median tumor-to-background ratio was 4.2 (range, 2.1–11.6). False-positive signals were seen mainly at the prostate base, with PC cells overlaid by benign tissue. PSMA immunohistochemistry revealed strong PSMA staining of benign gland tissue, which impacts measured activities. <b>Conclusion:</b> This feasibility showed that ⁶⁸Ga-PSMA CLI is a new intraoperative imaging technique capable of imaging the entire specimen’s surface to detect PC tissue at the resection margin. Further optimization of the CLI protocol, or the use of lower-energy imaging tracers such as ¹⁸F-PSMA, is required to reduce false-positives. A larger study will be performed to assess diagnostic performance." @default.
• W3005583034 created "2020-02-24" @default.
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• W3005583034 date "2020-02-14" @default.
• W3005583034 modified "2023-10-11" @default.
• W3005583034 title "Intraoperative ⁶⁸Ga-PSMA Cerenkov Luminescence Imaging for Surgical Margins in Radical Prostatectomy: A Feasibility Study" @default.
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• W3005583034 doi "https://doi.org/10.2967/jnumed.119.240424" @default.
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