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- W3005600800 abstract "Abstract The hydrolysis of extremely stable peptide and phosphoester bonds by metalloenzymes is of great interest in biotechnology and industry. However, due to various shortcomings only a handful of these enzymes have been used for industrial applications. Therefore, in the last two decades intensive scientific efforts have been made in rational development of small molecules to imitate the activities of natural enzymes. Despite these efforts, their currently available synthetic analogues are inferior in terms of selectivity, catalytic rate, and turnover and the designing of efficient artificial metalloenzymes remains a distant goal. This is a challenging area of research that necessitates a rigorous integration between experiments and theory. The realization of this goal requires knowledge of the catalytic activities of both enzymes and their existing analogues and an effective fusion of that knowledge. This article reviews several studies in which a plethora of computational techniques have been successfully employed to investigate the functioning of two chemically promiscuous mono‐ and binuclear metalloenzymes (insulin degrading enzyme and glycerophosphodiesterase) and two synthetic analogues. These studies will help us derive fundamental principles of peptide and phosphoester hydrolysis and pave the way to design efficient small molecule catalysts for these reactions. This article is categorized under: Structure and Mechanism > Reaction Mechanisms and Catalysis" @default.
- W3005600800 created "2020-02-24" @default.
- W3005600800 creator A5010217716 @default.
- W3005600800 creator A5021010122 @default.
- W3005600800 creator A5031493178 @default.
- W3005600800 creator A5047512134 @default.
- W3005600800 creator A5048504490 @default.
- W3005600800 creator A5087438731 @default.
- W3005600800 date "2020-02-11" @default.
- W3005600800 modified "2023-10-18" @default.
- W3005600800 title "Mechanisms of peptide and phosphoester hydrolysis catalyzed by two promiscuous metalloenzymes (insulin degrading enzyme and glycerophosphodiesterase) and their synthetic analogues" @default.
- W3005600800 cites W141711550 @default.
- W3005600800 cites W1548941984 @default.
- W3005600800 cites W1553966090 @default.
- W3005600800 cites W1559744538 @default.
- W3005600800 cites W180152368 @default.
- W3005600800 cites W1835034389 @default.
- W3005600800 cites W1844893699 @default.
- W3005600800 cites W1963854634 @default.
- W3005600800 cites W1966078827 @default.
- W3005600800 cites W1967769136 @default.
- W3005600800 cites W1968031065 @default.
- W3005600800 cites W1969046853 @default.
- W3005600800 cites W1969711350 @default.
- W3005600800 cites W1971421895 @default.
- W3005600800 cites W1972097509 @default.
- W3005600800 cites W1976210162 @default.
- W3005600800 cites W1978180292 @default.
- W3005600800 cites W1980575759 @default.
- W3005600800 cites W1980635417 @default.
- W3005600800 cites W1981021420 @default.
- W3005600800 cites W1981748997 @default.
- W3005600800 cites W1981822738 @default.
- W3005600800 cites W1982099355 @default.
- W3005600800 cites W1983592761 @default.
- W3005600800 cites W1984075743 @default.
- W3005600800 cites W1986227359 @default.
- W3005600800 cites W1986894327 @default.
- W3005600800 cites W1987715285 @default.
- W3005600800 cites W1988035495 @default.
- W3005600800 cites W1989756325 @default.
- W3005600800 cites W1992408871 @default.
- W3005600800 cites W1992531741 @default.
- W3005600800 cites W1992636402 @default.
- W3005600800 cites W1995362804 @default.
- W3005600800 cites W1995541462 @default.
- W3005600800 cites W1996657371 @default.
- W3005600800 cites W2004612743 @default.
- W3005600800 cites W2005167356 @default.
- W3005600800 cites W2005481412 @default.
- W3005600800 cites W2006755910 @default.
- W3005600800 cites W2006775197 @default.
- W3005600800 cites W2007899228 @default.
- W3005600800 cites W2009345105 @default.
- W3005600800 cites W2010013989 @default.
- W3005600800 cites W2012897317 @default.
- W3005600800 cites W2014205224 @default.
- W3005600800 cites W2014288182 @default.
- W3005600800 cites W2015056922 @default.
- W3005600800 cites W2015688756 @default.
- W3005600800 cites W2017654147 @default.
- W3005600800 cites W2020217296 @default.
- W3005600800 cites W2021624791 @default.
- W3005600800 cites W2023717139 @default.
- W3005600800 cites W2024883199 @default.
- W3005600800 cites W2027206659 @default.
- W3005600800 cites W2027332928 @default.
- W3005600800 cites W2030347038 @default.
- W3005600800 cites W2030971064 @default.
- W3005600800 cites W2032278757 @default.
- W3005600800 cites W2036237070 @default.
- W3005600800 cites W2038663652 @default.
- W3005600800 cites W2039255128 @default.
- W3005600800 cites W2040710216 @default.
- W3005600800 cites W2043373655 @default.
- W3005600800 cites W2044335899 @default.
- W3005600800 cites W2045556580 @default.
- W3005600800 cites W2046606379 @default.
- W3005600800 cites W2049028137 @default.
- W3005600800 cites W2052963947 @default.
- W3005600800 cites W2053684471 @default.
- W3005600800 cites W2055411275 @default.
- W3005600800 cites W2056665391 @default.
- W3005600800 cites W2059433503 @default.
- W3005600800 cites W2062731676 @default.
- W3005600800 cites W2063255733 @default.
- W3005600800 cites W2065447802 @default.
- W3005600800 cites W2065821343 @default.
- W3005600800 cites W2069123478 @default.
- W3005600800 cites W2069196630 @default.
- W3005600800 cites W2070011632 @default.
- W3005600800 cites W2071894609 @default.
- W3005600800 cites W2072961231 @default.
- W3005600800 cites W2074651583 @default.
- W3005600800 cites W2080048885 @default.
- W3005600800 cites W2082240350 @default.
- W3005600800 cites W2084363574 @default.
- W3005600800 cites W2085157761 @default.
- W3005600800 cites W2087230704 @default.
- W3005600800 cites W2087849062 @default.