FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3005591251> ?p ?o ?g. }

• W3005591251 endingPage "120" @default.
• W3005591251 startingPage "111" @default.
• W3005591251 abstract "Abstract Background The optimal intravenous (IV) iron would allow safe correction of iron deficiency at a single infusion over a short time. The FERWON-NEPHRO trial evaluated the safety and efficacy of iron isomaltoside 1000/ferric derisomaltose (IIM) in patients with non-dialysis-dependent chronic kidney disease and iron deficiency anaemia. Methods In this randomized, open-label and multi-centre trial conducted in the USA, patients were randomized 2:1 to a single dose of 1000 mg IIM or iron sucrose (IS) administered as 200 mg IV injections up to five times within a 2-week period. The co-primary endpoints were serious or severe hypersensitivity reactions and change in haemoglobin (Hb) from baseline to Week 8. Secondary endpoints included incidence of composite cardiovascular adverse events (AEs). Results A total of 1538 patients were enrolled (mean estimated glomerular filtration rate 35.5 mL/min/1.73 m2). The co-primary safety objective was met based on no significant difference in the incidence of serious or severe hypersensitivity reactions in the IIM and IS groups [0.3% versus 0%; risk difference: 0.29% (95% confidence interval: –0.19; 0.77; P &gt; 0.05)]. Incidence of composite cardiovascular AEs was significantly lower in the IIM versus IS group (4.1% versus 6.9%; P = 0.025). Compared with IS, IIM led to a more pronounced increase in Hb during the first 4 weeks (P ≤ 0.021), and change in Hb to Week 8 showed non-inferiority, confirming that the co-primary efficacy objective was met. Conclusions Compared with multiple doses of IS, a single dose of IIM induced a non-inferior 8-week haematological response, comparably low rates of hypersensitivity reactions, and a significantly lower incidence of composite cardiovascular AEs." @default.
• W3005591251 created "2020-02-24" @default.
• W3005591251 creator A5008906136 @default.
• W3005591251 creator A5023133455 @default.
• W3005591251 creator A5050140429 @default.
• W3005591251 creator A5061754196 @default.
• W3005591251 creator A5086644818 @default.
• W3005591251 creator A5086923762 @default.
• W3005591251 date "2020-02-12" @default.
• W3005591251 modified "2023-10-15" @default.
• W3005591251 title "Safety and efficacy of iron isomaltoside 1000/ferric derisomaltose versus iron sucrose in patients with chronic kidney disease: the FERWON-NEPHRO randomized, open-label, comparative trial" @default.
• W3005591251 cites W1498732084 @default.
• W3005591251 cites W1571358690 @default.
• W3005591251 cites W1723550313 @default.
• W3005591251 cites W1909098346 @default.
• W3005591251 cites W2009233748 @default.
• W3005591251 cites W2016792551 @default.
• W3005591251 cites W2021355963 @default.
• W3005591251 cites W2028265881 @default.
• W3005591251 cites W2028875361 @default.
• W3005591251 cites W2072414981 @default.
• W3005591251 cites W2103992480 @default.
• W3005591251 cites W2148669301 @default.
• W3005591251 cites W2150702340 @default.
• W3005591251 cites W2166378958 @default.
• W3005591251 cites W2192542990 @default.
• W3005591251 cites W2276227009 @default.
• W3005591251 cites W2292259692 @default.
• W3005591251 cites W2466262792 @default.
• W3005591251 cites W2466673568 @default.
• W3005591251 cites W2498371428 @default.
• W3005591251 cites W2512898051 @default.
• W3005591251 cites W2527325622 @default.
• W3005591251 cites W2564902274 @default.
• W3005591251 cites W2569842694 @default.
• W3005591251 cites W2588548713 @default.
• W3005591251 cites W2790601563 @default.
• W3005591251 cites W2794233777 @default.
• W3005591251 cites W2801651391 @default.
• W3005591251 cites W2897116873 @default.
• W3005591251 cites W2898498137 @default.
• W3005591251 cites W2978791123 @default.
• W3005591251 cites W3022673745 @default.
• W3005591251 doi "https://doi.org/10.1093/ndt/gfaa011" @default.
• W3005591251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7771981" @default.
• W3005591251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32049331" @default.
• W3005591251 hasPublicationYear "2020" @default.
• W3005591251 type Work @default.
• W3005591251 sameAs 3005591251 @default.
• W3005591251 citedByCount "50" @default.
• W3005591251 countsByYear W30055912512020 @default.
• W3005591251 countsByYear W30055912512021 @default.
• W3005591251 countsByYear W30055912512022 @default.
• W3005591251 countsByYear W30055912512023 @default.
• W3005591251 crossrefType "journal-article" @default.
• W3005591251 hasAuthorship W3005591251A5008906136 @default.
• W3005591251 hasAuthorship W3005591251A5023133455 @default.
• W3005591251 hasAuthorship W3005591251A5050140429 @default.
• W3005591251 hasAuthorship W3005591251A5061754196 @default.
• W3005591251 hasAuthorship W3005591251A5086644818 @default.
• W3005591251 hasAuthorship W3005591251A5086923762 @default.
• W3005591251 hasBestOaLocation W30055912511 @default.
• W3005591251 hasConcept C120665830 @default.
• W3005591251 hasConcept C121332964 @default.
• W3005591251 hasConcept C126322002 @default.
• W3005591251 hasConcept C141071460 @default.
• W3005591251 hasConcept C159641895 @default.
• W3005591251 hasConcept C168563851 @default.
• W3005591251 hasConcept C197934379 @default.
• W3005591251 hasConcept C203092338 @default.
• W3005591251 hasConcept C2776974161 @default.
• W3005591251 hasConcept C2777417653 @default.
• W3005591251 hasConcept C2778248108 @default.
• W3005591251 hasConcept C2778653478 @default.
• W3005591251 hasConcept C2779978075 @default.
• W3005591251 hasConcept C3020614022 @default.
• W3005591251 hasConcept C44249647 @default.
• W3005591251 hasConcept C61511704 @default.
• W3005591251 hasConcept C71924100 @default.
• W3005591251 hasConcept C90924648 @default.
• W3005591251 hasConceptScore W3005591251C120665830 @default.
• W3005591251 hasConceptScore W3005591251C121332964 @default.
• W3005591251 hasConceptScore W3005591251C126322002 @default.
• W3005591251 hasConceptScore W3005591251C141071460 @default.
• W3005591251 hasConceptScore W3005591251C159641895 @default.
• W3005591251 hasConceptScore W3005591251C168563851 @default.
• W3005591251 hasConceptScore W3005591251C197934379 @default.
• W3005591251 hasConceptScore W3005591251C203092338 @default.
• W3005591251 hasConceptScore W3005591251C2776974161 @default.
• W3005591251 hasConceptScore W3005591251C2777417653 @default.
• W3005591251 hasConceptScore W3005591251C2778248108 @default.
• W3005591251 hasConceptScore W3005591251C2778653478 @default.
• W3005591251 hasConceptScore W3005591251C2779978075 @default.
• W3005591251 hasConceptScore W3005591251C3020614022 @default.
• W3005591251 hasConceptScore W3005591251C44249647 @default.
• W3005591251 hasConceptScore W3005591251C61511704 @default.
• W3005591251 hasConceptScore W3005591251C71924100 @default.
• W3005591251 hasConceptScore W3005591251C90924648 @default.

• next